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Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin.

Abstract

OBJECTIVES

Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q10 (CoQ10) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls.

METHODS

This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men,18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ10 levels were standardized using blood lipids.

RESULTS

Serum TAS levels and CoQ10/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ10/LDL, CoQ10/triglycerides, and CoQ10/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ10 levels, and adjusted CoQ10 values of the CAPD and HD patients.

CONCLUSIONS

Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ10 levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, Meram Faculty of Medicine, University of Selcuk, Konya, Turkey.

    , , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers
    Female
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Oxidative Stress
    Peritoneal Dialysis
    Renal Dialysis
    Serum Albumin
    Serum Albumin, Human
    Ubiquinone

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22461118

    Citation

    Mehmetoglu, Idris, et al. "Oxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-modified Albumin." The International Journal of Artificial Organs, vol. 35, no. 3, 2012, pp. 226-32.
    Mehmetoglu I, Yerlikaya FH, Kurban S, et al. Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. Int J Artif Organs. 2012;35(3):226-32.
    Mehmetoglu, I., Yerlikaya, F. H., Kurban, S., Erdem, S. S., & Tonbul, Z. (2012). Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. The International Journal of Artificial Organs, 35(3), pp. 226-32. doi:10.5301/ijao.5000078.
    Mehmetoglu I, et al. Oxidative Stress Markers in Hemodialysis and Peritoneal Dialysis Patients, Including Coenzyme Q10 and Ischemia-modified Albumin. Int J Artif Organs. 2012;35(3):226-32. PubMed PMID: 22461118.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. AU - Mehmetoglu,Idris, AU - Yerlikaya,F Hümeyra, AU - Kurban,Sevil, AU - Erdem,S Sami, AU - Tonbul,Zeki, PY - 2011/10/07/accepted PY - 2012/3/31/entrez PY - 2012/3/31/pubmed PY - 2012/7/26/medline SP - 226 EP - 32 JF - The International journal of artificial organs JO - Int J Artif Organs VL - 35 IS - 3 N2 - OBJECTIVES: Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q10 (CoQ10) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls. METHODS: This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men,18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ10 levels were standardized using blood lipids. RESULTS: Serum TAS levels and CoQ10/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ10/LDL, CoQ10/triglycerides, and CoQ10/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ10 levels, and adjusted CoQ10 values of the CAPD and HD patients. CONCLUSIONS: Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ10 levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested. SN - 1724-6040 UR - https://www.unboundmedicine.com/medline/citation/22461118/Oxidative_stress_markers_in_hemodialysis_and_peritoneal_dialysis_patients_including_coenzyme_Q10_and_ischemia_modified_albumin_ L2 - http://journals.sagepub.com/doi/full/10.5301/ijao.5000078?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -