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[Effects of a low-fat and high-carbohydrate diet on the physiological and biochemical indices in healthy youth with different body mass index].

Abstract

OBJECTIVE

To investigate the effects of a low-fat and high-carbohydrate (LF-HC) diet on the physiological and biochemical indexes in healthy youth with different body mass index (BMI).

METHODS

Seven overweight participants [BMI=(27.82 +/- 1.64) kg/m2] and 49 age-matched controls [BMI = (20.06 +/- 2.41) kg/ m2] were given a washout diet for 7 d, followed by a LF-HC diet for 6 d. The washout diet contained 31.1% fat and 54.1% carbohydrate, and the LF-HC diet contained 14.8% fat and 70.1% carbohydrate of total energy. Anthropometric measurements were conducted on the mornings of the first, eighth and fourteenth days. Serum samples were prepared from twelve-hour fasting venous blood. Biochemical indexes including lipids; glucose and insulin were measured with routine methods. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated.

RESULTS

At baseline, the control group had lower levels of body mass (P = 0.000), BMI (P = 0.000), waist-hip ratio (P = 0.000), systolic blood pressure (P = 0.001), diagnostic blood pressure (P = 0.016) and triglycerides (P = 0.006), and a higher level of HDL cholesterol (P = 0.005) than the overweight group. When compared with those before the ILF-HC diet, total cholesterol (P < 0.05) and LDL cholesterol (P < 0.05) decreased, and insulin (P < 0.05) and HOMA-IR (P < 0.05) increased in both the control group and the overweight group after the LF-HC diet. Increased triglycerides (P = 0.000) were observed only in the control subjects, and HDL cholesterol (P = 0.018) increased only in the overweight subjects after the LF-HC diet.

CONCLUSION

The responses of serum TG and HDL-C to the LF-HC diet are related to BMI in healthy youth.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22455122

Citation

Song, Yong-Yan, et al. "[Effects of a Low-fat and High-carbohydrate Diet On the Physiological and Biochemical Indices in Healthy Youth With Different Body Mass Index]." Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, vol. 43, no. 1, 2012, pp. 9-14.
Song YY, Gong RR, Zhang RR, et al. [Effects of a low-fat and high-carbohydrate diet on the physiological and biochemical indices in healthy youth with different body mass index]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012;43(1):9-14.
Song, Y. Y., Gong, R. R., Zhang, R. R., Zhang, Z., Li, Y. H., Hu, M. S., ... Fang, D. Z. (2012). [Effects of a low-fat and high-carbohydrate diet on the physiological and biochemical indices in healthy youth with different body mass index]. Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, 43(1), pp. 9-14.
Song YY, et al. [Effects of a Low-fat and High-carbohydrate Diet On the Physiological and Biochemical Indices in Healthy Youth With Different Body Mass Index]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012;43(1):9-14. PubMed PMID: 22455122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of a low-fat and high-carbohydrate diet on the physiological and biochemical indices in healthy youth with different body mass index]. AU - Song,Yong-Yan, AU - Gong,Ren-Rong, AU - Zhang,Rong-Rong, AU - Zhang,Zhen, AU - Li,Yuan-Hao, AU - Hu,Min-Shan, AU - Li,Rong-Hui, AU - Fang,Ding-Zhi, PY - 2012/3/30/entrez PY - 2012/3/30/pubmed PY - 2012/8/7/medline SP - 9 EP - 14 JF - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition JO - Sichuan Da Xue Xue Bao Yi Xue Ban VL - 43 IS - 1 N2 - OBJECTIVE: To investigate the effects of a low-fat and high-carbohydrate (LF-HC) diet on the physiological and biochemical indexes in healthy youth with different body mass index (BMI). METHODS: Seven overweight participants [BMI=(27.82 +/- 1.64) kg/m2] and 49 age-matched controls [BMI = (20.06 +/- 2.41) kg/ m2] were given a washout diet for 7 d, followed by a LF-HC diet for 6 d. The washout diet contained 31.1% fat and 54.1% carbohydrate, and the LF-HC diet contained 14.8% fat and 70.1% carbohydrate of total energy. Anthropometric measurements were conducted on the mornings of the first, eighth and fourteenth days. Serum samples were prepared from twelve-hour fasting venous blood. Biochemical indexes including lipids; glucose and insulin were measured with routine methods. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: At baseline, the control group had lower levels of body mass (P = 0.000), BMI (P = 0.000), waist-hip ratio (P = 0.000), systolic blood pressure (P = 0.001), diagnostic blood pressure (P = 0.016) and triglycerides (P = 0.006), and a higher level of HDL cholesterol (P = 0.005) than the overweight group. When compared with those before the ILF-HC diet, total cholesterol (P < 0.05) and LDL cholesterol (P < 0.05) decreased, and insulin (P < 0.05) and HOMA-IR (P < 0.05) increased in both the control group and the overweight group after the LF-HC diet. Increased triglycerides (P = 0.000) were observed only in the control subjects, and HDL cholesterol (P = 0.018) increased only in the overweight subjects after the LF-HC diet. CONCLUSION: The responses of serum TG and HDL-C to the LF-HC diet are related to BMI in healthy youth. SN - 1672-173X UR - https://www.unboundmedicine.com/medline/citation/22455122/[Effects_of_a_low_fat_and_high_carbohydrate_diet_on_the_physiological_and_biochemical_indices_in_healthy_youth_with_different_body_mass_index]_ L2 - https://medlineplus.gov/dietaryfats.html DB - PRIME DP - Unbound Medicine ER -