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Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology.
Autoimmun Rev. 2012 Oct; 11(12):863-72.AR

Abstract

Anti-NMDAR encephalitis is a newly characterized syndrome with a progressive, predictable clinical course and the possibility of effective treatment. Accurate and timely diagnosis is critical to selection and implementation of treatments, and optimal patient outcomes. Outcomes are improved with early diagnosis via indirect immunofluorescence or cell-based assays, and the rapid and appropriate administration of immunosuppressant and anti-psychotic therapies. Three possible scenarios accounting for the immunopathogenesis of anti-NMDAR encephalitis are presented, with the most probable one being that of paraneoplastic autoimmunity. Future efforts in this disorder should focus on elucidating the mechanisms that contribute to initiation of this antibody response, as well as exploring the role of tumors, infectious triggers and immune-reactivation. Finally, accessible tools need to be developed that allow for reliable identification of specific antibody markers against synaptic proteins.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Division of Reproductive Biology, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5. peeryh@mcmaster.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22440397

Citation

Peery, Harry E., et al. "Anti-NMDA Receptor Encephalitis. the Disorder, the Diagnosis and the Immunobiology." Autoimmunity Reviews, vol. 11, no. 12, 2012, pp. 863-72.
Peery HE, Day GS, Dunn S, et al. Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmun Rev. 2012;11(12):863-72.
Peery, H. E., Day, G. S., Dunn, S., Fritzler, M. J., Prüss, H., De Souza, C., Doja, A., Mossman, K., Resch, L., Xia, C., Sakic, B., Belbeck, L., & Foster, W. G. (2012). Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmunity Reviews, 11(12), 863-72. https://doi.org/10.1016/j.autrev.2012.03.001
Peery HE, et al. Anti-NMDA Receptor Encephalitis. the Disorder, the Diagnosis and the Immunobiology. Autoimmun Rev. 2012;11(12):863-72. PubMed PMID: 22440397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. AU - Peery,Harry E, AU - Day,Gregory S, AU - Dunn,Shannon, AU - Fritzler,Marvin J, AU - Prüss,Harald, AU - De Souza,Claire, AU - Doja,Asif, AU - Mossman,Karen, AU - Resch,Lothar, AU - Xia,Chenjie, AU - Sakic,Boris, AU - Belbeck,Larry, AU - Foster,Warren G, Y1 - 2012/03/11/ PY - 2012/03/01/received PY - 2012/03/07/accepted PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2013/2/7/medline SP - 863 EP - 72 JF - Autoimmunity reviews JO - Autoimmun Rev VL - 11 IS - 12 N2 - Anti-NMDAR encephalitis is a newly characterized syndrome with a progressive, predictable clinical course and the possibility of effective treatment. Accurate and timely diagnosis is critical to selection and implementation of treatments, and optimal patient outcomes. Outcomes are improved with early diagnosis via indirect immunofluorescence or cell-based assays, and the rapid and appropriate administration of immunosuppressant and anti-psychotic therapies. Three possible scenarios accounting for the immunopathogenesis of anti-NMDAR encephalitis are presented, with the most probable one being that of paraneoplastic autoimmunity. Future efforts in this disorder should focus on elucidating the mechanisms that contribute to initiation of this antibody response, as well as exploring the role of tumors, infectious triggers and immune-reactivation. Finally, accessible tools need to be developed that allow for reliable identification of specific antibody markers against synaptic proteins. SN - 1873-0183 UR - https://www.unboundmedicine.com/medline/citation/22440397/Anti_NMDA_receptor_encephalitis__The_disorder_the_diagnosis_and_the_immunobiology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(12)00061-4 DB - PRIME DP - Unbound Medicine ER -