Tags

Type your tag names separated by a space and hit enter

Altered temporal characteristics of the rectoanal inhibitory reflex in patients with abdominal distension.
Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1343-6.AJ

Abstract

The rectoanal inhibitory reflex (RAIR) is important in gas and stool evacuation. We examined RAIR features in patients with chronic constipation who exhibited bloating with and without abdominal distension, to determine whether alterations in RAIR may be a factor in the pathogenesis of abdominal distension. Seventy-five female patients with chronic constipation with or without abdominal distension were included in the study. The presence or absence of abdominal distension was assessed according to the Rome II questionnaire. All patients underwent both RAIR and rectal sensitivity testing, and specific RAIR parameters were analyzed. Patients were divided into two groups: abdominal bloating with distension (D, n = 55) and abdominal bloating without distension (ND, n = 20). D had a longer time to the onset of anal sphincter inhibition (latency of inhibition) (P = 0.03) compared with ND. In logistic regression analysis, a combination of age, latency of inhibition and the time measured from onset of inhibition to the point of maximum inhibition predicted abdominal distension (P = 0.002). There were no differences between groups for the time from point of maximum inhibition to recovery and for the percentage of internal anal sphincter relaxation. This is the first study to examine the role of RAIR in patients with abdominal distension. Female patients with constipation and abdominal distension exhibited differences in the temporal characteristics of, but not in the degree of, anal sphincter relaxation compared with patients without distension. Since this study was uncontrolled, further studies are necessary to determine the contribution of altered anorectal reflexes to abdominal distension.

Authors+Show Affiliations

Gastrointestinal Investigation Unit, Royal North Shore Hospital and University of Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22461025

Citation

Shim, L, et al. "Altered Temporal Characteristics of the Rectoanal Inhibitory Reflex in Patients With Abdominal Distension." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 302, no. 11, 2012, pp. G1343-6.
Shim L, Hansen RD, Prott GM, et al. Altered temporal characteristics of the rectoanal inhibitory reflex in patients with abdominal distension. Am J Physiol Gastrointest Liver Physiol. 2012;302(11):G1343-6.
Shim, L., Hansen, R. D., Prott, G. M., Morris, L. A., Malcolm, A., & Kellow, J. E. (2012). Altered temporal characteristics of the rectoanal inhibitory reflex in patients with abdominal distension. American Journal of Physiology. Gastrointestinal and Liver Physiology, 302(11), G1343-6. https://doi.org/10.1152/ajpgi.00400.2011
Shim L, et al. Altered Temporal Characteristics of the Rectoanal Inhibitory Reflex in Patients With Abdominal Distension. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1343-6. PubMed PMID: 22461025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered temporal characteristics of the rectoanal inhibitory reflex in patients with abdominal distension. AU - Shim,L, AU - Hansen,R D, AU - Prott,G M, AU - Morris,L A I, AU - Malcolm,A, AU - Kellow,J E, Y1 - 2012/03/29/ PY - 2012/3/31/entrez PY - 2012/3/31/pubmed PY - 2012/8/11/medline SP - G1343 EP - 6 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am. J. Physiol. Gastrointest. Liver Physiol. VL - 302 IS - 11 N2 - The rectoanal inhibitory reflex (RAIR) is important in gas and stool evacuation. We examined RAIR features in patients with chronic constipation who exhibited bloating with and without abdominal distension, to determine whether alterations in RAIR may be a factor in the pathogenesis of abdominal distension. Seventy-five female patients with chronic constipation with or without abdominal distension were included in the study. The presence or absence of abdominal distension was assessed according to the Rome II questionnaire. All patients underwent both RAIR and rectal sensitivity testing, and specific RAIR parameters were analyzed. Patients were divided into two groups: abdominal bloating with distension (D, n = 55) and abdominal bloating without distension (ND, n = 20). D had a longer time to the onset of anal sphincter inhibition (latency of inhibition) (P = 0.03) compared with ND. In logistic regression analysis, a combination of age, latency of inhibition and the time measured from onset of inhibition to the point of maximum inhibition predicted abdominal distension (P = 0.002). There were no differences between groups for the time from point of maximum inhibition to recovery and for the percentage of internal anal sphincter relaxation. This is the first study to examine the role of RAIR in patients with abdominal distension. Female patients with constipation and abdominal distension exhibited differences in the temporal characteristics of, but not in the degree of, anal sphincter relaxation compared with patients without distension. Since this study was uncontrolled, further studies are necessary to determine the contribution of altered anorectal reflexes to abdominal distension. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/22461025/Altered_temporal_characteristics_of_the_rectoanal_inhibitory_reflex_in_patients_with_abdominal_distension_ L2 - http://www.physiology.org/doi/full/10.1152/ajpgi.00400.2011?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -