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Concord grape juice supplementation and neurocognitive function in human aging.
J Agric Food Chem. 2012 Jun 13; 60(23):5736-42.JA

Abstract

Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated with health benefits including improvement in cognition and neuronal function with aging. Concord grape juice contains polyphenols, including anthocyanins and flavanols, and previous research has shown improvement in a number of human health conditions with grape juice supplementation. In the current study, older adult subjects with mild cognitive impairment consumed Concord grape juice or placebo for 16 weeks and were administered assessments of memory function and brain activation pre- and postintervention. Participants who consumed grape juice showed reduced semantic interference on memory tasks. Relatively greater activation in anterior and posterior regions of the right hemisphere was also observed with functional magnetic resonance imaging in the grape juice treated subjects. These findings provide further evidence that Concord grape juice can enhance neurocognitive function in older adults with mild memory decline.

Authors+Show Affiliations

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati Academic Health Center , P.O. Box 670559, Cincinnati, Ohio 45267-0559, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22468945

Citation

Krikorian, Robert, et al. "Concord Grape Juice Supplementation and Neurocognitive Function in Human Aging." Journal of Agricultural and Food Chemistry, vol. 60, no. 23, 2012, pp. 5736-42.
Krikorian R, Boespflug EL, Fleck DE, et al. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012;60(23):5736-42.
Krikorian, R., Boespflug, E. L., Fleck, D. E., Stein, A. L., Wightman, J. D., Shidler, M. D., & Sadat-Hossieny, S. (2012). Concord grape juice supplementation and neurocognitive function in human aging. Journal of Agricultural and Food Chemistry, 60(23), 5736-42. https://doi.org/10.1021/jf300277g
Krikorian R, et al. Concord Grape Juice Supplementation and Neurocognitive Function in Human Aging. J Agric Food Chem. 2012 Jun 13;60(23):5736-42. PubMed PMID: 22468945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concord grape juice supplementation and neurocognitive function in human aging. AU - Krikorian,Robert, AU - Boespflug,Erin L, AU - Fleck,David E, AU - Stein,Amanda L, AU - Wightman,Jolynne D, AU - Shidler,Marcelle D, AU - Sadat-Hossieny,Sara, Y1 - 2012/04/09/ PY - 2012/4/4/entrez PY - 2012/4/4/pubmed PY - 2014/7/19/medline SP - 5736 EP - 42 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 60 IS - 23 N2 - Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated with health benefits including improvement in cognition and neuronal function with aging. Concord grape juice contains polyphenols, including anthocyanins and flavanols, and previous research has shown improvement in a number of human health conditions with grape juice supplementation. In the current study, older adult subjects with mild cognitive impairment consumed Concord grape juice or placebo for 16 weeks and were administered assessments of memory function and brain activation pre- and postintervention. Participants who consumed grape juice showed reduced semantic interference on memory tasks. Relatively greater activation in anterior and posterior regions of the right hemisphere was also observed with functional magnetic resonance imaging in the grape juice treated subjects. These findings provide further evidence that Concord grape juice can enhance neurocognitive function in older adults with mild memory decline. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22468945/Concord_grape_juice_supplementation_and_neurocognitive_function_in_human_aging_ L2 - https://doi.org/10.1021/jf300277g DB - PRIME DP - Unbound Medicine ER -