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Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis.
J Cogn Neurosci 2012; 24(8):1682-94JC

Abstract

In a previous oddball task study, it was shown that the inclusion of electrophysiology (EEG), that is, single-trial P3 ERP parameters, in the analysis of fMRI responses can detect activation that is not apparent with conventional fMRI data modeling strategies [Warbrick, T., Mobascher, A., Brinkmeyer, J., Musso, F., Richter, N., Stoecker, T., et al. Single-trial P3 amplitude and latency informed event-related fMRI models yield different BOLD response patterns to a target detection task. Neuroimage, 47, 1532-1544, 2009]. Given that P3 is modulated by nicotine, including P3 parameters in the fMRI analysis might provide additional information about nicotine effects on brain function. A 1-mg nasal nicotine spray (0.5 mg each nostril) or placebo (pepper) spray was administered in a double-blind, placebo-controlled, within-subject, randomized, cross-over design. Simultaneous EEG-fMRI and behavioral data were recorded from 19 current smokers in response to an oddball-type visual choice RT task. Conventional general linear model analysis and single-trial P3 amplitude informed general linear model analysis of the fMRI data were performed. Comparing the nicotine with the placebo condition, reduced RTs in the nicotine condition were related to decreased BOLD responses in the conventional analysis encompassing the superior parietal lobule, the precuneus, and the lateral occipital cortex. On the other hand, reduced RTs were related to increased BOLD responses in the precentral and postcentral gyri, and ACC in the EEG-informed fMRI analysis. Our results show how integrated analyses of simultaneous EEG-fMRI data can be used to detect nicotine effects that would not have been revealed through conventional analysis of either measure in isolation. This emphasizes the significance of applying multimodal imaging methods to pharmacoimaging.

Authors+Show Affiliations

Institute of Neuroscience and Medicine, Research Center Jülich, Leo-Brandt Strasse, 52425 Jülich, Germany. t.warbrick@fzjuelich.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22452559

Citation

Warbrick, Tracy, et al. "Nicotine Effects On Brain Function During a Visual Oddball Task: a Comparison Between Conventional and EEG-informed fMRI Analysis." Journal of Cognitive Neuroscience, vol. 24, no. 8, 2012, pp. 1682-94.
Warbrick T, Mobascher A, Brinkmeyer J, et al. Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis. J Cogn Neurosci. 2012;24(8):1682-94.
Warbrick, T., Mobascher, A., Brinkmeyer, J., Musso, F., Stoecker, T., Shah, N. J., ... Winterer, G. (2012). Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis. Journal of Cognitive Neuroscience, 24(8), pp. 1682-94. doi:10.1162/jocn_a_00236.
Warbrick T, et al. Nicotine Effects On Brain Function During a Visual Oddball Task: a Comparison Between Conventional and EEG-informed fMRI Analysis. J Cogn Neurosci. 2012;24(8):1682-94. PubMed PMID: 22452559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis. AU - Warbrick,Tracy, AU - Mobascher,Arian, AU - Brinkmeyer,Jürgen, AU - Musso,Francesco, AU - Stoecker,Tony, AU - Shah,N Jon, AU - Fink,Gereon R, AU - Winterer,Georg, Y1 - 2012/03/27/ PY - 2012/3/29/entrez PY - 2012/3/29/pubmed PY - 2012/12/10/medline SP - 1682 EP - 94 JF - Journal of cognitive neuroscience JO - J Cogn Neurosci VL - 24 IS - 8 N2 - In a previous oddball task study, it was shown that the inclusion of electrophysiology (EEG), that is, single-trial P3 ERP parameters, in the analysis of fMRI responses can detect activation that is not apparent with conventional fMRI data modeling strategies [Warbrick, T., Mobascher, A., Brinkmeyer, J., Musso, F., Richter, N., Stoecker, T., et al. Single-trial P3 amplitude and latency informed event-related fMRI models yield different BOLD response patterns to a target detection task. Neuroimage, 47, 1532-1544, 2009]. Given that P3 is modulated by nicotine, including P3 parameters in the fMRI analysis might provide additional information about nicotine effects on brain function. A 1-mg nasal nicotine spray (0.5 mg each nostril) or placebo (pepper) spray was administered in a double-blind, placebo-controlled, within-subject, randomized, cross-over design. Simultaneous EEG-fMRI and behavioral data were recorded from 19 current smokers in response to an oddball-type visual choice RT task. Conventional general linear model analysis and single-trial P3 amplitude informed general linear model analysis of the fMRI data were performed. Comparing the nicotine with the placebo condition, reduced RTs in the nicotine condition were related to decreased BOLD responses in the conventional analysis encompassing the superior parietal lobule, the precuneus, and the lateral occipital cortex. On the other hand, reduced RTs were related to increased BOLD responses in the precentral and postcentral gyri, and ACC in the EEG-informed fMRI analysis. Our results show how integrated analyses of simultaneous EEG-fMRI data can be used to detect nicotine effects that would not have been revealed through conventional analysis of either measure in isolation. This emphasizes the significance of applying multimodal imaging methods to pharmacoimaging. SN - 1530-8898 UR - https://www.unboundmedicine.com/medline/citation/22452559/Nicotine_effects_on_brain_function_during_a_visual_oddball_task:_a_comparison_between_conventional_and_EEG_informed_fMRI_analysis_ L2 - http://www.mitpressjournals.org/doi/full/10.1162/jocn_a_00236?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -