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Atypical polypoid adenomyoma of the uterus. A case report and a review of the literature.
Eur J Gynaecol Oncol. 2012; 33(1):118-21.EJ

Abstract

Atypical polypoid adenomyoma (APA) is a rare, benign lesion. The tumor occurs in nulliparous women aged 22-48 years (average 33 years) and it has been suggested as being related to prolonged estrogenic stimulation. We describe a case of a 72-year-old woman who presented at our hospital with persistent, worsening urinary incontinence and pelvic pain. Physical examination and pelvic ultrasound disclosed uterine enlargement, a mass in the endometrial cavity and multiple small myomas. Total hysterectomy with bilateral salpingo-oophorectomy was performed. The histological diagnosis for the mass of the endometrial cavity was atypical polypoid adenomyoma. APA should be distinguished from endometrial carcinoma and other malignant uterine neoplasms such as adenofibroma, adenosarcoma and malignant mixed mullerian tumor. The immunohistochemical panel which usually includes alpha smooth muscle actin, desmin, Ki67 and recently CD10 is often helpful in establishing the diagnosis. The treatment may vary depending on the patient's age, her desire to preserve fertility, and the severity of her symptoms.

Authors+Show Affiliations

Department of Pathology, Tzaneion General Hospital of Pireaus, Piraeus, Greece. adserbet@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

22439420

Citation

Zizi-Sermpetzoglou, A, et al. "Atypical Polypoid Adenomyoma of the Uterus. a Case Report and a Review of the Literature." European Journal of Gynaecological Oncology, vol. 33, no. 1, 2012, pp. 118-21.
Zizi-Sermpetzoglou A, Moustou E, Petrakopoulou N, et al. Atypical polypoid adenomyoma of the uterus. A case report and a review of the literature. Eur J Gynaecol Oncol. 2012;33(1):118-21.
Zizi-Sermpetzoglou, A., Moustou, E., Petrakopoulou, N., Arkoumani, E., Tepelenis, N., & Savvaidou, V. (2012). Atypical polypoid adenomyoma of the uterus. A case report and a review of the literature. European Journal of Gynaecological Oncology, 33(1), 118-21.
Zizi-Sermpetzoglou A, et al. Atypical Polypoid Adenomyoma of the Uterus. a Case Report and a Review of the Literature. Eur J Gynaecol Oncol. 2012;33(1):118-21. PubMed PMID: 22439420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical polypoid adenomyoma of the uterus. A case report and a review of the literature. AU - Zizi-Sermpetzoglou,A, AU - Moustou,E, AU - Petrakopoulou,N, AU - Arkoumani,E, AU - Tepelenis,N, AU - Savvaidou,V, PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/5/4/medline SP - 118 EP - 21 JF - European journal of gynaecological oncology JO - Eur J Gynaecol Oncol VL - 33 IS - 1 N2 - Atypical polypoid adenomyoma (APA) is a rare, benign lesion. The tumor occurs in nulliparous women aged 22-48 years (average 33 years) and it has been suggested as being related to prolonged estrogenic stimulation. We describe a case of a 72-year-old woman who presented at our hospital with persistent, worsening urinary incontinence and pelvic pain. Physical examination and pelvic ultrasound disclosed uterine enlargement, a mass in the endometrial cavity and multiple small myomas. Total hysterectomy with bilateral salpingo-oophorectomy was performed. The histological diagnosis for the mass of the endometrial cavity was atypical polypoid adenomyoma. APA should be distinguished from endometrial carcinoma and other malignant uterine neoplasms such as adenofibroma, adenosarcoma and malignant mixed mullerian tumor. The immunohistochemical panel which usually includes alpha smooth muscle actin, desmin, Ki67 and recently CD10 is often helpful in establishing the diagnosis. The treatment may vary depending on the patient's age, her desire to preserve fertility, and the severity of her symptoms. SN - 0392-2936 UR - https://www.unboundmedicine.com/medline/citation/22439420/Atypical_polypoid_adenomyoma_of_the_uterus__A_case_report_and_a_review_of_the_literature_ L2 - https://medlineplus.gov/uterinecancer.html DB - PRIME DP - Unbound Medicine ER -