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Age at menarche, the leg length to sitting height ratio, and risk of diabetes in middle-aged and elderly Chinese men and women.
PLoS One. 2012; 7(3):e30625.Plos

Abstract

AIMS

To evaluate the associations of age at menarche and the leg length-to-sitting-height ratio, markers of adolescent growth, with risk of diabetes in later life.

MATERIALS AND METHODS

Information from 69,385 women and 55,311 men, aged 40-74 years from the Shanghai Women's Health Study and Shanghai Men's Health Study, were included in the current analyses. Diabetes status was ascertained through biennial in person follow-up. Cox models, with age as the time scale, were used.

RESULTS

There were 2369 cases of diabetes (1831 women; 538 men) during an average of 7.3 and 3.6 years of follow-up of the women and men, respectively. In females, menarche age was inversely associated with diabetes risk after adjustment for birth cohort, education, and income (HR = 0.95, 0.92-0.98). In both genders, leg length-to-sitting-height ratio was inversely related to diabetes (HR = 0.88, 0.80-0.97 for men; HR = 0.91, 0.86-0.96 for women) after adjustment for birth cohort, education, and income. Further adjustment for adult BMI at study enrollment completely eliminated the associations of age at menarche (HR = 0.99, 0.96-1.02) and the leg length-to-sitting-height ratio (HR = 1.00, 0.91-1.10 for men; HR = 1.01, 0.96-1.07 for women) with diabetes risk.

CONCLUSIONS

Our study suggests that markers of an early age at peak height velocity, i.e. early menarche age and low leg-length-to-sitting height ratio, may be associated with diabetes risk later in life and this association is likely to be mediated through obesity.

Authors+Show Affiliations

Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22448212

Citation

Conway, Baqiyyah N., et al. "Age at Menarche, the Leg Length to Sitting Height Ratio, and Risk of Diabetes in Middle-aged and Elderly Chinese Men and Women." PloS One, vol. 7, no. 3, 2012, pp. e30625.
Conway BN, Shu XO, Zhang X, et al. Age at menarche, the leg length to sitting height ratio, and risk of diabetes in middle-aged and elderly Chinese men and women. PLoS ONE. 2012;7(3):e30625.
Conway, B. N., Shu, X. O., Zhang, X., Xiang, Y. B., Cai, H., Li, H., Yang, G., Gao, Y. T., & Zheng, W. (2012). Age at menarche, the leg length to sitting height ratio, and risk of diabetes in middle-aged and elderly Chinese men and women. PloS One, 7(3), e30625. https://doi.org/10.1371/journal.pone.0030625
Conway BN, et al. Age at Menarche, the Leg Length to Sitting Height Ratio, and Risk of Diabetes in Middle-aged and Elderly Chinese Men and Women. PLoS ONE. 2012;7(3):e30625. PubMed PMID: 22448212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age at menarche, the leg length to sitting height ratio, and risk of diabetes in middle-aged and elderly Chinese men and women. AU - Conway,Baqiyyah N, AU - Shu,Xiao-Ou, AU - Zhang,Xianglan, AU - Xiang,Yong-Bing, AU - Cai,Hui, AU - Li,Honglan, AU - Yang,Gong, AU - Gao,Yu-Tang, AU - Zheng,Wei, Y1 - 2012/03/20/ PY - 2011/06/30/received PY - 2011/12/19/accepted PY - 2012/3/27/entrez PY - 2012/3/27/pubmed PY - 2012/8/21/medline SP - e30625 EP - e30625 JF - PloS one JO - PLoS ONE VL - 7 IS - 3 N2 - AIMS: To evaluate the associations of age at menarche and the leg length-to-sitting-height ratio, markers of adolescent growth, with risk of diabetes in later life. MATERIALS AND METHODS: Information from 69,385 women and 55,311 men, aged 40-74 years from the Shanghai Women's Health Study and Shanghai Men's Health Study, were included in the current analyses. Diabetes status was ascertained through biennial in person follow-up. Cox models, with age as the time scale, were used. RESULTS: There were 2369 cases of diabetes (1831 women; 538 men) during an average of 7.3 and 3.6 years of follow-up of the women and men, respectively. In females, menarche age was inversely associated with diabetes risk after adjustment for birth cohort, education, and income (HR = 0.95, 0.92-0.98). In both genders, leg length-to-sitting-height ratio was inversely related to diabetes (HR = 0.88, 0.80-0.97 for men; HR = 0.91, 0.86-0.96 for women) after adjustment for birth cohort, education, and income. Further adjustment for adult BMI at study enrollment completely eliminated the associations of age at menarche (HR = 0.99, 0.96-1.02) and the leg length-to-sitting-height ratio (HR = 1.00, 0.91-1.10 for men; HR = 1.01, 0.96-1.07 for women) with diabetes risk. CONCLUSIONS: Our study suggests that markers of an early age at peak height velocity, i.e. early menarche age and low leg-length-to-sitting height ratio, may be associated with diabetes risk later in life and this association is likely to be mediated through obesity. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22448212/Age_at_menarche_the_leg_length_to_sitting_height_ratio_and_risk_of_diabetes_in_middle_aged_and_elderly_Chinese_men_and_women_ L2 - http://dx.plos.org/10.1371/journal.pone.0030625 DB - PRIME DP - Unbound Medicine ER -