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Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women.
J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1092-8.JG

Abstract

BACKGROUND

Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.

METHODS

The study is a cross-sectional and longitudinal analysis of a prospective cohort of 6,257 community-dwelling elderly women followed for 4 years. Global cognitive function was measured by the Modified Mini-Mental State Examination and executive function was measured by Trail Making Test Part B (Trails B). Cognitive impairment at baseline was defined as a score >1.5 SD below the sample mean; cognitive decline was defined as decline from baseline to follow-up >1 SD from mean change in score.

RESULTS

Women with very low vitamin D levels had an increased odds of global cognitive impairment at baseline: odds ratio (95% confidence interval), 1.60 (1.05-2.42) for women with 25(OH)D <10 ng/mL (25 nmol/L) compared with those with 25(OH)D levels ≥30 ng/mL (75 nmol/L). Compared with women with baseline 25(OH)D level ≥30 ng/mL (75 nmol/L), women with lower levels had an increased risk of global cognitive decline: odds ratio (95% confidence interval), 1.58(1.12-2.22) for women with levels <10 ng/mL (25 nmol/L), and 1.31 (1.04-1.64) for those with levels 10-19.9 ng/mL (25-49 nmol/L). Levels of 25(OH)D were not associated with executive cognitive function.

CONCLUSIONS

Low 25(OH)D levels among older women were associated with a higher odds of global cognitive impairment and a higher risk of global cognitive decline.

Authors+Show Affiliations

Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota, USA. slini001@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22454371

Citation

Slinin, Yelena, et al. "Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older Women." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 67, no. 10, 2012, pp. 1092-8.
Slinin Y, Paudel M, Taylor BC, et al. Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. J Gerontol A Biol Sci Med Sci. 2012;67(10):1092-8.
Slinin, Y., Paudel, M., Taylor, B. C., Ishani, A., Rossom, R., Yaffe, K., Blackwell, T., Lui, L. Y., Hochberg, M., & Ensrud, K. E. (2012). Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 67(10), 1092-8.
Slinin Y, et al. Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older Women. J Gerontol A Biol Sci Med Sci. 2012;67(10):1092-8. PubMed PMID: 22454371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. AU - Slinin,Yelena, AU - Paudel,Misti, AU - Taylor,Brent C, AU - Ishani,Areef, AU - Rossom,Rebecca, AU - Yaffe,Kristine, AU - Blackwell,Terri, AU - Lui,Li-Yung, AU - Hochberg,Marc, AU - Ensrud,Kristine E, AU - ,, Y1 - 2012/03/27/ PY - 2012/3/29/entrez PY - 2012/3/29/pubmed PY - 2012/11/14/medline SP - 1092 EP - 8 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. VL - 67 IS - 10 N2 - BACKGROUND: Results of prospective studies examining the association between 25 hydroxyvitamin D (25[OH]D) levels and cognitive decline have been inconsistent. We tested the hypothesis that lower 25(OH)D levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. METHODS: The study is a cross-sectional and longitudinal analysis of a prospective cohort of 6,257 community-dwelling elderly women followed for 4 years. Global cognitive function was measured by the Modified Mini-Mental State Examination and executive function was measured by Trail Making Test Part B (Trails B). Cognitive impairment at baseline was defined as a score >1.5 SD below the sample mean; cognitive decline was defined as decline from baseline to follow-up >1 SD from mean change in score. RESULTS: Women with very low vitamin D levels had an increased odds of global cognitive impairment at baseline: odds ratio (95% confidence interval), 1.60 (1.05-2.42) for women with 25(OH)D <10 ng/mL (25 nmol/L) compared with those with 25(OH)D levels ≥30 ng/mL (75 nmol/L). Compared with women with baseline 25(OH)D level ≥30 ng/mL (75 nmol/L), women with lower levels had an increased risk of global cognitive decline: odds ratio (95% confidence interval), 1.58(1.12-2.22) for women with levels <10 ng/mL (25 nmol/L), and 1.31 (1.04-1.64) for those with levels 10-19.9 ng/mL (25-49 nmol/L). Levels of 25(OH)D were not associated with executive cognitive function. CONCLUSIONS: Low 25(OH)D levels among older women were associated with a higher odds of global cognitive impairment and a higher risk of global cognitive decline. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/22454371/Association_between_serum_25_OH__vitamin_D_and_the_risk_of_cognitive_decline_in_older_women_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/gls075 DB - PRIME DP - Unbound Medicine ER -