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An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus.
J Diet Suppl. 2011 Sep; 8(3):257-65.JD

Abstract

Diabetes mellitus is characterized by hyperglycemia and associated with aberrations in the metabolism of carbohydrate, protein, and lipid that result in development of secondary complications. Extensive studies have indicated that nutritional therapy plays a pivotal role in the controlling or postponing of development of these secondary complications. Several functional foods have been shown to possess hypoglycemic and hypolipidemic properties. Flax seed (FS) is a functional food that is rich in omega 3 fatty acids and antioxidants and is low in carbohydrates. In exploratory studies, FS was incorporated in recipes, which resulted in a reduction in the glycemic index of the food items. These observations prompted us to investigate the efficacy of FS supplementation in type 2 diabetics (n = 29). Subjects were assigned to the experimental (n = 18) or the control group (n = 11) on the basis of their desire to participate in the study. The experimental group's diet was supplemented daily with 10 g of FS powder for a period of 1 month. The control group received no supplementation or placebo. During the study, diet and drug intake of the subjects remained unaltered. The efficacy of supplementation with FS was evaluated through a battery of clinico-biochemical parameters. Supplementation with FS reduced fasting blood glucose by 19.7% and glycated hemoglobin by 15.6%. A favorable reduction in total cholesterol (14.3%), triglycerides (17.5%), low-density lipoprotein cholesterol (21.8%), and apolipoprotein B and an increase in high-density lipoprotein cholesterol (11.9%) were also noticed. These observations suggest the therapeutic potential of FS in the management of diabetes mellitus.

Authors+Show Affiliations

Department of Foods and Nutrition, Faculty of Family and Community Sciences, WHO Collaborating Centre for Research & Training in Promoting Nutrition in Health & Development, MS University of Baroda, Fatehgunj, Vadodara, Gujarat, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

22432725

Citation

Mani, Uliyar Vitaldas, et al. "An Open-label Study On the Effect of Flax Seed Powder (Linum Usitatissimum) Supplementation in the Management of Diabetes Mellitus." Journal of Dietary Supplements, vol. 8, no. 3, 2011, pp. 257-65.
Mani UV, Mani I, Biswas M, et al. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl. 2011;8(3):257-65.
Mani, U. V., Mani, I., Biswas, M., & Kumar, S. N. (2011). An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. Journal of Dietary Supplements, 8(3), 257-65. https://doi.org/10.3109/19390211.2011.593615
Mani UV, et al. An Open-label Study On the Effect of Flax Seed Powder (Linum Usitatissimum) Supplementation in the Management of Diabetes Mellitus. J Diet Suppl. 2011;8(3):257-65. PubMed PMID: 22432725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. AU - Mani,Uliyar Vitaldas, AU - Mani,Indirani, AU - Biswas,Mamta, AU - Kumar,Smriti Nanda, Y1 - 2011/07/15/ PY - 2012/3/22/entrez PY - 2012/3/22/pubmed PY - 2012/7/28/medline SP - 257 EP - 65 JF - Journal of dietary supplements JO - J Diet Suppl VL - 8 IS - 3 N2 - Diabetes mellitus is characterized by hyperglycemia and associated with aberrations in the metabolism of carbohydrate, protein, and lipid that result in development of secondary complications. Extensive studies have indicated that nutritional therapy plays a pivotal role in the controlling or postponing of development of these secondary complications. Several functional foods have been shown to possess hypoglycemic and hypolipidemic properties. Flax seed (FS) is a functional food that is rich in omega 3 fatty acids and antioxidants and is low in carbohydrates. In exploratory studies, FS was incorporated in recipes, which resulted in a reduction in the glycemic index of the food items. These observations prompted us to investigate the efficacy of FS supplementation in type 2 diabetics (n = 29). Subjects were assigned to the experimental (n = 18) or the control group (n = 11) on the basis of their desire to participate in the study. The experimental group's diet was supplemented daily with 10 g of FS powder for a period of 1 month. The control group received no supplementation or placebo. During the study, diet and drug intake of the subjects remained unaltered. The efficacy of supplementation with FS was evaluated through a battery of clinico-biochemical parameters. Supplementation with FS reduced fasting blood glucose by 19.7% and glycated hemoglobin by 15.6%. A favorable reduction in total cholesterol (14.3%), triglycerides (17.5%), low-density lipoprotein cholesterol (21.8%), and apolipoprotein B and an increase in high-density lipoprotein cholesterol (11.9%) were also noticed. These observations suggest the therapeutic potential of FS in the management of diabetes mellitus. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/22432725/An_open_label_study_on_the_effect_of_flax_seed_powder__Linum_usitatissimum__supplementation_in_the_management_of_diabetes_mellitus_ L2 - https://www.tandfonline.com/doi/full/10.3109/19390211.2011.593615 DB - PRIME DP - Unbound Medicine ER -