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Associations of insulin resistance and glycemic control with the risk of kidney stones.

Abstract

OBJECTIVE

The associations of insulin resistance and glycemic control with the risk of kidney stones were explored.

METHODS

Generally healthy Japanese (n=2,171) who visited Saiseikai Central Hospital (Tokyo, Japan) for a health check were included in a cross-sectional study. We calculated odds ratios (OR) of having kidney stones in terms of four measures: fasting serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), adjusting for possible risk factors for kidney stones.

RESULTS

Fasting serum insulin and HOMA-IR were non-significantly associated with the risk of kidney stones, whereas FPG and HbA1c were significantly associated. Compared with those with an FPG of <100 mg/dL, the ORs in those with an FPG of 100 to <126 mg/dL and ≥126 mg/dL were 1.38 (95% confidence interval [CI] =0.95-2.00) and 1.83 (95% CI =1.09-3.06) (p for trend =0.016). In relation to those with an HbA1c of <5.5%, the ORs in those with an HbA1c of 5.5 to <6.0%, 6.0% to <6.5% and ≥6.5% were 1.16 (95% CI =0.76-1.79), 1.25 (95% CI =0.70-2.23) and 1.98 (95% CI =1.11-3.52), respectively (p for trend =0.027). The significant associations between glycemic control measures and the risk of kidney stones were preserved even after the adjustment for factors related to insulin resistance.

CONCLUSION

Glycemic control could be an independent risk factor for kidney stones.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Saiseikai Central Hospital, Japan. ykabeyan@yahoo.co.jp

    , , , , ,

    Source

    MeSH

    Aged
    Blood Glucose
    Cross-Sectional Studies
    Female
    Glycated Hemoglobin A
    Humans
    Hyperglycemia
    Insulin
    Insulin Resistance
    Kidney Calculi
    Male
    Metabolic Syndrome
    Middle Aged
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22466823

    Citation

    Kabeya, Yusuke, et al. "Associations of Insulin Resistance and Glycemic Control With the Risk of Kidney Stones." Internal Medicine (Tokyo, Japan), vol. 51, no. 7, 2012, pp. 699-705.
    Kabeya Y, Kato K, Tomita M, et al. Associations of insulin resistance and glycemic control with the risk of kidney stones. Intern Med. 2012;51(7):699-705.
    Kabeya, Y., Kato, K., Tomita, M., Katsuki, T., Oikawa, Y., Shimada, A., & Atsumi, Y. (2012). Associations of insulin resistance and glycemic control with the risk of kidney stones. Internal Medicine (Tokyo, Japan), 51(7), pp. 699-705.
    Kabeya Y, et al. Associations of Insulin Resistance and Glycemic Control With the Risk of Kidney Stones. Intern Med. 2012;51(7):699-705. PubMed PMID: 22466823.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations of insulin resistance and glycemic control with the risk of kidney stones. AU - Kabeya,Yusuke, AU - Kato,Kiyoe, AU - Tomita,Masuomi, AU - Katsuki,Takeshi, AU - Oikawa,Yoichi, AU - Shimada,Akira, AU - Atsumi,Yoshihito, Y1 - 2012/04/01/ PY - 2012/4/3/entrez PY - 2012/4/3/pubmed PY - 2012/8/24/medline SP - 699 EP - 705 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 51 IS - 7 N2 - OBJECTIVE: The associations of insulin resistance and glycemic control with the risk of kidney stones were explored. METHODS: Generally healthy Japanese (n=2,171) who visited Saiseikai Central Hospital (Tokyo, Japan) for a health check were included in a cross-sectional study. We calculated odds ratios (OR) of having kidney stones in terms of four measures: fasting serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR), fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c), adjusting for possible risk factors for kidney stones. RESULTS: Fasting serum insulin and HOMA-IR were non-significantly associated with the risk of kidney stones, whereas FPG and HbA1c were significantly associated. Compared with those with an FPG of <100 mg/dL, the ORs in those with an FPG of 100 to <126 mg/dL and ≥126 mg/dL were 1.38 (95% confidence interval [CI] =0.95-2.00) and 1.83 (95% CI =1.09-3.06) (p for trend =0.016). In relation to those with an HbA1c of <5.5%, the ORs in those with an HbA1c of 5.5 to <6.0%, 6.0% to <6.5% and ≥6.5% were 1.16 (95% CI =0.76-1.79), 1.25 (95% CI =0.70-2.23) and 1.98 (95% CI =1.11-3.52), respectively (p for trend =0.027). The significant associations between glycemic control measures and the risk of kidney stones were preserved even after the adjustment for factors related to insulin resistance. CONCLUSION: Glycemic control could be an independent risk factor for kidney stones. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/22466823/full_citation L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/51.6426?from=PubMed DB - PRIME DP - Unbound Medicine ER -