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Coffee, tea, soda, and caffeine intake in relation to risk of adult glioma in the NIH-AARP Diet and Health Study.
Cancer Causes Control 2012; 23(5):757-68CC

Abstract

PURPOSE

We utilized the large, prospective NIH-AARP Diet and Health Study to further explore the hypothesis, suggested by two recent prospective cohort studies, that increased intake of coffee, tea, soda, and/or caffeine is associated with reduced adult glioma risk.

METHODS

At baseline in 1995-1996, dietary intake, including coffee, tea, and soda, was assessed with a food frequency questionnaire. We used Cox proportional hazards models to calculate adjusted hazard ratios (HR) and 95 % confidence intervals (CI) for glioma risk in relation to beverage intake.

RESULTS

During follow-up of 545,771 participants through 2006, 904 participants were diagnosed with glioma. We found no trends of decreasing glioma risk with increasing intake of specific beverages or total caffeine. HR patterns for consumption of the caffeinated versus decaffeinated form of each beverage were inconsistent with a specific caffeine effect. HR patterns of reduced glioma risk for most categories of beverage intake greater than "none" prompted a post hoc analysis that revealed borderline-significant inverse associations for any versus no intake of tea (HR = 0.84; 95 % CI, 0.69-1.03), total coffee plus tea (HR = 0.70; 95 % CI, 0.48-1.03), and soda (HR = 0.82; 95 % CI, 0.67-1.01).

CONCLUSIONS

The borderline-significant inverse associations could be explained by a threshold effect in which any beverage intake above a low level confers a beneficial effect, most likely due to beverage constituents other than caffeine. They could also be explained by non-drinkers of these beverages sharing unknown extraneous characteristics associated with increased glioma risk, or by chance.

Authors+Show Affiliations

Yale School of Public Health, Yale School of Medicine, New Haven, CT, USA. robert.dubrow@yale.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

22457000

Citation

Dubrow, Robert, et al. "Coffee, Tea, Soda, and Caffeine Intake in Relation to Risk of Adult Glioma in the NIH-AARP Diet and Health Study." Cancer Causes & Control : CCC, vol. 23, no. 5, 2012, pp. 757-68.
Dubrow R, Darefsky AS, Freedman ND, et al. Coffee, tea, soda, and caffeine intake in relation to risk of adult glioma in the NIH-AARP Diet and Health Study. Cancer Causes Control. 2012;23(5):757-68.
Dubrow, R., Darefsky, A. S., Freedman, N. D., Hollenbeck, A. R., & Sinha, R. (2012). Coffee, tea, soda, and caffeine intake in relation to risk of adult glioma in the NIH-AARP Diet and Health Study. Cancer Causes & Control : CCC, 23(5), pp. 757-68. doi:10.1007/s10552-012-9945-6.
Dubrow R, et al. Coffee, Tea, Soda, and Caffeine Intake in Relation to Risk of Adult Glioma in the NIH-AARP Diet and Health Study. Cancer Causes Control. 2012;23(5):757-68. PubMed PMID: 22457000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee, tea, soda, and caffeine intake in relation to risk of adult glioma in the NIH-AARP Diet and Health Study. AU - Dubrow,Robert, AU - Darefsky,Amy S, AU - Freedman,Neal D, AU - Hollenbeck,Albert R, AU - Sinha,Rashmi, Y1 - 2012/03/29/ PY - 2011/10/19/received PY - 2012/03/14/accepted PY - 2012/3/30/entrez PY - 2012/3/30/pubmed PY - 2012/10/23/medline SP - 757 EP - 68 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 23 IS - 5 N2 - PURPOSE: We utilized the large, prospective NIH-AARP Diet and Health Study to further explore the hypothesis, suggested by two recent prospective cohort studies, that increased intake of coffee, tea, soda, and/or caffeine is associated with reduced adult glioma risk. METHODS: At baseline in 1995-1996, dietary intake, including coffee, tea, and soda, was assessed with a food frequency questionnaire. We used Cox proportional hazards models to calculate adjusted hazard ratios (HR) and 95 % confidence intervals (CI) for glioma risk in relation to beverage intake. RESULTS: During follow-up of 545,771 participants through 2006, 904 participants were diagnosed with glioma. We found no trends of decreasing glioma risk with increasing intake of specific beverages or total caffeine. HR patterns for consumption of the caffeinated versus decaffeinated form of each beverage were inconsistent with a specific caffeine effect. HR patterns of reduced glioma risk for most categories of beverage intake greater than "none" prompted a post hoc analysis that revealed borderline-significant inverse associations for any versus no intake of tea (HR = 0.84; 95 % CI, 0.69-1.03), total coffee plus tea (HR = 0.70; 95 % CI, 0.48-1.03), and soda (HR = 0.82; 95 % CI, 0.67-1.01). CONCLUSIONS: The borderline-significant inverse associations could be explained by a threshold effect in which any beverage intake above a low level confers a beneficial effect, most likely due to beverage constituents other than caffeine. They could also be explained by non-drinkers of these beverages sharing unknown extraneous characteristics associated with increased glioma risk, or by chance. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/22457000/Coffee_tea_soda_and_caffeine_intake_in_relation_to_risk_of_adult_glioma_in_the_NIH_AARP_Diet_and_Health_Study_ L2 - https://doi.org/10.1007/s10552-012-9945-6 DB - PRIME DP - Unbound Medicine ER -