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Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease.
Behav Brain Res 2012; 231(1):154-63BB

Abstract

Animal models are widely used to study alterations caused by Parkinson's disease (PD). However, in general, pharmacological models do not express the progressive nature of the disease, being characterized by immediate severe motor impairment after a single dose of the drug. Reserpine administration in rodents has been suggested as a pharmacological model of PD based on the effects of this monoamine-depleting agent on motor activity. Here, we describe that repeated administration with a low dose (0.1 mg/kg) of reserpine in rats induces a gradual appearance of motor signs, evaluated by catalepsy behavior. Furthermore, these motor signs are accompanied by increased levels of striatal lipid peroxidation. However, treatment with reserpine failed to induce memory impairments (evaluated by novel object recognition and discriminative avoidance tasks) and alterations in hippocampal lipid peroxidation. Thus, repeated treatment with low doses of reserpine progressively induces alterations in motor function and an increase in striatal oxidative stress, indicating a possible application of this model in the study of the neuroprogressive nature of the motor signs in PD.

Authors+Show Affiliations

Memory Studies Laboratory, Physiology Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22446059

Citation

Fernandes, Valéria S., et al. "Repeated Treatment With a Low Dose of Reserpine as a Progressive Model of Parkinson's Disease." Behavioural Brain Research, vol. 231, no. 1, 2012, pp. 154-63.
Fernandes VS, Santos JR, Leão AH, et al. Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease. Behav Brain Res. 2012;231(1):154-63.
Fernandes, V. S., Santos, J. R., Leão, A. H., Medeiros, A. M., Melo, T. G., Izídio, G. S., ... Silva, R. H. (2012). Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease. Behavioural Brain Research, 231(1), pp. 154-63. doi:10.1016/j.bbr.2012.03.008.
Fernandes VS, et al. Repeated Treatment With a Low Dose of Reserpine as a Progressive Model of Parkinson's Disease. Behav Brain Res. 2012 May 16;231(1):154-63. PubMed PMID: 22446059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease. AU - Fernandes,Valéria S, AU - Santos,José R, AU - Leão,Anderson H F F, AU - Medeiros,André M, AU - Melo,Thieza G, AU - Izídio,Geison S, AU - Cabral,Alicia, AU - Ribeiro,Rosana A, AU - Abílio,Vanessa C, AU - Ribeiro,Alessandra M, AU - Silva,Regina H, Y1 - 2012/03/16/ PY - 2012/02/08/received PY - 2012/03/06/revised PY - 2012/03/07/accepted PY - 2012/3/27/entrez PY - 2012/3/27/pubmed PY - 2012/8/21/medline SP - 154 EP - 63 JF - Behavioural brain research JO - Behav. Brain Res. VL - 231 IS - 1 N2 - Animal models are widely used to study alterations caused by Parkinson's disease (PD). However, in general, pharmacological models do not express the progressive nature of the disease, being characterized by immediate severe motor impairment after a single dose of the drug. Reserpine administration in rodents has been suggested as a pharmacological model of PD based on the effects of this monoamine-depleting agent on motor activity. Here, we describe that repeated administration with a low dose (0.1 mg/kg) of reserpine in rats induces a gradual appearance of motor signs, evaluated by catalepsy behavior. Furthermore, these motor signs are accompanied by increased levels of striatal lipid peroxidation. However, treatment with reserpine failed to induce memory impairments (evaluated by novel object recognition and discriminative avoidance tasks) and alterations in hippocampal lipid peroxidation. Thus, repeated treatment with low doses of reserpine progressively induces alterations in motor function and an increase in striatal oxidative stress, indicating a possible application of this model in the study of the neuroprogressive nature of the motor signs in PD. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22446059/Repeated_treatment_with_a_low_dose_of_reserpine_as_a_progressive_model_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00187-8 DB - PRIME DP - Unbound Medicine ER -