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A normative study of the components of niprisan--an herbal medicine for sickle cell anemia.

Abstract

Niprisan® is an herbal medicine for sickle cell anemia developed in the National Institute for Pharmaceutical Research and Development (NIPRD). It is prepared from pepper seeds [Piper guineense Schum. & Thonn., Piperaceae], clove flower buds [Eugenia caryophyllata Thunb., Myrtaceae], caprium stem [Pterocarpus osun (L.) Craib., Fabaceae], sorghum leaves [Sorghum bicolor (L.) Moench. Poaceae], and "trona" The components were sourced from food dealers and herbalists prequalified as suppliers by the Institute's department of Medicinal Plant Research and Traditional Medicine (MPRTM), based on the criteria proposed by World Health Organization (WHO, 1998. Quality control methods for medicinal plant materials, pp. 1-115. Geneva: WHO) for the collection and handling of medicinal plant materials. The aim of the work is to establish limits for features that will influence decisions on the components. The paper describes and quantifies as per WHO guidelines of 1998 and British Pharmacopoeia (British Pharmacopoeia, 2004 . Volume IV. The Stationery Office Limited, London. Appendix II D, Atomic spectrophotometry: emission and absorption, pp. A143-145. Determination of pH, pp. A143-145; Appendix VL, Determination of pH Values, pp. A199-A200, 2004.), the most striking features of these components and demonstrates that all, except Eugenia caryophyllata, exist in more than one variety. The results, including the occasional presence of lead in trona, are discussed in the context of good manufacturing practice (GMP).

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  • Authors+Show Affiliations

    ,

    Department of Medicinal Chemistry and Quality Control (MCQC), National Institute for Pharmaceutical Research and Development (NIPRD), Abuja, Federal Capital Territory, Nigeria.

    , , , , , ,

    Source

    Journal of dietary supplements 7:1 2010 Mar pg 21-30

    MeSH

    Anemia, Sickle Cell
    Bicarbonates
    Herbal Medicine
    Humans
    Hydrogen-Ion Concentration
    Phytotherapy
    Piper
    Plant Extracts
    Plants, Medicinal
    Pterocarpus
    Quality Control
    Reference Values
    Sorghum
    Species Specificity
    Spectrophotometry, Atomic
    Syzygium

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22435571

    Citation

    Obodozie, Obiageli O., et al. "A Normative Study of the Components of Niprisan--an Herbal Medicine for Sickle Cell Anemia." Journal of Dietary Supplements, vol. 7, no. 1, 2010, pp. 21-30.
    Obodozie OO, Ameh SJ, Afolabi EK, et al. A normative study of the components of niprisan--an herbal medicine for sickle cell anemia. J Diet Suppl. 2010;7(1):21-30.
    Obodozie, O. O., Ameh, S. J., Afolabi, E. K., Oyedele, E. O., Ache, T. A., Onanuga, C. E., ... Inyang, U. S. (2010). A normative study of the components of niprisan--an herbal medicine for sickle cell anemia. Journal of Dietary Supplements, 7(1), pp. 21-30. doi:10.3109/19390210903534988.
    Obodozie OO, et al. A Normative Study of the Components of Niprisan--an Herbal Medicine for Sickle Cell Anemia. J Diet Suppl. 2010;7(1):21-30. PubMed PMID: 22435571.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A normative study of the components of niprisan--an herbal medicine for sickle cell anemia. AU - Obodozie,Obiageli O, AU - Ameh,Sunday J, AU - Afolabi,Ernest K, AU - Oyedele,Eunice O, AU - Ache,Theophilus A, AU - Onanuga,Cordelia E, AU - Ibe,Martha C, AU - Inyang,Uford S, PY - 2012/3/23/entrez PY - 2010/3/1/pubmed PY - 2013/9/13/medline SP - 21 EP - 30 JF - Journal of dietary supplements JO - J Diet Suppl VL - 7 IS - 1 N2 - Niprisan® is an herbal medicine for sickle cell anemia developed in the National Institute for Pharmaceutical Research and Development (NIPRD). It is prepared from pepper seeds [Piper guineense Schum. & Thonn., Piperaceae], clove flower buds [Eugenia caryophyllata Thunb., Myrtaceae], caprium stem [Pterocarpus osun (L.) Craib., Fabaceae], sorghum leaves [Sorghum bicolor (L.) Moench. Poaceae], and "trona" The components were sourced from food dealers and herbalists prequalified as suppliers by the Institute's department of Medicinal Plant Research and Traditional Medicine (MPRTM), based on the criteria proposed by World Health Organization (WHO, 1998. Quality control methods for medicinal plant materials, pp. 1-115. Geneva: WHO) for the collection and handling of medicinal plant materials. The aim of the work is to establish limits for features that will influence decisions on the components. The paper describes and quantifies as per WHO guidelines of 1998 and British Pharmacopoeia (British Pharmacopoeia, 2004 . Volume IV. The Stationery Office Limited, London. Appendix II D, Atomic spectrophotometry: emission and absorption, pp. A143-145. Determination of pH, pp. A143-145; Appendix VL, Determination of pH Values, pp. A199-A200, 2004.), the most striking features of these components and demonstrates that all, except Eugenia caryophyllata, exist in more than one variety. The results, including the occasional presence of lead in trona, are discussed in the context of good manufacturing practice (GMP). SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/22435571/A_normative_study_of_the_components_of_niprisan__an_herbal_medicine_for_sickle_cell_anemia_ L2 - http://www.tandfonline.com/doi/full/10.3109/19390210903534988 DB - PRIME DP - Unbound Medicine ER -