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Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 07; 38(2):168-74.PN

Abstract

Bipolar disorder (BD) is a common and severe mood disorder associated with higher rates of suicide and disability. Ouabain, a Na(+)/K(+)-ATPase inhibitor, induces behavioral changes in rats and has been used as a model of mania. The aim of this study was to investigate if diphenyl diselenide [(PhSe)(2)], an organoselenium compound with pharmacological properties, is effective against ouabain-induced hyperactivity and alterations in cerebral oxidative status of rats. Male Wistar rats were treated with a single dose of (PhSe)(2) (50 mg/kg, p.o.) 30 min before i.c.v. injection of ouabain (5 μl, 10(-5) M) or with the mood stabilizer, lithium chloride (LiCl) (45 mg/kg, p.o.), twice a day, for 7 days before the administration of ouabain. Open-field locomotion was quantified after ouabain administration. Thiobarbituric acid reactive substances (TBARS), oxidatively modified proteins, tyrosine nitration, ascorbic acid and non-protein thiols (NPSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined in the whole brain. Ouabain increased locomotor activity in the open-field test and pretreatment with (PhSe)(2) or LiCl blocked this effect. In addition, ouabain increased lipid peroxidation and oxidatively modified proteins, demonstrated by a significant increase in TBARS levels and carbonyl content, which were attenuated by pretreatment with (PhSe)(2) or LiCl. The activities of SOD and CAT were increased by ouabain. LiCl was effective on preventing the increases of both enzyme activities, but (PhSe)(2) attenuated the ouabain effect in SOD activity. GPx and GR activities, ascorbic acid, NPSH and tyrosine nitration levels were not altered in all experimental groups. Similarly to LiCl, (PhSe)(2) produced an antimanic-like action, since it was effective against the locomotor hyperactivity elicited by ouabain. The results also indicated that (PhSe)(2) was effective against oxidative stress caused by ouabain in rats.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22459096

Citation

Brüning, César Augusto, et al. "Diphenyl Diselenide Ameliorates Behavioral and Oxidative Parameters in an Animal Model of Mania Induced By Ouabain." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 38, no. 2, 2012, pp. 168-74.
Brüning CA, Prigol M, Luchese C, et al. Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38(2):168-74.
Brüning, C. A., Prigol, M., Luchese, C., Pinton, S., & Nogueira, C. W. (2012). Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain. Progress in Neuro-psychopharmacology & Biological Psychiatry, 38(2), 168-74. https://doi.org/10.1016/j.pnpbp.2012.03.005
Brüning CA, et al. Diphenyl Diselenide Ameliorates Behavioral and Oxidative Parameters in an Animal Model of Mania Induced By Ouabain. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):168-74. PubMed PMID: 22459096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain. AU - Brüning,César Augusto, AU - Prigol,Marina, AU - Luchese,Cristiane, AU - Pinton,Simone, AU - Nogueira,Cristina Wayne, Y1 - 2012/03/20/ PY - 2011/11/11/received PY - 2012/03/09/revised PY - 2012/03/09/accepted PY - 2012/3/31/entrez PY - 2012/3/31/pubmed PY - 2013/1/23/medline SP - 168 EP - 74 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 38 IS - 2 N2 - Bipolar disorder (BD) is a common and severe mood disorder associated with higher rates of suicide and disability. Ouabain, a Na(+)/K(+)-ATPase inhibitor, induces behavioral changes in rats and has been used as a model of mania. The aim of this study was to investigate if diphenyl diselenide [(PhSe)(2)], an organoselenium compound with pharmacological properties, is effective against ouabain-induced hyperactivity and alterations in cerebral oxidative status of rats. Male Wistar rats were treated with a single dose of (PhSe)(2) (50 mg/kg, p.o.) 30 min before i.c.v. injection of ouabain (5 μl, 10(-5) M) or with the mood stabilizer, lithium chloride (LiCl) (45 mg/kg, p.o.), twice a day, for 7 days before the administration of ouabain. Open-field locomotion was quantified after ouabain administration. Thiobarbituric acid reactive substances (TBARS), oxidatively modified proteins, tyrosine nitration, ascorbic acid and non-protein thiols (NPSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined in the whole brain. Ouabain increased locomotor activity in the open-field test and pretreatment with (PhSe)(2) or LiCl blocked this effect. In addition, ouabain increased lipid peroxidation and oxidatively modified proteins, demonstrated by a significant increase in TBARS levels and carbonyl content, which were attenuated by pretreatment with (PhSe)(2) or LiCl. The activities of SOD and CAT were increased by ouabain. LiCl was effective on preventing the increases of both enzyme activities, but (PhSe)(2) attenuated the ouabain effect in SOD activity. GPx and GR activities, ascorbic acid, NPSH and tyrosine nitration levels were not altered in all experimental groups. Similarly to LiCl, (PhSe)(2) produced an antimanic-like action, since it was effective against the locomotor hyperactivity elicited by ouabain. The results also indicated that (PhSe)(2) was effective against oxidative stress caused by ouabain in rats. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/22459096/Diphenyl_diselenide_ameliorates_behavioral_and_oxidative_parameters_in_an_animal_model_of_mania_induced_by_ouabain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(12)00051-6 DB - PRIME DP - Unbound Medicine ER -