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Characterization of periostin expression in human endometrium and endometriotic lesions.
Gynecol Endocrinol. 2012 Oct; 28(10):815-8.GE

Abstract

OBJECTIVE(S)

To investigate the expression of periostin in the eutopic and ectopic endometrium of women diagnosed as endometriosis and evaluate the role of periostin in the pathogenesis of endometriosis.

STUDY DESIGN

In this study, the expression of periostin was evaluated in the endometrial specimens from 35 women diagnosed as endometriosis and from 30 healthy women. To assess the presence and localization of periostin throughout the menstrual cycle in both eutopic and ectopic endometrium of women with endometriosis, microscopic evaluation was conducted. It was also subsequently compared with normal endometrium.

RESULTS

In the eutopic and ectopic endometrium of women with endometriosis, immunoreactivities of periostin increased compared with those of normal endometrium. We also observed a cyclic variation in the eutopic stromal periostin immunoreactivity throughout their menstrual cycle because higher H score values were observed in the proliferative phase than those in the secretory phase.

CONCLUSION(S)

These findings indicated that periostin may be involved in the pathophysiology of endometriosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22471299

Citation

Shen, Liang, et al. "Characterization of Periostin Expression in Human Endometrium and Endometriotic Lesions." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 28, no. 10, 2012, pp. 815-8.
Shen L, Liu P, Zhang P, et al. Characterization of periostin expression in human endometrium and endometriotic lesions. Gynecol Endocrinol. 2012;28(10):815-8.
Shen, L., Liu, P., Zhang, P., Zhang, X., & Cui, J. (2012). Characterization of periostin expression in human endometrium and endometriotic lesions. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 28(10), 815-8. https://doi.org/10.3109/09513590.2012.671387
Shen L, et al. Characterization of Periostin Expression in Human Endometrium and Endometriotic Lesions. Gynecol Endocrinol. 2012;28(10):815-8. PubMed PMID: 22471299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of periostin expression in human endometrium and endometriotic lesions. AU - Shen,Liang, AU - Liu,Peishu, AU - Zhang,Peihai, AU - Zhang,Xiaolei, AU - Cui,Jing, Y1 - 2012/04/03/ PY - 2012/4/5/entrez PY - 2012/4/5/pubmed PY - 2013/1/31/medline SP - 815 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 28 IS - 10 N2 - OBJECTIVE(S): To investigate the expression of periostin in the eutopic and ectopic endometrium of women diagnosed as endometriosis and evaluate the role of periostin in the pathogenesis of endometriosis. STUDY DESIGN: In this study, the expression of periostin was evaluated in the endometrial specimens from 35 women diagnosed as endometriosis and from 30 healthy women. To assess the presence and localization of periostin throughout the menstrual cycle in both eutopic and ectopic endometrium of women with endometriosis, microscopic evaluation was conducted. It was also subsequently compared with normal endometrium. RESULTS: In the eutopic and ectopic endometrium of women with endometriosis, immunoreactivities of periostin increased compared with those of normal endometrium. We also observed a cyclic variation in the eutopic stromal periostin immunoreactivity throughout their menstrual cycle because higher H score values were observed in the proliferative phase than those in the secretory phase. CONCLUSION(S): These findings indicated that periostin may be involved in the pathophysiology of endometriosis. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/22471299/Characterization_of_periostin_expression_in_human_endometrium_and_endometriotic_lesions_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2012.671387 DB - PRIME DP - Unbound Medicine ER -