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Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab).
J Clin Endocrinol Metab. 2012 Jun; 97(6):1953-61.JC

Abstract

CONTEXT

Serum 25-hydroxyvitamin D [25(OH)D] concentration has been inversely associated with the prevalence of metabolic syndrome (MetS), but the relationship between 25(OH)D and incident MetS remains unclear.

OBJECTIVE

We evaluated the prospective association between 25(OH)D, MetS, and its components in a large population-based cohort of adults aged 25 yr or older.

DESIGN

We used baseline (1999-2000) and 5-yr follow-up data of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab).

PARTICIPANTS

Of the 11,247 adults evaluated at baseline, 6,537 returned for follow-up. We studied those without MetS at baseline and with complete data (n = 4164; mean age 50 yr; 58% women; 92% Europids).

OUTCOME MEASURES

We report the associations between baseline 25(OH)D and 5-yr MetS incidence and its components, adjusted for age, sex, ethnicity, season, latitude, smoking, family history of type 2 diabetes, physical activity, education, kidney function, waist circumference (WC), and baseline MetS components.

RESULTS

A total of 528 incident cases (12.7%) of MetS developed over 5 yr. Compared with those in the highest quintile of 25(OH)D (≥34 ng/ml), MetS risk was significantly higher in people with 25(OH)D in the first (<18 ng/ml) and second (18-23 ng/ml) quintiles; odds ratio (95% confidence interval) = 1.41 (1.02-1.95) and 1.74 (1.28-2.37), respectively. Serum 25(OH)D was inversely associated with 5-yr WC (P < 0.001), triglycerides (P < 0.01), fasting glucose (P < 0.01), and homeostasis model assessment for insulin resistance (P < 0.001) but not with 2-h plasma glucose (P = 0.29), high-density lipoprotein cholesterol (P = 0.70), or blood pressure (P = 0.46).

CONCLUSIONS

In Australian adults, lower 25(OH)D concentrations were associated with increased MetS risk and higher WC, serum triglyceride, fasting glucose, and insulin resistance at 5 yr. Vitamin D supplementation studies are required to establish whether the link between vitamin D deficiency and MetS is causal.

Authors+Show Affiliations

Centre hospitalier Universitaire de Québec, Centre hospitalier de l'Université Laval, Laval University, 2705 Boulevard Laurier, Québec, Canada G1V 4G2. claudia.gagnon@crchuq.ulaval.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22442263

Citation

Gagnon, Claudia, et al. "Low Serum 25-hydroxyvitamin D Is Associated With Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results From a National, Population-based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab)." The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 6, 2012, pp. 1953-61.
Gagnon C, Lu ZX, Magliano DJ, et al. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab. 2012;97(6):1953-61.
Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P. Z., Sikaris, K., Ebeling, P. R., & Daly, R. M. (2012). Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). The Journal of Clinical Endocrinology and Metabolism, 97(6), 1953-61. https://doi.org/10.1210/jc.2011-3187
Gagnon C, et al. Low Serum 25-hydroxyvitamin D Is Associated With Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results From a National, Population-based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab. 2012;97(6):1953-61. PubMed PMID: 22442263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). AU - Gagnon,Claudia, AU - Lu,Zhong X, AU - Magliano,Dianna J, AU - Dunstan,David W, AU - Shaw,Jonathan E, AU - Zimmet,Paul Z, AU - Sikaris,Ken, AU - Ebeling,Peter R, AU - Daly,Robin M, Y1 - 2012/03/22/ PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/8/16/medline SP - 1953 EP - 61 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 97 IS - 6 N2 - CONTEXT: Serum 25-hydroxyvitamin D [25(OH)D] concentration has been inversely associated with the prevalence of metabolic syndrome (MetS), but the relationship between 25(OH)D and incident MetS remains unclear. OBJECTIVE: We evaluated the prospective association between 25(OH)D, MetS, and its components in a large population-based cohort of adults aged 25 yr or older. DESIGN: We used baseline (1999-2000) and 5-yr follow-up data of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). PARTICIPANTS: Of the 11,247 adults evaluated at baseline, 6,537 returned for follow-up. We studied those without MetS at baseline and with complete data (n = 4164; mean age 50 yr; 58% women; 92% Europids). OUTCOME MEASURES: We report the associations between baseline 25(OH)D and 5-yr MetS incidence and its components, adjusted for age, sex, ethnicity, season, latitude, smoking, family history of type 2 diabetes, physical activity, education, kidney function, waist circumference (WC), and baseline MetS components. RESULTS: A total of 528 incident cases (12.7%) of MetS developed over 5 yr. Compared with those in the highest quintile of 25(OH)D (≥34 ng/ml), MetS risk was significantly higher in people with 25(OH)D in the first (<18 ng/ml) and second (18-23 ng/ml) quintiles; odds ratio (95% confidence interval) = 1.41 (1.02-1.95) and 1.74 (1.28-2.37), respectively. Serum 25(OH)D was inversely associated with 5-yr WC (P < 0.001), triglycerides (P < 0.01), fasting glucose (P < 0.01), and homeostasis model assessment for insulin resistance (P < 0.001) but not with 2-h plasma glucose (P = 0.29), high-density lipoprotein cholesterol (P = 0.70), or blood pressure (P = 0.46). CONCLUSIONS: In Australian adults, lower 25(OH)D concentrations were associated with increased MetS risk and higher WC, serum triglyceride, fasting glucose, and insulin resistance at 5 yr. Vitamin D supplementation studies are required to establish whether the link between vitamin D deficiency and MetS is causal. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/22442263/Low_serum_25_hydroxyvitamin_D_is_associated_with_increased_risk_of_the_development_of_the_metabolic_syndrome_at_five_years:_results_from_a_national_population_based_prospective_study__The_Australian_Diabetes_Obesity_and_Lifestyle_Study:_AusDiab__ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-3187 DB - PRIME DP - Unbound Medicine ER -