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Structure, regulation and biophysics of I(CRAC), STIM/Orai1.
Adv Exp Med Biol. 2012; 740:383-410.AE

Abstract

Ca(2+) release activated Ca(2+) (CRAC) channels mediate robust Ca(2+) influx when the endoplasmic reticulum Ca(2+) stores are depleted. This essential process for T-cell activation as well as degranulation of mast cells involves the Ca(2+) sensor STIM1, located in the endoplasmic reticulum and the Ca(2+) selective Orai1 channel in the plasma membrane. Our review describes the CRAC signaling pathway, the activation of which is initiated by a drop in the endoplasmic Ca(2+) level sensed by STIM1. This in term induces multimerisation and puncta-formation of STIM1 proteins is followed by their coupling to and activation of Orai channels. Consequently Ca(2+) entry is triggered through the Orai pore into the cytosol with subsequent closure of the channel by Ca(2+)-dependent inactivation. We will portray a mechanistic view of the events coupling STIM1 to Orai activation based on their structure and biophysics.

Authors+Show Affiliations

Institute of Biophysics, University of Linz, Austria. isabella.derler@jku.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22453951

Citation

Derler, Isabella, et al. "Structure, Regulation and Biophysics of I(CRAC), STIM/Orai1." Advances in Experimental Medicine and Biology, vol. 740, 2012, pp. 383-410.
Derler I, Madl J, Schütz G, et al. Structure, regulation and biophysics of I(CRAC), STIM/Orai1. Adv Exp Med Biol. 2012;740:383-410.
Derler, I., Madl, J., Schütz, G., & Romanin, C. (2012). Structure, regulation and biophysics of I(CRAC), STIM/Orai1. Advances in Experimental Medicine and Biology, 740, 383-410. https://doi.org/10.1007/978-94-007-2888-2_16
Derler I, et al. Structure, Regulation and Biophysics of I(CRAC), STIM/Orai1. Adv Exp Med Biol. 2012;740:383-410. PubMed PMID: 22453951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structure, regulation and biophysics of I(CRAC), STIM/Orai1. AU - Derler,Isabella, AU - Madl,Josef, AU - Schütz,Gerhard, AU - Romanin,Christoph, PY - 2012/3/29/entrez PY - 2012/3/29/pubmed PY - 2012/9/19/medline SP - 383 EP - 410 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 740 N2 - Ca(2+) release activated Ca(2+) (CRAC) channels mediate robust Ca(2+) influx when the endoplasmic reticulum Ca(2+) stores are depleted. This essential process for T-cell activation as well as degranulation of mast cells involves the Ca(2+) sensor STIM1, located in the endoplasmic reticulum and the Ca(2+) selective Orai1 channel in the plasma membrane. Our review describes the CRAC signaling pathway, the activation of which is initiated by a drop in the endoplasmic Ca(2+) level sensed by STIM1. This in term induces multimerisation and puncta-formation of STIM1 proteins is followed by their coupling to and activation of Orai channels. Consequently Ca(2+) entry is triggered through the Orai pore into the cytosol with subsequent closure of the channel by Ca(2+)-dependent inactivation. We will portray a mechanistic view of the events coupling STIM1 to Orai activation based on their structure and biophysics. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/22453951/Structure_regulation_and_biophysics_of_I_CRAC__STIM/Orai1_ L2 - https://dx.doi.org/10.1007/978-94-007-2888-2_16 DB - PRIME DP - Unbound Medicine ER -