Tags

Type your tag names separated by a space and hit enter

Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats.
J Diet Suppl. 2009; 6(3):227-51.JD

Abstract

The ethanol extract of Stereospermum suaveolens (EESS) bark was evaluated for its antihyperglycemic in addition to antioxidant effects in streptozotocin (STZ)-induced diabetic rats by acute and subacute models at dose levels of 200 and 400 mg/kg body weight, given orally. The ethanol extract showed a significant reduction in fasting blood glucose levels when compared to the standard drug, oral Glibenclamide (0.5 mg/kg body weight). The serum of rats treated with ethanol extract showed decreased levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, creatinine, urea, total cholesterol, triglycerides, and increased level of total proteins. EESS showed reduction in thiobarbituric acid reactive substances level and significantly increased the body weight (P < .001), glycogen, reduced glutathione, superoxide dismutase, and catalase activities, compared with STZ diabetic control in a dose-dependent manner. This finding shows that the ethanol extract of Stereospermum suaveolens exhibits potent antihyperglycemic and antioxidant properties.

Authors+Show Affiliations

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22435475

Citation

Balasubramanian, T, et al. "Antihyperglycemic and Antioxidant Activities of Medicinal Plant Stereospermum Suaveolens in Streptozotocin-induced Diabetic Rats." Journal of Dietary Supplements, vol. 6, no. 3, 2009, pp. 227-51.
Balasubramanian T, Lal MS, Sarkar M, et al. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. J Diet Suppl. 2009;6(3):227-51.
Balasubramanian, T., Lal, M. S., Sarkar, M., & Chatterjee, T. K. (2009). Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. Journal of Dietary Supplements, 6(3), 227-51. https://doi.org/10.1080/19390210903070780
Balasubramanian T, et al. Antihyperglycemic and Antioxidant Activities of Medicinal Plant Stereospermum Suaveolens in Streptozotocin-induced Diabetic Rats. J Diet Suppl. 2009;6(3):227-51. PubMed PMID: 22435475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic and antioxidant activities of medicinal plant Stereospermum suaveolens in streptozotocin-induced diabetic rats. AU - Balasubramanian,T, AU - Lal,Meena Sunder, AU - Sarkar,Mahananda, AU - Chatterjee,Tapan Kumar, PY - 2012/3/23/entrez PY - 2009/1/1/pubmed PY - 2013/9/13/medline SP - 227 EP - 51 JF - Journal of dietary supplements JO - J Diet Suppl VL - 6 IS - 3 N2 - The ethanol extract of Stereospermum suaveolens (EESS) bark was evaluated for its antihyperglycemic in addition to antioxidant effects in streptozotocin (STZ)-induced diabetic rats by acute and subacute models at dose levels of 200 and 400 mg/kg body weight, given orally. The ethanol extract showed a significant reduction in fasting blood glucose levels when compared to the standard drug, oral Glibenclamide (0.5 mg/kg body weight). The serum of rats treated with ethanol extract showed decreased levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, creatinine, urea, total cholesterol, triglycerides, and increased level of total proteins. EESS showed reduction in thiobarbituric acid reactive substances level and significantly increased the body weight (P < .001), glycogen, reduced glutathione, superoxide dismutase, and catalase activities, compared with STZ diabetic control in a dose-dependent manner. This finding shows that the ethanol extract of Stereospermum suaveolens exhibits potent antihyperglycemic and antioxidant properties. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/22435475/Antihyperglycemic_and_antioxidant_activities_of_medicinal_plant_Stereospermum_suaveolens_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/19390210903070780 DB - PRIME DP - Unbound Medicine ER -