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An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics.
J Diet Suppl. 2010 Sep; 7(3):273-82.JD

Abstract

Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia, and associated with long-term damage and dysfunction of various organs. Management of diabetes is therefore vital and involves maintaining euglycemia as much as possible by reducing blood glucose and by increasing insulin sensitivity and peripheral glucose uptake. Ayurveda has promoted the management of diabetes by regulating carbohydrate metabolism using several medicinal herbs, one of which is Gymnema sylvestre (GS). GS has been used in parts of India as a hypoglycemic agent and the results have been encouraging. Accordingly, we planned a quasi-experimental study to investigate the efficacy of the herb among type 2 diabetics. Patients enrolled from free-living population were purposively assigned to experimental or control groups, based on their willingness to participate in the study. The experimental group was supplemented with 500 mg of the herb per day for a period of 3 months, and the efficacy of the herb was assessed through a battery of clinical and biochemical tests. Supplementation of the diet with GS reduced polyphagia, fatigue, blood glucose (fasting and post-prandial), and glycated hemoglobin and there was a favorable shift in lipid profiles and in other clinico-biochemical tests. These findings suggest a beneficial effect of GS in the management of diabetes mellitus.

Authors+Show Affiliations

Department of Foods and Nutrition, WHO Collaborating Centre for Research & Training in Promoting Nutrition in Health & Development, The M S University of Baroda, Vadodara, Gujarat 390 020, India. smitz 22@yahoo.co.inNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22432517

Citation

Kumar, Smriti Nanda, et al. "An Open Label Study On the Supplementation of Gymnema Sylvestre in Type 2 Diabetics." Journal of Dietary Supplements, vol. 7, no. 3, 2010, pp. 273-82.
Kumar SN, Mani UV, Mani I. An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. J Diet Suppl. 2010;7(3):273-82.
Kumar, S. N., Mani, U. V., & Mani, I. (2010). An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. Journal of Dietary Supplements, 7(3), 273-82. https://doi.org/10.3109/19390211.2010.505901
Kumar SN, Mani UV, Mani I. An Open Label Study On the Supplementation of Gymnema Sylvestre in Type 2 Diabetics. J Diet Suppl. 2010;7(3):273-82. PubMed PMID: 22432517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. AU - Kumar,Smriti Nanda, AU - Mani,Uliyar Vitaldas, AU - Mani,Indirani, PY - 2012/3/22/entrez PY - 2010/9/1/pubmed PY - 2012/7/28/medline SP - 273 EP - 82 JF - Journal of dietary supplements JO - J Diet Suppl VL - 7 IS - 3 N2 - Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia, and associated with long-term damage and dysfunction of various organs. Management of diabetes is therefore vital and involves maintaining euglycemia as much as possible by reducing blood glucose and by increasing insulin sensitivity and peripheral glucose uptake. Ayurveda has promoted the management of diabetes by regulating carbohydrate metabolism using several medicinal herbs, one of which is Gymnema sylvestre (GS). GS has been used in parts of India as a hypoglycemic agent and the results have been encouraging. Accordingly, we planned a quasi-experimental study to investigate the efficacy of the herb among type 2 diabetics. Patients enrolled from free-living population were purposively assigned to experimental or control groups, based on their willingness to participate in the study. The experimental group was supplemented with 500 mg of the herb per day for a period of 3 months, and the efficacy of the herb was assessed through a battery of clinical and biochemical tests. Supplementation of the diet with GS reduced polyphagia, fatigue, blood glucose (fasting and post-prandial), and glycated hemoglobin and there was a favorable shift in lipid profiles and in other clinico-biochemical tests. These findings suggest a beneficial effect of GS in the management of diabetes mellitus. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/22432517/An_open_label_study_on_the_supplementation_of_Gymnema_sylvestre_in_type_2_diabetics_ L2 - https://www.tandfonline.com/doi/full/10.3109/19390211.2010.505901 DB - PRIME DP - Unbound Medicine ER -