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Possible effects of insulin-like growth factor-I, IGF-binding protein-3 and IGF-1/IGFBP-3 molar ratio on mammographic density: a cross-sectional study.
Eur J Gynaecol Oncol 2012; 33(1):74-8EJ

Abstract

The purpose of this study was to examine the possible effects of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio on mammographic density and assess whether this relationship was similar in subgroups of pre- and postmenopausal women. A group of 341 Italian women of childbearing age or naturally postmenopausal who had performed mammographic examination at the section of radiology of our department a maximum three months prior to recruitment were enrolled. A blood sample was drawn for determination of IGF-1, IGFBP-3 levels and IGF-1/IGFBP-3 molar ratio was calculated. On the basis of recent mammograms the women were divided into two groups: dense breast (DB) and non-dense breast (NDB). To assess the association between mammographic density and IGF-1, IGFBP-3 and Molar ratio Student's t-test was employed before and after stratified by menopausal status. The analysis of the relationship between mammographic density and plasma levels of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio showed that IGF-1 levels and molar ratio varied in the two groups resulting in higher mean values in the DB group whereas IGFBP-3 showed similar values in both groups (DB and NDB). After stratification of the study population by menopausal status, no association was found. Our study provides strong evidence of a crude association between breast density, and plasma levels of IGF-1 and molar ratio. IGF-1 and molar ratio might increase mammographic density and thus the risk of developing breast cancer.

Authors+Show Affiliations

Department of Obstetric and Gynaecological Sciences and Urological Sciences, Sapienza University of Rome, Italy. marialetizia.meggiorini@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22439410

Citation

Meggiorini, M L., et al. "Possible Effects of Insulin-like Growth factor-I, IGF-binding Protein-3 and IGF-1/IGFBP-3 Molar Ratio On Mammographic Density: a Cross-sectional Study." European Journal of Gynaecological Oncology, vol. 33, no. 1, 2012, pp. 74-8.
Meggiorini ML, Cipolla V, Borgoni G, et al. Possible effects of insulin-like growth factor-I, IGF-binding protein-3 and IGF-1/IGFBP-3 molar ratio on mammographic density: a cross-sectional study. Eur J Gynaecol Oncol. 2012;33(1):74-8.
Meggiorini, M. L., Cipolla, V., Borgoni, G., Nofroni, I., Pala, A., & de Felice, C. (2012). Possible effects of insulin-like growth factor-I, IGF-binding protein-3 and IGF-1/IGFBP-3 molar ratio on mammographic density: a cross-sectional study. European Journal of Gynaecological Oncology, 33(1), pp. 74-8.
Meggiorini ML, et al. Possible Effects of Insulin-like Growth factor-I, IGF-binding Protein-3 and IGF-1/IGFBP-3 Molar Ratio On Mammographic Density: a Cross-sectional Study. Eur J Gynaecol Oncol. 2012;33(1):74-8. PubMed PMID: 22439410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible effects of insulin-like growth factor-I, IGF-binding protein-3 and IGF-1/IGFBP-3 molar ratio on mammographic density: a cross-sectional study. AU - Meggiorini,M L, AU - Cipolla,V, AU - Borgoni,G, AU - Nofroni,I, AU - Pala,A, AU - de Felice,C, PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/5/4/medline SP - 74 EP - 8 JF - European journal of gynaecological oncology JO - Eur. J. Gynaecol. Oncol. VL - 33 IS - 1 N2 - The purpose of this study was to examine the possible effects of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio on mammographic density and assess whether this relationship was similar in subgroups of pre- and postmenopausal women. A group of 341 Italian women of childbearing age or naturally postmenopausal who had performed mammographic examination at the section of radiology of our department a maximum three months prior to recruitment were enrolled. A blood sample was drawn for determination of IGF-1, IGFBP-3 levels and IGF-1/IGFBP-3 molar ratio was calculated. On the basis of recent mammograms the women were divided into two groups: dense breast (DB) and non-dense breast (NDB). To assess the association between mammographic density and IGF-1, IGFBP-3 and Molar ratio Student's t-test was employed before and after stratified by menopausal status. The analysis of the relationship between mammographic density and plasma levels of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio showed that IGF-1 levels and molar ratio varied in the two groups resulting in higher mean values in the DB group whereas IGFBP-3 showed similar values in both groups (DB and NDB). After stratification of the study population by menopausal status, no association was found. Our study provides strong evidence of a crude association between breast density, and plasma levels of IGF-1 and molar ratio. IGF-1 and molar ratio might increase mammographic density and thus the risk of developing breast cancer. SN - 0392-2936 UR - https://www.unboundmedicine.com/medline/citation/22439410/Possible_effects_of_insulin_like_growth_factor_I_IGF_binding_protein_3_and_IGF_1/IGFBP_3_molar_ratio_on_mammographic_density:_a_cross_sectional_study_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -