Tags

Type your tag names separated by a space and hit enter

Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis.
Immunol Invest 2012; 41(5):484-96II

Abstract

Recently, protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism has been identified as a susceptibile gene for type 1 diabetes (T1D), but studies are inconsistence, In order to assess the association between PTPN22C1858T polymorphism and T1D based on different ethnicities, a meta-analysis was performed, including 26 studies, total of 16,240 patients and 17,997 controls. Meta-analysis was performed on T versus C, T/T+T/C versus C/C (dominant model) and T/T versus T/C+C/C (recessive model) in a fixed/random effects model. The results indicated an association between the PTPN22 C1858T polymorphism and T1D in all subjects. The overall odds ratio (OR) of T versus C using the fixed effects model was 1.948 (95% CI = 1.859∼2.041, P < 0.001). After stratification by ethnicity, analysis revealed that the PTPN22 C1858T polymorphism T allele was significantly associated with T1D in Europeans, Americans (OR = 1.946, 95% CI = 1.852~2.045, P < 0.001; OR = 1.946, 95% CI = 1.690~2.242, P < 0.001, respectively). Meta-analysis of the T/T+T/C genotype and the T/T genotypes showed the same results as that shown by the PTPN22 C1858T polymorphism T allele. This meta-analysis suggests a possible association between the PTPN22 C1858T polymorphism and T1D, especially in European and American populations.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22429252

Citation

Peng, Hui, et al. "Association of PTPN22 C1858T Polymorphism and Type 1 Diabetes: a Meta-analysis." Immunological Investigations, vol. 41, no. 5, 2012, pp. 484-96.
Peng H, Zhou M, Xu WD, et al. Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis. Immunol Invest. 2012;41(5):484-96.
Peng, H., Zhou, M., Xu, W. D., Xu, K., Zhai, Y., Li, R., ... Ye, D. Q. (2012). Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis. Immunological Investigations, 41(5), pp. 484-96. doi:10.3109/08820139.2012.664226.
Peng H, et al. Association of PTPN22 C1858T Polymorphism and Type 1 Diabetes: a Meta-analysis. Immunol Invest. 2012;41(5):484-96. PubMed PMID: 22429252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis. AU - Peng,Hui, AU - Zhou,Mo, AU - Xu,Wang-Dong, AU - Xu,Ke, AU - Zhai,Yu, AU - Li,Rui, AU - Wang,Wei, AU - Zhang,Yu-Jing, AU - Liu,Shan-Shan, AU - Pan,Hai-Feng, AU - Ye,Dong-Qing, Y1 - 2012/03/19/ PY - 2012/3/21/entrez PY - 2012/3/21/pubmed PY - 2012/10/10/medline SP - 484 EP - 96 JF - Immunological investigations JO - Immunol. Invest. VL - 41 IS - 5 N2 - Recently, protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism has been identified as a susceptibile gene for type 1 diabetes (T1D), but studies are inconsistence, In order to assess the association between PTPN22C1858T polymorphism and T1D based on different ethnicities, a meta-analysis was performed, including 26 studies, total of 16,240 patients and 17,997 controls. Meta-analysis was performed on T versus C, T/T+T/C versus C/C (dominant model) and T/T versus T/C+C/C (recessive model) in a fixed/random effects model. The results indicated an association between the PTPN22 C1858T polymorphism and T1D in all subjects. The overall odds ratio (OR) of T versus C using the fixed effects model was 1.948 (95% CI = 1.859∼2.041, P < 0.001). After stratification by ethnicity, analysis revealed that the PTPN22 C1858T polymorphism T allele was significantly associated with T1D in Europeans, Americans (OR = 1.946, 95% CI = 1.852~2.045, P < 0.001; OR = 1.946, 95% CI = 1.690~2.242, P < 0.001, respectively). Meta-analysis of the T/T+T/C genotype and the T/T genotypes showed the same results as that shown by the PTPN22 C1858T polymorphism T allele. This meta-analysis suggests a possible association between the PTPN22 C1858T polymorphism and T1D, especially in European and American populations. SN - 1532-4311 UR - https://www.unboundmedicine.com/medline/citation/22429252/Association_of_PTPN22_C1858T_polymorphism_and_type_1_diabetes:_a_meta_analysis_ L2 - http://www.tandfonline.com/doi/full/10.3109/08820139.2012.664226 DB - PRIME DP - Unbound Medicine ER -