Tags

Type your tag names separated by a space and hit enter

Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population.
Clin Rheumatol. 2012 Jul; 31(7):1051-7.CR

Abstract

The objective of this study is to investigate the relationship between single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor-α (TNF-α) and Fas genes and Kashin-Beck disease (KBD) in Shaanxi province, Northwest in China. Blood samples of 388 residents were collected from 14 KBD villages in Linyou and Yongshou counties, Shaanxi, Northern of China. One hundred eighty-six cases with KBD and 202 cases of health in KBD areas were diagnosed by "Diagnosis Criterion of Kashin-Beck disease in China (WS/T207- 2010)". The TNF-α -308G/A, TNF-α -238G/A, and Fas -670A/G SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in combination with sequence analysis in KBD and healthy control groups. The genotypes and allele frequencies distribution of these SNPs were then analyzed. TNF-α -308A allele frequency in KBD patients were significantly higher than that in healthy controls. Although TNF-α -238 genotypes and allele frequencies were not significantly different between KBD patients and the healthy controls, GA genotype and A allele frequency in KBD patients were higher than those in healthy controls. The TNF-α -308G/A SNPs were associated with the susceptibility of KBD.

Authors+Show Affiliations

Faculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Key Laboratory of Trace Elements and Endemic Diseases, Ministry of Health, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an, Shaanxi 710061, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22431252

Citation

Zhao, Quan-ming, et al. "Association of TNF-α and Fas Gene Promoter Polymorphism With the Risk of Kashin-Beck Disease in Northwest Chinese Population." Clinical Rheumatology, vol. 31, no. 7, 2012, pp. 1051-7.
Zhao QM, Guo X, Lai JH, et al. Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population. Clin Rheumatol. 2012;31(7):1051-7.
Zhao, Q. M., Guo, X., Lai, J. H., Tan, W. H., Wang, W. Z., & Dang, X. Q. (2012). Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population. Clinical Rheumatology, 31(7), 1051-7. https://doi.org/10.1007/s10067-012-1975-7
Zhao QM, et al. Association of TNF-α and Fas Gene Promoter Polymorphism With the Risk of Kashin-Beck Disease in Northwest Chinese Population. Clin Rheumatol. 2012;31(7):1051-7. PubMed PMID: 22431252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of TNF-α and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population. AU - Zhao,Quan-ming, AU - Guo,Xiong, AU - Lai,Jiang-hua, AU - Tan,Wu-hong, AU - Wang,Wei-zhuo, AU - Dang,Xiao-qian, Y1 - 2012/03/20/ PY - 2011/12/07/received PY - 2012/03/06/accepted PY - 2012/02/20/revised PY - 2012/3/21/entrez PY - 2012/3/21/pubmed PY - 2012/12/10/medline SP - 1051 EP - 7 JF - Clinical rheumatology JO - Clin Rheumatol VL - 31 IS - 7 N2 - The objective of this study is to investigate the relationship between single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor-α (TNF-α) and Fas genes and Kashin-Beck disease (KBD) in Shaanxi province, Northwest in China. Blood samples of 388 residents were collected from 14 KBD villages in Linyou and Yongshou counties, Shaanxi, Northern of China. One hundred eighty-six cases with KBD and 202 cases of health in KBD areas were diagnosed by "Diagnosis Criterion of Kashin-Beck disease in China (WS/T207- 2010)". The TNF-α -308G/A, TNF-α -238G/A, and Fas -670A/G SNPs were determined by polymerase chain reaction-restriction fragment length polymorphism in combination with sequence analysis in KBD and healthy control groups. The genotypes and allele frequencies distribution of these SNPs were then analyzed. TNF-α -308A allele frequency in KBD patients were significantly higher than that in healthy controls. Although TNF-α -238 genotypes and allele frequencies were not significantly different between KBD patients and the healthy controls, GA genotype and A allele frequency in KBD patients were higher than those in healthy controls. The TNF-α -308G/A SNPs were associated with the susceptibility of KBD. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/22431252/Association_of_TNF_α_and_Fas_gene_promoter_polymorphism_with_the_risk_of_Kashin_Beck_disease_in_Northwest_Chinese_population_ L2 - https://dx.doi.org/10.1007/s10067-012-1975-7 DB - PRIME DP - Unbound Medicine ER -