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Vitamin D status in children with chronic kidney disease.
Pediatr Nephrol. 2012 Aug; 27(8):1341-50.PN

Abstract

BACKGROUND

The role of vitamin D status in patients with renal insufficiency and its relation to dietary intake and parathyroid hormone (PTH) secretion is of utmost interest given the morbidity and mortality associated with the disordered mineral metabolism seen in chronic kidney disease (CKD).

METHODS

We conducted a cross-sectional study of 100 pediatric patients with a diagnosis of CKD stage 1-5 at Children's Hospital Boston, measuring blood levels of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)(2)D], and parathyroid hormone and obtaining data on nutrient intake and other variables related to vitamin D status.

RESULTS

Subjects ranged in age from 6 months to 18 years, and 60 were male, 40 female. Of the 100 patients, 16 % were deficient in 25(OH)D (≤ 20 ng/mL) and another 24 % were insufficient (≤ 30 ng/mL), with 40 % in the suboptimal range. Serum 25(OH)D and dietary vitamin D intake were not correlated.

CONCLUSIONS

We found a high prevalence of hyperparathyroidism in early-stage CKD and a significant relationship between 25(OH)D and PTH regardless of calcitriol level. Our study results support the suggestion that optimization of vitamin D levels may provide additional benefit in preventing or improving hyperparathyroidism in patients with early CKD and likely remains important as an adjunctive therapy in children with advanced CKD.

Authors+Show Affiliations

Department of Pediatrics, Children's Hospital Boston, Boston, MA, USA. deborah.stein@childrens.harvard.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22453735

Citation

Stein, Deborah R., et al. "Vitamin D Status in Children With Chronic Kidney Disease." Pediatric Nephrology (Berlin, Germany), vol. 27, no. 8, 2012, pp. 1341-50.
Stein DR, Feldman HA, Gordon CM. Vitamin D status in children with chronic kidney disease. Pediatr Nephrol. 2012;27(8):1341-50.
Stein, D. R., Feldman, H. A., & Gordon, C. M. (2012). Vitamin D status in children with chronic kidney disease. Pediatric Nephrology (Berlin, Germany), 27(8), 1341-50. https://doi.org/10.1007/s00467-012-2143-7
Stein DR, Feldman HA, Gordon CM. Vitamin D Status in Children With Chronic Kidney Disease. Pediatr Nephrol. 2012;27(8):1341-50. PubMed PMID: 22453735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status in children with chronic kidney disease. AU - Stein,Deborah R, AU - Feldman,Henry A, AU - Gordon,Catherine M, Y1 - 2012/03/28/ PY - 2011/09/23/received PY - 2012/02/14/accepted PY - 2012/02/09/revised PY - 2012/3/29/entrez PY - 2012/3/29/pubmed PY - 2012/10/31/medline SP - 1341 EP - 50 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 27 IS - 8 N2 - BACKGROUND: The role of vitamin D status in patients with renal insufficiency and its relation to dietary intake and parathyroid hormone (PTH) secretion is of utmost interest given the morbidity and mortality associated with the disordered mineral metabolism seen in chronic kidney disease (CKD). METHODS: We conducted a cross-sectional study of 100 pediatric patients with a diagnosis of CKD stage 1-5 at Children's Hospital Boston, measuring blood levels of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)(2)D], and parathyroid hormone and obtaining data on nutrient intake and other variables related to vitamin D status. RESULTS: Subjects ranged in age from 6 months to 18 years, and 60 were male, 40 female. Of the 100 patients, 16 % were deficient in 25(OH)D (≤ 20 ng/mL) and another 24 % were insufficient (≤ 30 ng/mL), with 40 % in the suboptimal range. Serum 25(OH)D and dietary vitamin D intake were not correlated. CONCLUSIONS: We found a high prevalence of hyperparathyroidism in early-stage CKD and a significant relationship between 25(OH)D and PTH regardless of calcitriol level. Our study results support the suggestion that optimization of vitamin D levels may provide additional benefit in preventing or improving hyperparathyroidism in patients with early CKD and likely remains important as an adjunctive therapy in children with advanced CKD. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/22453735/Vitamin_D_status_in_children_with_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s00467-012-2143-7 DB - PRIME DP - Unbound Medicine ER -