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Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes.
Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1472-82.AJ

Abstract

Age-related physiological changes develop at the same time as the increase in metabolic syndrome in humans after young adulthood. There is a paucity of data in models mimicking chronic diet-induced changes in human middle age and interventions to reverse these changes. This study measured the changes during chronic consumption of a high-carbohydrate (as cornstarch), low-fat (C) diet and a high-carbohydrate (as fructose and sucrose), high-fat (H) diet in rats for 32 wk. C diet feeding induced changes without metabolic syndrome, such as disproportionate increases in total body lean and fat mass, reduced bone mineral content, cardiovascular remodeling with increased systolic blood pressure, left ventricular and arterial stiffness, and increased plasma markers of liver injury. H diet feeding induced visceral adiposity with reduced lean mass, increased lipid infiltration in the skeletal muscle, impaired glucose and insulin tolerance, cardiovascular remodeling, hepatic steatosis, and increased infiltration of inflammatory cells in the heart and the liver. Chia seed supplementation for 24 wk attenuated most structural and functional modifications induced by age or H diet, including increased whole body lean mass and lipid redistribution from the abdominal area, and normalized the chronic low-grade inflammation induced by H diet feeding; these effects may be mediated by increased metabolism of anti-inflammatory n-3 fatty acids from chia seed. These results suggest that chronic H diet feeding for 32 wk mimics the diet-induced cardiovascular and metabolic changes in middle age and that chia seed may serve as an alternative dietary strategy in the management of these changes.

Authors+Show Affiliations

School of Biomedical Sciences, The University of Queensland, Brisbane, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22436699

Citation

Poudyal, Hemant, et al. "Chronic High-carbohydrate, High-fat Feeding in Rats Induces Reversible Metabolic, Cardiovascular, and Liver Changes." American Journal of Physiology. Endocrinology and Metabolism, vol. 302, no. 12, 2012, pp. E1472-82.
Poudyal H, Panchal SK, Ward LC, et al. Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes. Am J Physiol Endocrinol Metab. 2012;302(12):E1472-82.
Poudyal, H., Panchal, S. K., Ward, L. C., Waanders, J., & Brown, L. (2012). Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes. American Journal of Physiology. Endocrinology and Metabolism, 302(12), E1472-82. https://doi.org/10.1152/ajpendo.00102.2012
Poudyal H, et al. Chronic High-carbohydrate, High-fat Feeding in Rats Induces Reversible Metabolic, Cardiovascular, and Liver Changes. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1472-82. PubMed PMID: 22436699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes. AU - Poudyal,Hemant, AU - Panchal,Sunil K, AU - Ward,Leigh C, AU - Waanders,Jennifer, AU - Brown,Lindsay, Y1 - 2012/03/20/ PY - 2012/3/23/entrez PY - 2012/3/23/pubmed PY - 2012/8/28/medline SP - E1472 EP - 82 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 302 IS - 12 N2 - Age-related physiological changes develop at the same time as the increase in metabolic syndrome in humans after young adulthood. There is a paucity of data in models mimicking chronic diet-induced changes in human middle age and interventions to reverse these changes. This study measured the changes during chronic consumption of a high-carbohydrate (as cornstarch), low-fat (C) diet and a high-carbohydrate (as fructose and sucrose), high-fat (H) diet in rats for 32 wk. C diet feeding induced changes without metabolic syndrome, such as disproportionate increases in total body lean and fat mass, reduced bone mineral content, cardiovascular remodeling with increased systolic blood pressure, left ventricular and arterial stiffness, and increased plasma markers of liver injury. H diet feeding induced visceral adiposity with reduced lean mass, increased lipid infiltration in the skeletal muscle, impaired glucose and insulin tolerance, cardiovascular remodeling, hepatic steatosis, and increased infiltration of inflammatory cells in the heart and the liver. Chia seed supplementation for 24 wk attenuated most structural and functional modifications induced by age or H diet, including increased whole body lean mass and lipid redistribution from the abdominal area, and normalized the chronic low-grade inflammation induced by H diet feeding; these effects may be mediated by increased metabolism of anti-inflammatory n-3 fatty acids from chia seed. These results suggest that chronic H diet feeding for 32 wk mimics the diet-induced cardiovascular and metabolic changes in middle age and that chia seed may serve as an alternative dietary strategy in the management of these changes. SN - 1522-1555 UR - https://www.unboundmedicine.com/medline/citation/22436699/Chronic_high_carbohydrate_high_fat_feeding_in_rats_induces_reversible_metabolic_cardiovascular_and_liver_changes_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00102.2012?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -