Citation
Yamaguchi, Hiroaki, et al. "A Rapid and Sensitive LC/ESI-MS/MS Method for Quantitative Analysis of Docetaxel in Human Plasma and Its Application to a Pharmacokinetic Study." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 893-894, 2012, pp. 157-61.
Yamaguchi H, Fujikawa A, Ito H, et al. A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;893-894:157-61.
Yamaguchi, H., Fujikawa, A., Ito, H., Tanaka, N., Furugen, A., Miyamori, K., Takahashi, N., Ogura, J., Kobayashi, M., Yamada, T., Mano, N., & Iseki, K. (2012). A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 893-894, 157-61. https://doi.org/10.1016/j.jchromb.2012.02.003
Yamaguchi H, et al. A Rapid and Sensitive LC/ESI-MS/MS Method for Quantitative Analysis of Docetaxel in Human Plasma and Its Application to a Pharmacokinetic Study. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 15;893-894:157-61. PubMed PMID: 22429876.
TY - JOUR
T1 - A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study.
AU - Yamaguchi,Hiroaki,
AU - Fujikawa,Asuka,
AU - Ito,Hajime,
AU - Tanaka,Nobuaki,
AU - Furugen,Ayako,
AU - Miyamori,Kazuaki,
AU - Takahashi,Natsuko,
AU - Ogura,Jiro,
AU - Kobayashi,Masaki,
AU - Yamada,Takehiro,
AU - Mano,Nariyasu,
AU - Iseki,Ken,
Y1 - 2012/02/09/
PY - 2011/10/24/received
PY - 2012/01/11/revised
PY - 2012/02/03/accepted
PY - 2012/3/21/entrez
PY - 2012/3/21/pubmed
PY - 2012/7/27/medline
SP - 157
EP - 61
JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
JO - J Chromatogr B Analyt Technol Biomed Life Sci
VL - 893-894
N2 - Docetaxel is a taxane family antineoplastic agent widely employed in cancer chemotherapy. We developed a liquid chromatography/tandem mass spectrometry method for the determination of docetaxel in human plasma. Plasma samples were deproteinized by acetonitrile containing internal standard paclitaxel. Chromatographic separation was performed on a TSKgel ODS-100 V 3 μm (50 mm × 2.0 mm i.d.) column using a mobile phase composed of acetonitrile-methanol-water-formic acid (50:5:45:0.1, v/v/v/v). Detection was performed on a triple-quadrupole tandem mass spectrometer with multiple reaction monitoring (MRM) mode via electrospray ionization (ESI) source. This method covered a linearity range of 5-5000 ng/mL with the lower limit of quantification of 5 ng/mL. The intra-day precision and inter-day precision (R.S.D.) of analysis were less than 6.7%, and the accuracy (R.E.) was within ± 9.0% at the concentrations of 5, 20, 200, and 2000 ng/mL. The total run time was 5.0 min. This method was successfully applied for clinical pharmacokinetic investigation.
SN - 1873-376X
UR - https://www.unboundmedicine.com/medline/citation/22429876/A_rapid_and_sensitive_LC/ESI_MS/MS_method_for_quantitative_analysis_of_docetaxel_in_human_plasma_and_its_application_to_a_pharmacokinetic_study_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1570-0232(12)00078-5
DB - PRIME
DP - Unbound Medicine
ER -
