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Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum.
BMC Res Notes. 2012 Mar 20; 5:158.BR

Abstract

BACKGROUND

Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum.

RESULTS

The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC) values ranging from 32 to 512 μg/ml and antioxidant property with an IC50 value of 52.48 μg/ml. Its partition enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC = 256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC50 values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides, including; kaempferitrin (1), kaempferol 3-O-α-L-(2-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-(3-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-(4-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (4), kaempferol 3-O-α-D- glucopyranoside-7-O-α-L-rhamnopyranoside (5), afzelin (6) and α-rhamnoisorobin (7). All these compounds, except 6 were isolated from this plant for the first time. Compound 7 was the most active, with MIC values ranging from 1 to 2 μg/ml and its antioxidant activity (IC50 = 0.71 μg/ml) was higher than that of the reference drug (IC50 = 0.96 μg/ml).

CONCLUSION

These findings demonstrate that Bryophyllum pinnatum and some of its isolated compounds have interesting antimicrobial and antioxidant properties, and therefore confirming the traditional use of B. pinnatum in the treatment of infectious and free radical damages.

Authors+Show Affiliations

Department of Chemistry, Higher Teachers' Training College, University of Maroua, P,O, Box 55, Maroua, Cameroon. jtatsimo@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22433844

Citation

Tatsimo, Simplice Joel Ndendoung, et al. "Antimicrobial and Antioxidant Activity of Kaempferol Rhamnoside Derivatives From Bryophyllum Pinnatum." BMC Research Notes, vol. 5, 2012, p. 158.
Tatsimo SJ, Tamokou Jde D, Havyarimana L, et al. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Res Notes. 2012;5:158.
Tatsimo, S. J., Tamokou, J. d. e. . D., Havyarimana, L., Csupor, D., Forgo, P., Hohmann, J., Kuiate, J. R., & Tane, P. (2012). Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Research Notes, 5, 158. https://doi.org/10.1186/1756-0500-5-158
Tatsimo SJ, et al. Antimicrobial and Antioxidant Activity of Kaempferol Rhamnoside Derivatives From Bryophyllum Pinnatum. BMC Res Notes. 2012 Mar 20;5:158. PubMed PMID: 22433844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. AU - Tatsimo,Simplice Joel Ndendoung, AU - Tamokou,Jean de Dieu, AU - Havyarimana,Léopold, AU - Csupor,Dezső, AU - Forgo,Peter, AU - Hohmann,Judit, AU - Kuiate,Jules-Roger, AU - Tane,Pierre, Y1 - 2012/03/20/ PY - 2011/12/01/received PY - 2012/03/20/accepted PY - 2012/3/22/entrez PY - 2012/3/22/pubmed PY - 2013/2/28/medline SP - 158 EP - 158 JF - BMC research notes JO - BMC Res Notes VL - 5 N2 - BACKGROUND: Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses in folk medicine justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation of antimicrobial and/or antioxidant components from the EtOAc extract of B. pinnatum. RESULTS: The methanol extract displayed both antimicrobial activities with minimum inhibitory concentration (MIC) values ranging from 32 to 512 μg/ml and antioxidant property with an IC50 value of 52.48 μg/ml. Its partition enhanced the antimicrobial activity in EtOAc extract (MIC = 16-128 μg/ml) and reduced it in hexane extract (MIC = 256-1024 μg/ml). In addition, this process reduced the antioxidant activity in EtOAc and hexane extracts with IC50 values of 78.11 and 90.04 μg/ml respectively. Fractionation of EtOAc extract gave seven kaempferol rhamnosides, including; kaempferitrin (1), kaempferol 3-O-α-L-(2-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-(3-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-(4-acetyl)rhamnopyranoside-7-O-α-L-rhamnopyranoside (4), kaempferol 3-O-α-D- glucopyranoside-7-O-α-L-rhamnopyranoside (5), afzelin (6) and α-rhamnoisorobin (7). All these compounds, except 6 were isolated from this plant for the first time. Compound 7 was the most active, with MIC values ranging from 1 to 2 μg/ml and its antioxidant activity (IC50 = 0.71 μg/ml) was higher than that of the reference drug (IC50 = 0.96 μg/ml). CONCLUSION: These findings demonstrate that Bryophyllum pinnatum and some of its isolated compounds have interesting antimicrobial and antioxidant properties, and therefore confirming the traditional use of B. pinnatum in the treatment of infectious and free radical damages. SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/22433844/Antimicrobial_and_antioxidant_activity_of_kaempferol_rhamnoside_derivatives_from_Bryophyllum_pinnatum_ L2 - https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-158 DB - PRIME DP - Unbound Medicine ER -