Tags

Type your tag names separated by a space and hit enter

Impacts of conventional coronary risk factors, diabetes and hypertension, on coronary atherosclerosis during statin therapy: subanalysis of the TRUTH study.
Coron Artery Dis. 2012 Jun; 23(4):239-44.CA

Abstract

OBJECTIVE

Patients with diabetes mellitus (DM) and hypertension (HT) are at a high risk of coronary artery disease. However, the mechanisms underlying this have not been well characterized. The purpose of the present study was to evaluate the impacts of DM and HT on coronary atherosclerosis during statin therapy.

MATERIALS AND METHODS

The effects of 8-month statin therapy on coronary atherosclerosis were evaluated in the TRUTH study using virtual histology intravascular ultrasound. Analyzable intravascular ultrasound data were obtained from 119 patients who were divided into four subgroups, namely, group A: DM (+), HT (+); group B: DM (+), HT (-); group C: DM (-), HT (+); and group D: DM (-), HT (-). The pattern of arterial remodeling, extent of coronary atherosclerosis, and plaque composition were compared among the four subgroups.

RESULTS

Atheroma volume decreased significantly in group D (-3.9%, P=0.01), whereas it tended to increase in group A (1.0%, P=0.77). A significant difference in the mean percent change of atheroma volume was observed between groups A and D (1.0 vs. -3.9%, P=0.03). Furthermore, the frequency of progression in atheroma volume was significantly higher in group A (60, 33, 45, and 24% in groups A, B, C, and D, respectively; P=0.03). No significant differences in the changes in the four plaque components among the four subgroups were observed.

CONCLUSION

A combination of DM and HT attenuates the degree of regression of coronary atherosclerosis, but does not influence changes in plaque composition during statin therapy.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Japan. nozue2493@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

22441135

Citation

Nozue, Tsuyoshi, et al. "Impacts of Conventional Coronary Risk Factors, Diabetes and Hypertension, On Coronary Atherosclerosis During Statin Therapy: Subanalysis of the TRUTH Study." Coronary Artery Disease, vol. 23, no. 4, 2012, pp. 239-44.
Nozue T, Yamamoto S, Tohyama S, et al. Impacts of conventional coronary risk factors, diabetes and hypertension, on coronary atherosclerosis during statin therapy: subanalysis of the TRUTH study. Coron Artery Dis. 2012;23(4):239-44.
Nozue, T., Yamamoto, S., Tohyama, S., Fukui, K., Umezawa, S., Onishi, Y., Kunishima, T., Sato, A., Nozato, T., Miyake, S., Takeyama, Y., Morino, Y., Yamauchi, T., Hibi, K., Terashima, M., & Michishita, I. (2012). Impacts of conventional coronary risk factors, diabetes and hypertension, on coronary atherosclerosis during statin therapy: subanalysis of the TRUTH study. Coronary Artery Disease, 23(4), 239-44. https://doi.org/10.1097/MCA.0b013e328351f919
Nozue T, et al. Impacts of Conventional Coronary Risk Factors, Diabetes and Hypertension, On Coronary Atherosclerosis During Statin Therapy: Subanalysis of the TRUTH Study. Coron Artery Dis. 2012;23(4):239-44. PubMed PMID: 22441135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impacts of conventional coronary risk factors, diabetes and hypertension, on coronary atherosclerosis during statin therapy: subanalysis of the TRUTH study. AU - Nozue,Tsuyoshi, AU - Yamamoto,Shingo, AU - Tohyama,Shinichi, AU - Fukui,Kazuki, AU - Umezawa,Shigeo, AU - Onishi,Yuko, AU - Kunishima,Tomoyuki, AU - Sato,Akira, AU - Nozato,Toshihiro, AU - Miyake,Shogo, AU - Takeyama,Youichi, AU - Morino,Yoshihiro, AU - Yamauchi,Takao, AU - Hibi,Kiyoshi, AU - Terashima,Mitsuyasu, AU - Michishita,Ichiro, AU - ,, PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/8/31/medline SP - 239 EP - 44 JF - Coronary artery disease JO - Coron Artery Dis VL - 23 IS - 4 N2 - OBJECTIVE: Patients with diabetes mellitus (DM) and hypertension (HT) are at a high risk of coronary artery disease. However, the mechanisms underlying this have not been well characterized. The purpose of the present study was to evaluate the impacts of DM and HT on coronary atherosclerosis during statin therapy. MATERIALS AND METHODS: The effects of 8-month statin therapy on coronary atherosclerosis were evaluated in the TRUTH study using virtual histology intravascular ultrasound. Analyzable intravascular ultrasound data were obtained from 119 patients who were divided into four subgroups, namely, group A: DM (+), HT (+); group B: DM (+), HT (-); group C: DM (-), HT (+); and group D: DM (-), HT (-). The pattern of arterial remodeling, extent of coronary atherosclerosis, and plaque composition were compared among the four subgroups. RESULTS: Atheroma volume decreased significantly in group D (-3.9%, P=0.01), whereas it tended to increase in group A (1.0%, P=0.77). A significant difference in the mean percent change of atheroma volume was observed between groups A and D (1.0 vs. -3.9%, P=0.03). Furthermore, the frequency of progression in atheroma volume was significantly higher in group A (60, 33, 45, and 24% in groups A, B, C, and D, respectively; P=0.03). No significant differences in the changes in the four plaque components among the four subgroups were observed. CONCLUSION: A combination of DM and HT attenuates the degree of regression of coronary atherosclerosis, but does not influence changes in plaque composition during statin therapy. SN - 1473-5830 UR - https://www.unboundmedicine.com/medline/citation/22441135/Impacts_of_conventional_coronary_risk_factors_diabetes_and_hypertension_on_coronary_atherosclerosis_during_statin_therapy:_subanalysis_of_the_TRUTH_study_ L2 - https://doi.org/10.1097/MCA.0b013e328351f919 DB - PRIME DP - Unbound Medicine ER -