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Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH.

Abstract

In the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (d-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated the possibilities to validate the animal model induced by methamphetamine (m-AMPH). Then, we evaluated the effects of lithium (Li), valproate (VPA) on the behavior and parameters of oxidative damage in rat brain after administration of m-AMPH. In the prevention treatment, Wistar rats were pretreated with Li, VPA or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with m-AMPH (1, 0.5 or 0.25 mg/kg) or Sal. In the reversal treatment, rats were first given m-AMPH (0.25 mg/kg) or Sal. Locomotor behavior was assessed using the open-field task and parameters of oxidative damage were measured in brain structures. Our results show that the hyperactivity was prevented and reverted by Li and VPA only when m-AMPH was administered in the dose of 0.25mg/kg. In addition, the m-AMPH in all doses administrated induced oxidative damage in both structures tested in two models. Li and VPA reversed and prevented this impairment, however in a way dependent of cerebral area, the dose of m-AMPH and technique.

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  • Authors+Show Affiliations

    ,

    Laboratory of Neurosciences and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.

    , , , , , , , ,

    Source

    Psychiatry research 198:3 2012 Aug 15 pg 521-6

    MeSH

    Animals
    Antimanic Agents
    Bipolar Disorder
    Brain
    Disease Models, Animal
    Dose-Response Relationship, Drug
    Lithium Compounds
    Male
    Methamphetamine
    Motor Activity
    Oxidative Stress
    Protein Carbonylation
    Rats
    Rats, Wistar
    Thiobarbituric Acid Reactive Substances
    Valproic Acid

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22429481

    Citation

    da-Rosa, Dayane D., et al. "Effects of Lithium and Valproate On Oxidative Stress and Behavioral Changes Induced By Administration of M-AMPH." Psychiatry Research, vol. 198, no. 3, 2012, pp. 521-6.
    da-Rosa DD, Valvassori SS, Steckert AV, et al. Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH. Psychiatry Res. 2012;198(3):521-6.
    da-Rosa, D. D., Valvassori, S. S., Steckert, A. V., Ornell, F., Ferreira, C. L., Lopes-Borges, J., ... Quevedo, J. (2012). Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH. Psychiatry Research, 198(3), pp. 521-6. doi:10.1016/j.psychres.2012.01.019.
    da-Rosa DD, et al. Effects of Lithium and Valproate On Oxidative Stress and Behavioral Changes Induced By Administration of M-AMPH. Psychiatry Res. 2012 Aug 15;198(3):521-6. PubMed PMID: 22429481.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH. AU - da-Rosa,Dayane D, AU - Valvassori,Samira S, AU - Steckert,Amanda V, AU - Ornell,Felipe, AU - Ferreira,Camila L, AU - Lopes-Borges,Jéssica, AU - Varela,Roger B, AU - Dal-Pizzol,Felipe, AU - Andersen,Monica L, AU - Quevedo,João, Y1 - 2012/03/17/ PY - 2011/10/04/received PY - 2012/01/12/revised PY - 2012/01/18/accepted PY - 2012/3/21/entrez PY - 2012/3/21/pubmed PY - 2013/5/1/medline SP - 521 EP - 6 JF - Psychiatry research JO - Psychiatry Res VL - 198 IS - 3 N2 - In the last years our research group has studied and validated the animal model of mania induced by dextroamphetamine (d-AMPH). Considering the lack of animal models of mania reported in the literature; this study evaluated the possibilities to validate the animal model induced by methamphetamine (m-AMPH). Then, we evaluated the effects of lithium (Li), valproate (VPA) on the behavior and parameters of oxidative damage in rat brain after administration of m-AMPH. In the prevention treatment, Wistar rats were pretreated with Li, VPA or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with m-AMPH (1, 0.5 or 0.25 mg/kg) or Sal. In the reversal treatment, rats were first given m-AMPH (0.25 mg/kg) or Sal. Locomotor behavior was assessed using the open-field task and parameters of oxidative damage were measured in brain structures. Our results show that the hyperactivity was prevented and reverted by Li and VPA only when m-AMPH was administered in the dose of 0.25mg/kg. In addition, the m-AMPH in all doses administrated induced oxidative damage in both structures tested in two models. Li and VPA reversed and prevented this impairment, however in a way dependent of cerebral area, the dose of m-AMPH and technique. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/22429481/Effects_of_lithium_and_valproate_on_oxidative_stress_and_behavioral_changes_induced_by_administration_of_m_AMPH_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(12)00049-2 DB - PRIME DP - Unbound Medicine ER -