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A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma.
Eur J Cancer Prev. 2012 May; 21(3):268-73.EJ

Abstract

The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. ≤1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to--or greater in--case-control as compared with cohort studies. This indicates caution in the interpretation of results.

Authors+Show Affiliations

Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22465910

Citation

Tramacere, Irene, et al. "A Meta-analysis On Alcohol Drinking and the Risk of Hodgkin Lymphoma." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 21, no. 3, 2012, pp. 268-73.
Tramacere I, Pelucchi C, Bonifazi M, et al. A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. Eur J Cancer Prev. 2012;21(3):268-73.
Tramacere, I., Pelucchi, C., Bonifazi, M., Bagnardi, V., Rota, M., Bellocco, R., Scotti, L., Islami, F., Corrao, G., Boffetta, P., La Vecchia, C., & Negri, E. (2012). A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 21(3), 268-73. https://doi.org/10.1097/CEJ.0b013e328350b11b
Tramacere I, et al. A Meta-analysis On Alcohol Drinking and the Risk of Hodgkin Lymphoma. Eur J Cancer Prev. 2012;21(3):268-73. PubMed PMID: 22465910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on alcohol drinking and the risk of Hodgkin lymphoma. AU - Tramacere,Irene, AU - Pelucchi,Claudio, AU - Bonifazi,Martina, AU - Bagnardi,Vincenzo, AU - Rota,Matteo, AU - Bellocco,Rino, AU - Scotti,Lorenza, AU - Islami,Farhad, AU - Corrao,Giovanni, AU - Boffetta,Paolo, AU - La Vecchia,Carlo, AU - Negri,Eva, PY - 2012/4/3/entrez PY - 2012/4/3/pubmed PY - 2012/7/27/medline SP - 268 EP - 73 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur J Cancer Prev VL - 21 IS - 3 N2 - The role of alcohol intake in the risk of Hodgkin lymphoma (HL) is still largely unclear. To summarize the evidence on the issue, we carried out a meta-analysis of the available studies. We identified eight case-control and two cohort studies, including a total of 1488 cases of HL. We derived meta-analytic estimates using random-effects models, taking into account the correlation between estimates, and carried out a dose-risk analysis using nonlinear random-effects metaregression models. Compared with nondrinkers, the relative risk for alcohol consumers was 0.70 [95% confidence interval (CI), 0.60-0.81] overall, 0.66 (95% CI, 0.56-0.78) among case-control, and 0.92 (95% CI, 0.63-1.33) among cohort studies. Compared with nondrinkers, the pooled relative risks were 0.71 (95% CI, 0.57-0.89) for light (i.e. ≤1 drink/day) and 0.73 (95% CI, 0.60-0.87) for moderate-to-heavy (i.e. >1 drink/day) alcohol drinking. This meta-analysis suggests a favourable effect of alcohol on HL, in the absence, however, of a dose-risk relationship. The inverse association was restricted to--or greater in--case-control as compared with cohort studies. This indicates caution in the interpretation of results. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/22465910/A_meta_analysis_on_alcohol_drinking_and_the_risk_of_Hodgkin_lymphoma_ L2 - https://doi.org/10.1097/CEJ.0b013e328350b11b DB - PRIME DP - Unbound Medicine ER -