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Degree of bile-duct dilatation in liver-transplanted patients with biliary stricture: a magnetic resonance cholangiography-based study.

Abstract

PURPOSE

This study assessed whether the degree of bile-duct dilatation in liver-transplanted patients is correlated with the time from intervention and the type of underlying biliary stricture.

METHODS AND MATERIALS

Fifty-seven 3D magnetic resonance cholangiograms (MRCs) performed on 42 liver-transplanted patients were retrospectively evaluated. Diameter was measured at the level of the extrahepatic bile duct (EBD), right hepatic duct (RHD), left hepatic duct (LHD), anterior and posterior right hepatic ducts (aRHD, pRHD) and left lateral and medial ducts (LLD, LMD). Data were stratified according to the type of biliary stricture (all types, anastomotic, ischaemic-like, mixed) and compared, on a per-examination basis: (a) between two groups based on time from transplantation using a 1-year threshold (nonlongitudinal analysis); (b) among 26 repeated examinations on 11 patients (longitudinal analysis); (c) among different stricture groups.

RESULTS

The biliary tree was slightly dilated within 1 year from transplantation (2.9±1.3 to 6.1±3.2 mm). In general, nonlongitudinal analysis showed minimally larger duct size after 1 year (mean +1.4±0.5 mm) despite significant differences at most sites of measurement considering all types of strictures (p<0.01; Mann-Whitney U test). Longitudinal analysis showed diameter increase over time, although without statistically significant differences (p>0.01; Kruskal-Wallis test). No significant difference in bile-duct size was observed when comparing types of stricture (p>0.01; Kruskal-Wallis test).

CONCLUSIONS

Biliary dilatation after liver transplantation is mild and develops slowly regardless of the underlying type of stricture, possibly in relation to graft properties. MRC has a potential role as first-line imaging modality for a reliable assessment of biliary dilatation and the presence of a stricture.

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  • Authors+Show Affiliations

    ,

    Istituto di Radiologia Diagnostica, Dipartimento di Scienze Mediche Sperimentali e Cliniche, Università di Udine, Via Colugna 50, 33100, Udine, Italy. rgirometti@sirm.org

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    Source

    La Radiologia medica 117:7 2012 Oct pg 1097-111

    MeSH

    Adult
    Aged
    Bile Ducts
    Cholangiopancreatography, Magnetic Resonance
    Constriction, Pathologic
    Female
    Humans
    Liver Transplantation
    Male
    Middle Aged
    Retrospective Studies
    Statistics, Nonparametric

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22438111

    Citation

    Girometti, R, et al. "Degree of Bile-duct Dilatation in Liver-transplanted Patients With Biliary Stricture: a Magnetic Resonance Cholangiography-based Study." La Radiologia Medica, vol. 117, no. 7, 2012, pp. 1097-111.
    Girometti R, Molinari C, Del Pin M, et al. Degree of bile-duct dilatation in liver-transplanted patients with biliary stricture: a magnetic resonance cholangiography-based study. Radiol Med. 2012;117(7):1097-111.
    Girometti, R., Molinari, C., Del Pin, M., Toniutto, P., Bitetto, D., Como, G., ... Bazzocchi, M. (2012). Degree of bile-duct dilatation in liver-transplanted patients with biliary stricture: a magnetic resonance cholangiography-based study. La Radiologia Medica, 117(7), pp. 1097-111. doi:10.1007/s11547-012-0805-1.
    Girometti R, et al. Degree of Bile-duct Dilatation in Liver-transplanted Patients With Biliary Stricture: a Magnetic Resonance Cholangiography-based Study. Radiol Med. 2012;117(7):1097-111. PubMed PMID: 22438111.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Degree of bile-duct dilatation in liver-transplanted patients with biliary stricture: a magnetic resonance cholangiography-based study. AU - Girometti,R, AU - Molinari,C, AU - Del Pin,M, AU - Toniutto,P, AU - Bitetto,D, AU - Como,G, AU - Zuiani,C, AU - Bazzocchi,M, Y1 - 2012/03/19/ PY - 2011/02/26/received PY - 2011/04/27/accepted PY - 2012/3/23/entrez PY - 2012/3/23/pubmed PY - 2013/1/5/medline SP - 1097 EP - 111 JF - La Radiologia medica JO - Radiol Med VL - 117 IS - 7 N2 - PURPOSE: This study assessed whether the degree of bile-duct dilatation in liver-transplanted patients is correlated with the time from intervention and the type of underlying biliary stricture. METHODS AND MATERIALS: Fifty-seven 3D magnetic resonance cholangiograms (MRCs) performed on 42 liver-transplanted patients were retrospectively evaluated. Diameter was measured at the level of the extrahepatic bile duct (EBD), right hepatic duct (RHD), left hepatic duct (LHD), anterior and posterior right hepatic ducts (aRHD, pRHD) and left lateral and medial ducts (LLD, LMD). Data were stratified according to the type of biliary stricture (all types, anastomotic, ischaemic-like, mixed) and compared, on a per-examination basis: (a) between two groups based on time from transplantation using a 1-year threshold (nonlongitudinal analysis); (b) among 26 repeated examinations on 11 patients (longitudinal analysis); (c) among different stricture groups. RESULTS: The biliary tree was slightly dilated within 1 year from transplantation (2.9±1.3 to 6.1±3.2 mm). In general, nonlongitudinal analysis showed minimally larger duct size after 1 year (mean +1.4±0.5 mm) despite significant differences at most sites of measurement considering all types of strictures (p<0.01; Mann-Whitney U test). Longitudinal analysis showed diameter increase over time, although without statistically significant differences (p>0.01; Kruskal-Wallis test). No significant difference in bile-duct size was observed when comparing types of stricture (p>0.01; Kruskal-Wallis test). CONCLUSIONS: Biliary dilatation after liver transplantation is mild and develops slowly regardless of the underlying type of stricture, possibly in relation to graft properties. MRC has a potential role as first-line imaging modality for a reliable assessment of biliary dilatation and the presence of a stricture. SN - 1826-6983 UR - https://www.unboundmedicine.com/medline/citation/22438111/Degree_of_bile_duct_dilatation_in_liver_transplanted_patients_with_biliary_stricture:_a_magnetic_resonance_cholangiography_based_study_ L2 - https://dx.doi.org/10.1007/s11547-012-0805-1 DB - PRIME DP - Unbound Medicine ER -