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In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells.
Bull Exp Biol Med. 2011 May; 151(1):30-2.BE

Abstract

We studied the effects of endocannabinoid anandamide and its cyclooxygenase derivative prostamide E2 on cultured cerebellar granular cells and C6 glioma cells from rats. Prostamide E2 prevented apoptosis in cerebellar neurons induced by potassium deprivation of cultures, while anandamide had no neuroprotective properties. Prostamide E2 did not modulate the survival rate of glioma cells, while anandamide produced a cytotoxic effect. Our results indicate that cyclooxygenase transformation of anandamide is followed by the loss of antitumor activity of this agent. By contrast, prostamide E2 exhibited strong neuroprotective properties.

Authors+Show Affiliations

Laboratory of Experimental Neurocytology, Neurology Research Center, Russian Academy of Medical Sciences, Moscow, Russia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22442796

Citation

Andrianova, E L., et al. "In Vitro Effects of Anandamide and Prostamide E2 On Normal and Transformed Nerve Cells." Bulletin of Experimental Biology and Medicine, vol. 151, no. 1, 2011, pp. 30-2.
Andrianova EL, Genrikhs EE, Bobrov MY, et al. In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. Bull Exp Biol Med. 2011;151(1):30-2.
Andrianova, E. L., Genrikhs, E. E., Bobrov, M. Y., Lizhin, A. A., Gretskaya, N. M., Frumkina, L. E., Khaspekov, L. G., & Bezuglov, V. V. (2011). In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. Bulletin of Experimental Biology and Medicine, 151(1), 30-2.
Andrianova EL, et al. In Vitro Effects of Anandamide and Prostamide E2 On Normal and Transformed Nerve Cells. Bull Exp Biol Med. 2011;151(1):30-2. PubMed PMID: 22442796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. AU - Andrianova,E L, AU - Genrikhs,E E, AU - Bobrov,M Yu, AU - Lizhin,A A, AU - Gretskaya,N M, AU - Frumkina,L E, AU - Khaspekov,L G, AU - Bezuglov,V V, PY - 2012/3/24/entrez PY - 2012/3/24/pubmed PY - 2012/7/7/medline SP - 30 EP - 2 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 151 IS - 1 N2 - We studied the effects of endocannabinoid anandamide and its cyclooxygenase derivative prostamide E2 on cultured cerebellar granular cells and C6 glioma cells from rats. Prostamide E2 prevented apoptosis in cerebellar neurons induced by potassium deprivation of cultures, while anandamide had no neuroprotective properties. Prostamide E2 did not modulate the survival rate of glioma cells, while anandamide produced a cytotoxic effect. Our results indicate that cyclooxygenase transformation of anandamide is followed by the loss of antitumor activity of this agent. By contrast, prostamide E2 exhibited strong neuroprotective properties. SN - 1573-8221 UR - https://www.unboundmedicine.com/medline/citation/22442796/In_vitro_effects_of_anandamide_and_prostamide_e2_on_normal_and_transformed_nerve_cells_ L2 - https://dx.doi.org/10.1007/s10517-011-1252-9 DB - PRIME DP - Unbound Medicine ER -