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Myogenic waves and myogenic programs during Xenopus embryonic myogenesis.
Dev Dyn. 2012 May; 241(5):995-1007.DD

Abstract

Although Xenopus is a key model organism in developmental biology, little is known about the myotome formation in this species. Here, we assessed the expression of myogenic regulatory factors of the Myod family (MRFs) during embryonic development and revealed distinct MRF programs.

RESULTS

The expression pattern of each MRF during embryonic development highlights three successive myogenic waves. We showed that a first median and lateral myogenesis initiates before dermomyotome formation: the median cell population expresses Myf5, Myod, and Mrf4, whereas the lateral one expresses Myod, moderate levels of Myogenin and Mrf4. The second wave of myoblasts arising from the dermomyotome is characterized by the full MRF program expression, with high levels of Myogenin. The third wave is revealed by Myf5 expression in the myotome and could contribute to the formation of plurinucleated fibers at larval stages. Furthermore, Myf5- or Myod-expressing anlagen are identified in craniofacial myogenesis.

CONCLUSIONS

The first median and lateral myogenesis and their associated MRF programs have probably disappeared in mammals. However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5-dependent and -independent lineages.

Authors+Show Affiliations

Centre d'Etude de la Sensori-Motricité, UMR 8194 CNRS, Université Paris Descartes, Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22434732

Citation

Della Gaspera, Bruno, et al. "Myogenic Waves and Myogenic Programs During Xenopus Embryonic Myogenesis." Developmental Dynamics : an Official Publication of the American Association of Anatomists, vol. 241, no. 5, 2012, pp. 995-1007.
Della Gaspera B, Armand AS, Sequeira I, et al. Myogenic waves and myogenic programs during Xenopus embryonic myogenesis. Dev Dyn. 2012;241(5):995-1007.
Della Gaspera, B., Armand, A. S., Sequeira, I., Chesneau, A., Mazabraud, A., Lécolle, S., Charbonnier, F., & Chanoine, C. (2012). Myogenic waves and myogenic programs during Xenopus embryonic myogenesis. Developmental Dynamics : an Official Publication of the American Association of Anatomists, 241(5), 995-1007. https://doi.org/10.1002/dvdy.23780
Della Gaspera B, et al. Myogenic Waves and Myogenic Programs During Xenopus Embryonic Myogenesis. Dev Dyn. 2012;241(5):995-1007. PubMed PMID: 22434732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myogenic waves and myogenic programs during Xenopus embryonic myogenesis. AU - Della Gaspera,Bruno, AU - Armand,Anne-Sophie, AU - Sequeira,Inés, AU - Chesneau,Albert, AU - Mazabraud,André, AU - Lécolle,Sylvie, AU - Charbonnier,Frédéric, AU - Chanoine,Christophe, PY - 2012/3/22/entrez PY - 2012/3/22/pubmed PY - 2012/9/21/medline SP - 995 EP - 1007 JF - Developmental dynamics : an official publication of the American Association of Anatomists JO - Dev Dyn VL - 241 IS - 5 N2 - UNLABELLED: Although Xenopus is a key model organism in developmental biology, little is known about the myotome formation in this species. Here, we assessed the expression of myogenic regulatory factors of the Myod family (MRFs) during embryonic development and revealed distinct MRF programs. RESULTS: The expression pattern of each MRF during embryonic development highlights three successive myogenic waves. We showed that a first median and lateral myogenesis initiates before dermomyotome formation: the median cell population expresses Myf5, Myod, and Mrf4, whereas the lateral one expresses Myod, moderate levels of Myogenin and Mrf4. The second wave of myoblasts arising from the dermomyotome is characterized by the full MRF program expression, with high levels of Myogenin. The third wave is revealed by Myf5 expression in the myotome and could contribute to the formation of plurinucleated fibers at larval stages. Furthermore, Myf5- or Myod-expressing anlagen are identified in craniofacial myogenesis. CONCLUSIONS: The first median and lateral myogenesis and their associated MRF programs have probably disappeared in mammals. However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5-dependent and -independent lineages. SN - 1097-0177 UR - https://www.unboundmedicine.com/medline/citation/22434732/Myogenic_waves_and_myogenic_programs_during_Xenopus_embryonic_myogenesis_ L2 - https://doi.org/10.1002/dvdy.23780 DB - PRIME DP - Unbound Medicine ER -