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An unusual histologic variant of necrobiotic xanthogranuloma.

Abstract

Necrobiotic xanthogranuloma (NXG) usually shows a stereotypical histopathologic presentation. However, few unusual cases have been published. We present a patient with NXG showing exceptional histopathologic features. NXG in our patient presents with exclusively dermal granulomatous inflammation mimicking interstitial granuloma annulare. Not only subcutaneous involvement, but also, evident zones of degenerated collagen, foam cells, and cholesterol clefts were missing. Moreover, the case shows overlaps with recently published granulomatous scleromyxedema. Some common clinical and histopathologic features of NXG and scleromyxedema might be based on shared underlying paraproteinemia.

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    • Authors+Show Affiliations

    Ziemer M
    ,

    Department of Dermatology, Venereology, and Allergology, University Hospital of Leipzig, Philipp-Rosenthal-Str. 23–25, Leipzig, Germany. mirjana.ziemer@medizin.uni-leipzig.de

    Norgauer J
    ,
    Simon JC
    ,
    Koehler MJ

    Source

    MeSH

    Female
    Humans
    Immunoglobulins, Intravenous
    Middle Aged
    Monoclonal Gammopathy of Undetermined Significance
    Necrobiotic Xanthogranuloma

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    22441374

    Citation

    Ziemer, Mirjana, et al. "An Unusual Histologic Variant of Necrobiotic Xanthogranuloma." The American Journal of Dermatopathology, vol. 34, no. 2, 2012, pp. e22-6.
    Ziemer M, Norgauer J, Simon JC, et al. An unusual histologic variant of necrobiotic xanthogranuloma. Am J Dermatopathol. 2012;34(2):e22-6.
    Ziemer, M., Norgauer, J., Simon, J. C., & Koehler, M. J. (2012). An unusual histologic variant of necrobiotic xanthogranuloma. The American Journal of Dermatopathology, 34(2), pp. e22-6. doi:10.1097/DAD.0b013e3182222aa8.
    Ziemer M, et al. An Unusual Histologic Variant of Necrobiotic Xanthogranuloma. Am J Dermatopathol. 2012;34(2):e22-6. PubMed PMID: 22441374.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An unusual histologic variant of necrobiotic xanthogranuloma. AU - Ziemer,Mirjana, AU - Norgauer,Johannes, AU - Simon,Jan-Christoph, AU - Koehler,Martin Johannes, PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/7/21/medline SP - e22 EP - 6 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 34 IS - 2 N2 - Necrobiotic xanthogranuloma (NXG) usually shows a stereotypical histopathologic presentation. However, few unusual cases have been published. We present a patient with NXG showing exceptional histopathologic features. NXG in our patient presents with exclusively dermal granulomatous inflammation mimicking interstitial granuloma annulare. Not only subcutaneous involvement, but also, evident zones of degenerated collagen, foam cells, and cholesterol clefts were missing. Moreover, the case shows overlaps with recently published granulomatous scleromyxedema. Some common clinical and histopathologic features of NXG and scleromyxedema might be based on shared underlying paraproteinemia. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/22441374/An_unusual_histologic_variant_of_necrobiotic_xanthogranuloma_ L2 - http://Insights.ovid.com/pubmed?pmid=22441374 DB - PRIME DP - Unbound Medicine ER -