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Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance.
Clin Hemorheol Microcirc. 2012; 52(1):49-56.CH

Abstract

The association between morbid obesity and hyperhomocysteinemia (HH) remains controversial and the nature of this relationship needs to be clarified as several metabolic, lipidic, inflammatory and anthropometric alterations that accompany morbid obesity may be involved. In 66 morbidly obese patients, 47 women and 19 men aged 41 ± 12 years and 66 normo-weight subjects, 43 women and 23 men, aged 45 ± 11 years, we determined homocysteine (Hcy) levels along with lipidic, anthropometric, inflammatory and insulin resistance markers. In addition, we investigated the effect of Metabolic Syndrome (MS) and its components on Hcy levels. Obese patients had statistically higher Hcy levels than controls: 12.76 ± 5.30 μM vs. 10.67 ± 2.50 μM; p = 0.006. Moreover, morbidly obese subjects showed higher waist circumference, glucose, insulin, HOMA, leptin, triglycerides, fibrinogen, C reactive protein (CRP) (p < 0.001, respectively), and lower vitamin B12 (p = 0.002), folic acid and HDL-cholesterol (p < 0.001, respectively). In the multivariate regression analysis, waist circumference, glucose, leptin and folic acid levels were independent predictors for Hcy values (p < 0.050). When obese patients were classified as having MS or not, no differences in Hcy levels were found between the two groups (p = 0.752). Yet when we analysed separately each MS component, only abdominal obesity was associated with Hcy levels (p = 0.031). Moreover when considering glucose >110 mg/dL (NCEP-ATPIII criteria) instead of glucose intolerance >100 mg/dl (updated ATPIII criteria), it also was associated with HH (p = 0.042). These results were confirmed in the logistic regression analysis where abdominal obesity and glucose >115 mg/dL constitute independent predictors for HH (OR = 3.2; CI: 1.23-13.2; p = 0.032, OR: 4.6; CI: 1.7-22.2; p = 0.016, respectively). The results of our study indicate that increased Hcy levels are related mostly with abdominal obesity and with insulin resistance. Thus, HH may raise atherothrombotic and thromboembolic risk in these patients.

Authors+Show Affiliations

Hemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22460264

Citation

Vayá, Amparo, et al. "Homocysteine Levels in Morbidly Obese Patients: Its Association With Waist Circumference and Insulin Resistance." Clinical Hemorheology and Microcirculation, vol. 52, no. 1, 2012, pp. 49-56.
Vayá A, Rivera L, Hernández-Mijares A, et al. Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance. Clin Hemorheol Microcirc. 2012;52(1):49-56.
Vayá, A., Rivera, L., Hernández-Mijares, A., de la Fuente, M., Solá, E., Romagnoli, M., Alis, R., & Laiz, B. (2012). Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance. Clinical Hemorheology and Microcirculation, 52(1), 49-56. https://doi.org/10.3233/CH-2012-1544
Vayá A, et al. Homocysteine Levels in Morbidly Obese Patients: Its Association With Waist Circumference and Insulin Resistance. Clin Hemorheol Microcirc. 2012;52(1):49-56. PubMed PMID: 22460264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance. AU - Vayá,Amparo, AU - Rivera,Leonor, AU - Hernández-Mijares,Antonio, AU - de la Fuente,Miguel, AU - Solá,Eva, AU - Romagnoli,Marco, AU - Alis,R, AU - Laiz,Begoña, PY - 2012/3/31/entrez PY - 2012/3/31/pubmed PY - 2013/1/8/medline SP - 49 EP - 56 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 52 IS - 1 N2 - The association between morbid obesity and hyperhomocysteinemia (HH) remains controversial and the nature of this relationship needs to be clarified as several metabolic, lipidic, inflammatory and anthropometric alterations that accompany morbid obesity may be involved. In 66 morbidly obese patients, 47 women and 19 men aged 41 ± 12 years and 66 normo-weight subjects, 43 women and 23 men, aged 45 ± 11 years, we determined homocysteine (Hcy) levels along with lipidic, anthropometric, inflammatory and insulin resistance markers. In addition, we investigated the effect of Metabolic Syndrome (MS) and its components on Hcy levels. Obese patients had statistically higher Hcy levels than controls: 12.76 ± 5.30 μM vs. 10.67 ± 2.50 μM; p = 0.006. Moreover, morbidly obese subjects showed higher waist circumference, glucose, insulin, HOMA, leptin, triglycerides, fibrinogen, C reactive protein (CRP) (p < 0.001, respectively), and lower vitamin B12 (p = 0.002), folic acid and HDL-cholesterol (p < 0.001, respectively). In the multivariate regression analysis, waist circumference, glucose, leptin and folic acid levels were independent predictors for Hcy values (p < 0.050). When obese patients were classified as having MS or not, no differences in Hcy levels were found between the two groups (p = 0.752). Yet when we analysed separately each MS component, only abdominal obesity was associated with Hcy levels (p = 0.031). Moreover when considering glucose >110 mg/dL (NCEP-ATPIII criteria) instead of glucose intolerance >100 mg/dl (updated ATPIII criteria), it also was associated with HH (p = 0.042). These results were confirmed in the logistic regression analysis where abdominal obesity and glucose >115 mg/dL constitute independent predictors for HH (OR = 3.2; CI: 1.23-13.2; p = 0.032, OR: 4.6; CI: 1.7-22.2; p = 0.016, respectively). The results of our study indicate that increased Hcy levels are related mostly with abdominal obesity and with insulin resistance. Thus, HH may raise atherothrombotic and thromboembolic risk in these patients. SN - 1875-8622 UR - https://www.unboundmedicine.com/medline/citation/22460264/Homocysteine_levels_in_morbidly_obese_patients:_its_association_with_waist_circumference_and_insulin_resistance_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/CH-2012-1544 DB - PRIME DP - Unbound Medicine ER -