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Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines.
Neurotoxicology. 2012 Jun; 33(3):482-90.N

Abstract

Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD. The Aβ aggregate-induced neurotoxicity, inflammatory reactions, oxidative stress, and nitric oxide (NO) generation are strongly linked to the etiology of AD. Here, we show that the common dietary flavonoid, rutin, can dose-dependently inhibit Aβ42 fibrillization and attenuate Aβ42-induced cytotoxicity in SH-SY5Y neuroblastoma cells. Moreover, rutin decreases the formation of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), and malondialdehyde (MDA), reduces inducible nitric oxide synthase (iNOS) activity, attenuates mitochondrial damage, increases the glutathione (GSH)/GSSG ratio, enhances the activities of super oxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and modulates the production of proinflammatory cytokines by decreasing TNF-α and IL-1β generation in microglia. Taken together, the actions of rutin on multiple pathogenic factors deserves further investigation for the prevention and treatment of AD.

Authors+Show Affiliations

Tsinghua University School of Medicine, Haidian District, Beijing 100084, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22445961

Citation

Wang, Shao-wei, et al. "Rutin Inhibits Β-amyloid Aggregation and Cytotoxicity, Attenuates Oxidative Stress, and Decreases the Production of Nitric Oxide and Proinflammatory Cytokines." Neurotoxicology, vol. 33, no. 3, 2012, pp. 482-90.
Wang SW, Wang YJ, Su YJ, et al. Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology. 2012;33(3):482-90.
Wang, S. W., Wang, Y. J., Su, Y. J., Zhou, W. W., Yang, S. G., Zhang, R., Zhao, M., Li, Y. N., Zhang, Z. P., Zhan, D. W., & Liu, R. T. (2012). Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology, 33(3), 482-90. https://doi.org/10.1016/j.neuro.2012.03.003
Wang SW, et al. Rutin Inhibits Β-amyloid Aggregation and Cytotoxicity, Attenuates Oxidative Stress, and Decreases the Production of Nitric Oxide and Proinflammatory Cytokines. Neurotoxicology. 2012;33(3):482-90. PubMed PMID: 22445961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. AU - Wang,Shao-wei, AU - Wang,Yu-Jiong, AU - Su,Ya-jing, AU - Zhou,Wei-wei, AU - Yang,Shi-gao, AU - Zhang,Ran, AU - Zhao,Min, AU - Li,Ya-nan, AU - Zhang,Zi-ping, AU - Zhan,Da-wei, AU - Liu,Rui-tian, Y1 - 2012/03/15/ PY - 2011/10/13/received PY - 2012/01/15/revised PY - 2012/03/07/accepted PY - 2012/3/27/entrez PY - 2012/3/27/pubmed PY - 2012/9/19/medline SP - 482 EP - 90 JF - Neurotoxicology JO - Neurotoxicology VL - 33 IS - 3 N2 - Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD. The Aβ aggregate-induced neurotoxicity, inflammatory reactions, oxidative stress, and nitric oxide (NO) generation are strongly linked to the etiology of AD. Here, we show that the common dietary flavonoid, rutin, can dose-dependently inhibit Aβ42 fibrillization and attenuate Aβ42-induced cytotoxicity in SH-SY5Y neuroblastoma cells. Moreover, rutin decreases the formation of reactive oxygen species (ROS), NO, glutathione disulfide (GSSG), and malondialdehyde (MDA), reduces inducible nitric oxide synthase (iNOS) activity, attenuates mitochondrial damage, increases the glutathione (GSH)/GSSG ratio, enhances the activities of super oxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and modulates the production of proinflammatory cytokines by decreasing TNF-α and IL-1β generation in microglia. Taken together, the actions of rutin on multiple pathogenic factors deserves further investigation for the prevention and treatment of AD. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/22445961/Rutin_inhibits_β_amyloid_aggregation_and_cytotoxicity_attenuates_oxidative_stress_and_decreases_the_production_of_nitric_oxide_and_proinflammatory_cytokines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(12)00066-6 DB - PRIME DP - Unbound Medicine ER -