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Amputation rate and risk factors in type 2 patients with diabetic foot syndrome under real-life conditions in Germany.
Prim Care Diabetes. 2012 Oct; 6(3):241-6.PC

Abstract

AIMS

To determine the risk of amputation and the influencing factors for amputation for patients with type 2 diabetes with diabetic foot syndrome.

METHODS

Longitudinal data from general practices in Germany (Disease Analyzer database, IMS Health) were analyzed. 3892 type 2 diabetes patients (mean age: 66.0 (SD: 10.9 years), 39.1% female) with a first-time diagnosis of diabetic foot syndrome between 01/200 and 12/2004 and at least 5 year follow-up documentation in the practices were included. The analyses of amputation-free survival were carried out using Kaplan-Meier curves and log-rank tests. A multivariate Cox regression model was fitted with the incident of diabetes-associated amputations as the dependent variable and adjusted for clinical and demographic characteristics.

RESULT

The cumulative incidence of diabetes-associated lower limb amputations was 18.2%. Amputations are independently associated with higher age, male gender, higher HbA1c value and longer diabetes duration but also some other diabetes complications.

DISCUSSION

The diabetic foot syndrome can but must not lead to a lower limb amputation. Due to the great medical and economic burden on the health system caused by diabetic complications, early therapeutic intervention is essential for patients with diabetic foot syndrome.

Authors+Show Affiliations

Department of Diabetology, Clinical Center Traunstein, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22445058

Citation

Pscherer, Stephan, et al. "Amputation Rate and Risk Factors in Type 2 Patients With Diabetic Foot Syndrome Under Real-life Conditions in Germany." Primary Care Diabetes, vol. 6, no. 3, 2012, pp. 241-6.
Pscherer S, Dippel FW, Lauterbach S, et al. Amputation rate and risk factors in type 2 patients with diabetic foot syndrome under real-life conditions in Germany. Prim Care Diabetes. 2012;6(3):241-6.
Pscherer, S., Dippel, F. W., Lauterbach, S., & Kostev, K. (2012). Amputation rate and risk factors in type 2 patients with diabetic foot syndrome under real-life conditions in Germany. Primary Care Diabetes, 6(3), 241-6. https://doi.org/10.1016/j.pcd.2012.02.004
Pscherer S, et al. Amputation Rate and Risk Factors in Type 2 Patients With Diabetic Foot Syndrome Under Real-life Conditions in Germany. Prim Care Diabetes. 2012;6(3):241-6. PubMed PMID: 22445058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amputation rate and risk factors in type 2 patients with diabetic foot syndrome under real-life conditions in Germany. AU - Pscherer,Stephan, AU - Dippel,Franz-Werner, AU - Lauterbach,Silke, AU - Kostev,Karel, Y1 - 2012/03/22/ PY - 2011/12/22/received PY - 2012/02/25/revised PY - 2012/02/28/accepted PY - 2012/3/27/entrez PY - 2012/3/27/pubmed PY - 2013/1/12/medline SP - 241 EP - 6 JF - Primary care diabetes JO - Prim Care Diabetes VL - 6 IS - 3 N2 - AIMS: To determine the risk of amputation and the influencing factors for amputation for patients with type 2 diabetes with diabetic foot syndrome. METHODS: Longitudinal data from general practices in Germany (Disease Analyzer database, IMS Health) were analyzed. 3892 type 2 diabetes patients (mean age: 66.0 (SD: 10.9 years), 39.1% female) with a first-time diagnosis of diabetic foot syndrome between 01/200 and 12/2004 and at least 5 year follow-up documentation in the practices were included. The analyses of amputation-free survival were carried out using Kaplan-Meier curves and log-rank tests. A multivariate Cox regression model was fitted with the incident of diabetes-associated amputations as the dependent variable and adjusted for clinical and demographic characteristics. RESULT: The cumulative incidence of diabetes-associated lower limb amputations was 18.2%. Amputations are independently associated with higher age, male gender, higher HbA1c value and longer diabetes duration but also some other diabetes complications. DISCUSSION: The diabetic foot syndrome can but must not lead to a lower limb amputation. Due to the great medical and economic burden on the health system caused by diabetic complications, early therapeutic intervention is essential for patients with diabetic foot syndrome. SN - 1878-0210 UR - https://www.unboundmedicine.com/medline/citation/22445058/Amputation_rate_and_risk_factors_in_type_2_patients_with_diabetic_foot_syndrome_under_real_life_conditions_in_Germany_ DB - PRIME DP - Unbound Medicine ER -