Tags

Type your tag names separated by a space and hit enter

Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study.
Eur J Epidemiol 2012; 27(5):385-93EJ

Abstract

Open-angle glaucoma (OAG) is the commonest cause of irreversible blindness worldwide. Apart from an increased intraocular pressure (IOP), oxidative stress and an impaired ocular blood flow are supposed to contribute to OAG. The aim of this study was to determine whether the dietary intake of nutrients that either have anti-oxidative properties (carotenoids, vitamins, and flavonoids) or influence the blood flow (omega fatty acids and magnesium) is associated with incident OAG. We investigated this in a prospective population-based cohort, the Rotterdam Study. A total of 3502 participants aged 55 years and older for whom dietary data at baseline and ophthalmic data at baseline and follow-up were available and who did not have OAG at baseline were included. The ophthalmic examinations comprised measurements of the IOP and perimetry; dietary intake of nutrients was assessed by validated questionnaires and adjusted for energy intake. Cox proportional hazard regression analysis was applied to calculate hazard ratios of associations between the baseline intake of nutrients and incident OAG, adjusted for age, gender, IOP, IOP-lowering treatment, and body mass index. During an average follow-up of 9.7 years, 91 participants (2.6%) developed OAG. The hazard ratio for retinol equivalents (highest versus lowest tertile) was 0.45 (95% confidence interval 0.23-0.90), for vitamin B1 0.50 (0.25-0.98), and for magnesium 2.25 (1.16-4.38). The effects were stronger after the exclusion of participants taking supplements. Hence, a low intake of retinol equivalents and vitamin B1 (in line with hypothesis) and a high intake of magnesium (less unambiguous to interpret) appear to be associated with an increased risk of OAG.

Authors+Show Affiliations

Department of Epidemiology, Erasmus Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22461101

Citation

Ramdas, Wishal D., et al. "Nutrient Intake and Risk of Open-angle Glaucoma: the Rotterdam Study." European Journal of Epidemiology, vol. 27, no. 5, 2012, pp. 385-93.
Ramdas WD, Wolfs RC, Kiefte-de Jong JC, et al. Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. Eur J Epidemiol. 2012;27(5):385-93.
Ramdas, W. D., Wolfs, R. C., Kiefte-de Jong, J. C., Hofman, A., de Jong, P. T., Vingerling, J. R., & Jansonius, N. M. (2012). Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. European Journal of Epidemiology, 27(5), pp. 385-93. doi:10.1007/s10654-012-9672-z.
Ramdas WD, et al. Nutrient Intake and Risk of Open-angle Glaucoma: the Rotterdam Study. Eur J Epidemiol. 2012;27(5):385-93. PubMed PMID: 22461101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. AU - Ramdas,Wishal D, AU - Wolfs,Roger C W, AU - Kiefte-de Jong,Jessica C, AU - Hofman,Albert, AU - de Jong,Paulus T V M, AU - Vingerling,Johannes R, AU - Jansonius,Nomdo M, Y1 - 2012/03/30/ PY - 2011/10/30/received PY - 2012/02/23/accepted PY - 2012/3/31/entrez PY - 2012/3/31/pubmed PY - 2012/10/16/medline SP - 385 EP - 93 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 27 IS - 5 N2 - Open-angle glaucoma (OAG) is the commonest cause of irreversible blindness worldwide. Apart from an increased intraocular pressure (IOP), oxidative stress and an impaired ocular blood flow are supposed to contribute to OAG. The aim of this study was to determine whether the dietary intake of nutrients that either have anti-oxidative properties (carotenoids, vitamins, and flavonoids) or influence the blood flow (omega fatty acids and magnesium) is associated with incident OAG. We investigated this in a prospective population-based cohort, the Rotterdam Study. A total of 3502 participants aged 55 years and older for whom dietary data at baseline and ophthalmic data at baseline and follow-up were available and who did not have OAG at baseline were included. The ophthalmic examinations comprised measurements of the IOP and perimetry; dietary intake of nutrients was assessed by validated questionnaires and adjusted for energy intake. Cox proportional hazard regression analysis was applied to calculate hazard ratios of associations between the baseline intake of nutrients and incident OAG, adjusted for age, gender, IOP, IOP-lowering treatment, and body mass index. During an average follow-up of 9.7 years, 91 participants (2.6%) developed OAG. The hazard ratio for retinol equivalents (highest versus lowest tertile) was 0.45 (95% confidence interval 0.23-0.90), for vitamin B1 0.50 (0.25-0.98), and for magnesium 2.25 (1.16-4.38). The effects were stronger after the exclusion of participants taking supplements. Hence, a low intake of retinol equivalents and vitamin B1 (in line with hypothesis) and a high intake of magnesium (less unambiguous to interpret) appear to be associated with an increased risk of OAG. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/22461101/full_citation L2 - https://doi.org/10.1007/s10654-012-9672-z DB - PRIME DP - Unbound Medicine ER -