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Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older.

Abstract

Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older.

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  • Authors+Show Affiliations

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    University Center for Geriatric Medicine, University of Groningen, Univerity Medical Center Groningen, Groningen, the Netherlands. g.j.izaks@umcg.nl

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    Source

    Neurobiology of aging 33:8 2012 Aug pg 1851.e7-16

    MeSH

    Adult
    Age Distribution
    Aged
    Aged, 80 and over
    Aging
    Cholesterol Ester Transfer Proteins
    Cognition
    Cognition Disorders
    Female
    Genetic Markers
    Genetic Predisposition to Disease
    Genetic Variation
    Genotype
    Humans
    Male
    Middle Aged
    Netherlands
    Polymorphism, Single Nucleotide
    Prevalence
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22464147

    Citation

    Izaks, Gerbrand J., et al. "Cholesteryl Ester Transfer Protein (CETP) Genotype and Cognitive Function in Persons Aged 35 Years or Older." Neurobiology of Aging, vol. 33, no. 8, 2012, pp. 1851.e7-16.
    Izaks GJ, van der Knaap AM, Gansevoort RT, et al. Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. Neurobiol Aging. 2012;33(8):1851.e7-16.
    Izaks, G. J., van der Knaap, A. M., Gansevoort, R. T., Navis, G., Slaets, J. P., & Dullaart, R. P. (2012). Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. Neurobiology of Aging, 33(8), pp. 1851.e7-16. doi:10.1016/j.neurobiolaging.2012.02.022.
    Izaks GJ, et al. Cholesteryl Ester Transfer Protein (CETP) Genotype and Cognitive Function in Persons Aged 35 Years or Older. Neurobiol Aging. 2012;33(8):1851.e7-16. PubMed PMID: 22464147.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older. AU - Izaks,Gerbrand J, AU - van der Knaap,Aafke M, AU - Gansevoort,Ron T, AU - Navis,Gerjan, AU - Slaets,Joris P J, AU - Dullaart,Robin P F, Y1 - 2012/03/29/ PY - 2011/08/08/received PY - 2012/01/06/revised PY - 2012/02/21/accepted PY - 2012/4/3/entrez PY - 2012/4/3/pubmed PY - 2012/10/25/medline SP - 1851.e7 EP - 16 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 33 IS - 8 N2 - Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/22464147/Cholesteryl_Ester_Transfer_Protein__CETP__genotype_and_cognitive_function_in_persons_aged_35_years_or_older_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(12)00167-4 DB - PRIME DP - Unbound Medicine ER -