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Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men.
Metabolism. 2012 Sep; 61(9):1270-9.M

Abstract

Heart rate variability (HRV) is affected by age, hyperglycemia and accumulation of body fat. This study compares the predictive value of four measurements of adiposity/obesity on HRV and investigates the specific role of age, metabolic contributors and degree/distribution of fat in HRV alterations. The sample consisted of 97 non-diabetic and non-medicated men with features of the metabolic syndrome (50±8 years of age, body mass index [BMI] 31±3 kg/m(2), waist circumference [WC] 107±9 cm, triglycerides 2.3±0.7 mmol/L, fasting glucose 6.0±0.5 mmol/L, insulin 156±71 pmol/L; mean±SD). WC, BMI, percent body fat (% fat, from dual energy X-ray absorptiometry) and visceral adipose tissue volume (VAT, from computed tomography) were used as measures of adiposity/obesity. HRV measures were obtained from 24-h, day- and night-time segments of Holter recordings. BMI presented no independent association with HRV. Percentage fat was the strongest obesity index to be associated with HRV: 24-h pNN50, rMSSD, HF and daytime pNN50, rMSSD, HF and LF (-0.27≤std β≤-0.20, P<.05). VAT was associated with 24-h SDNN, LF (std β=-0.25 and -0.20, P<.05, respectively) and daytime SDNN (std β=-0.24, P<.05) while WC was associated with nighttime SDNN and SDANN (std β=0.22 and 0.32, P<.05). In addition, age, fasting glucose, 2-h oral glucose tolerance test and triglycerides presented independent association with HRV. Adiposity/obesity measurements seem to be differently associated with HRV. An approach considering the combination of age, obesity and glucose metabolism factors could be helpful in the global cardiovascular risk management in abdominally obese men.

Authors+Show Affiliations

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22444779

Citation

Poliakova, Natalia, et al. "Influence of Obesity Indices, Metabolic Parameters and Age On Cardiac Autonomic Function in Abdominally Obese Men." Metabolism: Clinical and Experimental, vol. 61, no. 9, 2012, pp. 1270-9.
Poliakova N, Després JP, Bergeron J, et al. Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men. Metabolism. 2012;61(9):1270-9.
Poliakova, N., Després, J. P., Bergeron, J., Alméras, N., Tremblay, A., & Poirier, P. (2012). Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men. Metabolism: Clinical and Experimental, 61(9), 1270-9. https://doi.org/10.1016/j.metabol.2012.02.006
Poliakova N, et al. Influence of Obesity Indices, Metabolic Parameters and Age On Cardiac Autonomic Function in Abdominally Obese Men. Metabolism. 2012;61(9):1270-9. PubMed PMID: 22444779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men. AU - Poliakova,Natalia, AU - Després,Jean-Pierre, AU - Bergeron,Jean, AU - Alméras,Natalie, AU - Tremblay,Angelo, AU - Poirier,Paul, Y1 - 2012/03/22/ PY - 2011/08/26/received PY - 2012/01/19/revised PY - 2012/02/09/accepted PY - 2012/3/27/entrez PY - 2012/3/27/pubmed PY - 2012/10/27/medline SP - 1270 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 61 IS - 9 N2 - Heart rate variability (HRV) is affected by age, hyperglycemia and accumulation of body fat. This study compares the predictive value of four measurements of adiposity/obesity on HRV and investigates the specific role of age, metabolic contributors and degree/distribution of fat in HRV alterations. The sample consisted of 97 non-diabetic and non-medicated men with features of the metabolic syndrome (50±8 years of age, body mass index [BMI] 31±3 kg/m(2), waist circumference [WC] 107±9 cm, triglycerides 2.3±0.7 mmol/L, fasting glucose 6.0±0.5 mmol/L, insulin 156±71 pmol/L; mean±SD). WC, BMI, percent body fat (% fat, from dual energy X-ray absorptiometry) and visceral adipose tissue volume (VAT, from computed tomography) were used as measures of adiposity/obesity. HRV measures were obtained from 24-h, day- and night-time segments of Holter recordings. BMI presented no independent association with HRV. Percentage fat was the strongest obesity index to be associated with HRV: 24-h pNN50, rMSSD, HF and daytime pNN50, rMSSD, HF and LF (-0.27≤std β≤-0.20, P<.05). VAT was associated with 24-h SDNN, LF (std β=-0.25 and -0.20, P<.05, respectively) and daytime SDNN (std β=-0.24, P<.05) while WC was associated with nighttime SDNN and SDANN (std β=0.22 and 0.32, P<.05). In addition, age, fasting glucose, 2-h oral glucose tolerance test and triglycerides presented independent association with HRV. Adiposity/obesity measurements seem to be differently associated with HRV. An approach considering the combination of age, obesity and glucose metabolism factors could be helpful in the global cardiovascular risk management in abdominally obese men. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/22444779/Influence_of_obesity_indices_metabolic_parameters_and_age_on_cardiac_autonomic_function_in_abdominally_obese_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(12)00075-3 DB - PRIME DP - Unbound Medicine ER -