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Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older.
Neurobiol Aging 2012; 33(8):1851.e7-16NA

Abstract

Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older.

Authors+Show Affiliations

University Center for Geriatric Medicine, University of Groningen, Univerity Medical Center Groningen, Groningen, the Netherlands. g.j.izaks@umcg.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22464147

Citation

Izaks, Gerbrand J., et al. "Cholesteryl Ester Transfer Protein (CETP) Genotype and Cognitive Function in Persons Aged 35 Years or Older." Neurobiology of Aging, vol. 33, no. 8, 2012, pp. 1851.e7-16.
Izaks GJ, van der Knaap AM, Gansevoort RT, et al. Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. Neurobiol Aging. 2012;33(8):1851.e7-16.
Izaks, G. J., van der Knaap, A. M., Gansevoort, R. T., Navis, G., Slaets, J. P., & Dullaart, R. P. (2012). Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. Neurobiology of Aging, 33(8), pp. 1851.e7-16. doi:10.1016/j.neurobiolaging.2012.02.022.
Izaks GJ, et al. Cholesteryl Ester Transfer Protein (CETP) Genotype and Cognitive Function in Persons Aged 35 Years or Older. Neurobiol Aging. 2012;33(8):1851.e7-16. PubMed PMID: 22464147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. AU - Izaks,Gerbrand J, AU - van der Knaap,Aafke M, AU - Gansevoort,Ron T, AU - Navis,Gerjan, AU - Slaets,Joris P J, AU - Dullaart,Robin P F, Y1 - 2012/03/29/ PY - 2011/08/08/received PY - 2012/01/06/revised PY - 2012/02/21/accepted PY - 2012/4/3/entrez PY - 2012/4/3/pubmed PY - 2012/10/25/medline SP - 1851.e7 EP - 16 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 33 IS - 8 N2 - Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/22464147/Cholesteryl_Ester_Transfer_Protein__CETP__genotype_and_cognitive_function_in_persons_aged_35_years_or_older_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(12)00167-4 DB - PRIME DP - Unbound Medicine ER -