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Store-operated Ca(2+) entry.
Adv Exp Med Biol. 2012; 740:349-82.AE

Abstract

Store-operated Ca(2+) entry (SOCE) is an ubiquitous and major mechanism for Ca(2+) influx in mammalian cells with important physiological relevance. Since the discovery of SOCE in 1986 both, the mechanism that communicates the amount of Ca(2+) accumulated in the intracellular Ca(2+) stores to the plasma membrane channels and the nature of the capacitative channels, have been a matter of intense investigation. During the last decade, two of the major elements of SOCE, STIM1, the Ca(2+) sensor of the intracellular Ca(2+) compartments, and Orai1, the protein forming the channel that conducts the capacitative Ca(2+) release-activated current I (CRAC), were identified. Together with these proteins, different homologues, including STIM2, Orai2 and Orai3, were identified, although their relevance in SOCE has not been fully characterized yet. Before the identification of STIM1 and Orai1, TRPC proteins were found to be involved in SOCE in different cell types, more likely conducting the non-selective capacitative current described as I (SOC). Current evidence indicates that STIM1, Orai1 and TRPC proteins dynamically interact forming a ternary complex that mediates SOCE in a number of cellular models. The dynamic interaction of STIM1 with Orai1, TRPCs or both might provide an explanation to the distinct capacitative currents described in different cell types.

Authors+Show Affiliations

Department of Physiology, Cell Physiology Research Group, University of Extremadura, Cáceres 10003, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22453950

Citation

Berna-Erro, Alejandro, et al. "Store-operated Ca(2+) Entry." Advances in Experimental Medicine and Biology, vol. 740, 2012, pp. 349-82.
Berna-Erro A, Redondo PC, Rosado JA. Store-operated Ca(2+) entry. Adv Exp Med Biol. 2012;740:349-82.
Berna-Erro, A., Redondo, P. C., & Rosado, J. A. (2012). Store-operated Ca(2+) entry. Advances in Experimental Medicine and Biology, 740, 349-82. https://doi.org/10.1007/978-94-007-2888-2_15
Berna-Erro A, Redondo PC, Rosado JA. Store-operated Ca(2+) Entry. Adv Exp Med Biol. 2012;740:349-82. PubMed PMID: 22453950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Store-operated Ca(2+) entry. AU - Berna-Erro,Alejandro, AU - Redondo,Pedro C, AU - Rosado,Juan A, PY - 2012/3/29/entrez PY - 2012/3/29/pubmed PY - 2012/9/19/medline SP - 349 EP - 82 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 740 N2 - Store-operated Ca(2+) entry (SOCE) is an ubiquitous and major mechanism for Ca(2+) influx in mammalian cells with important physiological relevance. Since the discovery of SOCE in 1986 both, the mechanism that communicates the amount of Ca(2+) accumulated in the intracellular Ca(2+) stores to the plasma membrane channels and the nature of the capacitative channels, have been a matter of intense investigation. During the last decade, two of the major elements of SOCE, STIM1, the Ca(2+) sensor of the intracellular Ca(2+) compartments, and Orai1, the protein forming the channel that conducts the capacitative Ca(2+) release-activated current I (CRAC), were identified. Together with these proteins, different homologues, including STIM2, Orai2 and Orai3, were identified, although their relevance in SOCE has not been fully characterized yet. Before the identification of STIM1 and Orai1, TRPC proteins were found to be involved in SOCE in different cell types, more likely conducting the non-selective capacitative current described as I (SOC). Current evidence indicates that STIM1, Orai1 and TRPC proteins dynamically interact forming a ternary complex that mediates SOCE in a number of cellular models. The dynamic interaction of STIM1 with Orai1, TRPCs or both might provide an explanation to the distinct capacitative currents described in different cell types. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/22453950/Store_operated_Ca_2+__entry_ L2 - https://dx.doi.org/10.1007/978-94-007-2888-2_15 DB - PRIME DP - Unbound Medicine ER -