Type your tag names separated by a space and hit enter

Postprandial platelet aggregation: effects of different meals and glycemic index.

Abstract

BACKGROUND/OBJECTIVES

Hyperglycaemia is associated with increased platelet aggregation that increases the risk of thrombosis in people with type-2 diabetes and cardiovascular disease. Low glycemic index (GI) meals high in carbohydrate or moderately high in protein have been shown to acutely reduce postprandial excursions of plasma glucose and insulin compared with high carbohydrate high GI meals. However, it is not known whether these differences in glucose and insulin profile also impact on postprandial platelet aggregation. This study aimed to investigate the acute effects of three iso-energetic meals, on measures of postprandial platelet aggregation, in healthy individuals.

SUBJECTS/METHODS

A randomised cross-over study compared the acute effects of a high GI high carbohydrate (HGI-HC), a low GI high carbohydrate (LGI-HC) and a low GI moderately high in protein and fat (LGI-MPF) meal on postprandial platelet aggregation, glucose, insulin and triglyceride concentrations. Comparisons were made at fasting, 60 and 120 min postprandially.

RESULTS

A total of 32 volunteers (mean ± s.d.; age 59.9 ± 11.7 years, BMI 27.1 ± 3.7 kg/m(2)) participated in the study. Results showed significant reductions in maximum platelet aggregation postprandially with nonsignificant differences (all P > 0.29) between the three meals. Glucose and insulin were significantly (both P < 0.001) higher at 60 min postprandially on the HGI-HC meal compared with both LGI-HC and LGI-MPF meals. Triglycerides were not significantly different (all P > 0.25) between the three test meals.

CONCLUSION

In healthy individuals platelet aggregation is reduced postprandially but this decrease is similar between meals of different GI that induce different glucose and insulin responses.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia.

    , ,

    Source

    MeSH

    Aged
    Blood Glucose
    Cardiovascular Diseases
    Cross-Over Studies
    Diabetes Complications
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Dietary Proteins
    Energy Intake
    Female
    Glycemic Index
    Humans
    Hyperglycemia
    Insulin
    Male
    Middle Aged
    Platelet Aggregation
    Postprandial Period
    Reference Values
    Thrombosis
    Triglycerides

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22434051

    Citation

    Ahuja, K D K., et al. "Postprandial Platelet Aggregation: Effects of Different Meals and Glycemic Index." European Journal of Clinical Nutrition, vol. 66, no. 6, 2012, pp. 722-6.
    Ahuja KD, Thomas GA, Adams MJ, et al. Postprandial platelet aggregation: effects of different meals and glycemic index. Eur J Clin Nutr. 2012;66(6):722-6.
    Ahuja, K. D., Thomas, G. A., Adams, M. J., & Ball, M. J. (2012). Postprandial platelet aggregation: effects of different meals and glycemic index. European Journal of Clinical Nutrition, 66(6), pp. 722-6. doi:10.1038/ejcn.2012.28.
    Ahuja KD, et al. Postprandial Platelet Aggregation: Effects of Different Meals and Glycemic Index. Eur J Clin Nutr. 2012;66(6):722-6. PubMed PMID: 22434051.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Postprandial platelet aggregation: effects of different meals and glycemic index. AU - Ahuja,K D K, AU - Thomas,G A, AU - Adams,M J, AU - Ball,M J, Y1 - 2012/03/21/ PY - 2012/3/22/entrez PY - 2012/3/22/pubmed PY - 2012/10/2/medline SP - 722 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 6 N2 - BACKGROUND/OBJECTIVES: Hyperglycaemia is associated with increased platelet aggregation that increases the risk of thrombosis in people with type-2 diabetes and cardiovascular disease. Low glycemic index (GI) meals high in carbohydrate or moderately high in protein have been shown to acutely reduce postprandial excursions of plasma glucose and insulin compared with high carbohydrate high GI meals. However, it is not known whether these differences in glucose and insulin profile also impact on postprandial platelet aggregation. This study aimed to investigate the acute effects of three iso-energetic meals, on measures of postprandial platelet aggregation, in healthy individuals. SUBJECTS/METHODS: A randomised cross-over study compared the acute effects of a high GI high carbohydrate (HGI-HC), a low GI high carbohydrate (LGI-HC) and a low GI moderately high in protein and fat (LGI-MPF) meal on postprandial platelet aggregation, glucose, insulin and triglyceride concentrations. Comparisons were made at fasting, 60 and 120 min postprandially. RESULTS: A total of 32 volunteers (mean ± s.d.; age 59.9 ± 11.7 years, BMI 27.1 ± 3.7 kg/m(2)) participated in the study. Results showed significant reductions in maximum platelet aggregation postprandially with nonsignificant differences (all P > 0.29) between the three meals. Glucose and insulin were significantly (both P < 0.001) higher at 60 min postprandially on the HGI-HC meal compared with both LGI-HC and LGI-MPF meals. Triglycerides were not significantly different (all P > 0.25) between the three test meals. CONCLUSION: In healthy individuals platelet aggregation is reduced postprandially but this decrease is similar between meals of different GI that induce different glucose and insulin responses. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22434051/Postprandial_platelet_aggregation:_effects_of_different_meals_and_glycemic_index_ L2 - http://dx.doi.org/10.1038/ejcn.2012.28 DB - PRIME DP - Unbound Medicine ER -