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Light-chain deposition disease of the kidney: a case report.
Ultrastruct Pathol. 2012 Apr; 36(2):134-8.UP

Abstract

A 41-year-old man was admitted for evaluation of nephrotic syndrome associated with microhematuria, hypertension, and moderate renal failure. In serum and urine samples, monoclonal IgG-lambda was detected. Bone marrow examination showed normal representation of all cell lines with normal range of plasma cells. Renal biopsy demonstrated diabetes-like nodular glomerulosclerosis. Immunofluorescence failed to demonstrate the presence of kappa or lambda light chains in the kidney. Electron microcopy showed granular electron-dense deposits along the glomerular basement membranes and in the mesangial nodules. The patient was diagnosed as having light-chain deposition disease (LCDD) without evidence of plasma cell dyscrasia. This report was designed to stress the significant challenges that remain in the diagnosis of LCDD-related glomerulopathy. The salient morphological features that help in making an accurate diagnosis are discussed.

Authors+Show Affiliations

Electron Microscopy Laboratory, Faculty of Medicine of Tunis, Tunis, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22471437

Citation

Darouich, Sihem, et al. "Light-chain Deposition Disease of the Kidney: a Case Report." Ultrastructural Pathology, vol. 36, no. 2, 2012, pp. 134-8.
Darouich S, Goucha R, Jaafoura MH, et al. Light-chain deposition disease of the kidney: a case report. Ultrastruct Pathol. 2012;36(2):134-8.
Darouich, S., Goucha, R., Jaafoura, M. H., Zekri, S., Kheder, A., & Maiz, H. B. (2012). Light-chain deposition disease of the kidney: a case report. Ultrastructural Pathology, 36(2), 134-8. https://doi.org/10.3109/01913123.2011.642464
Darouich S, et al. Light-chain Deposition Disease of the Kidney: a Case Report. Ultrastruct Pathol. 2012;36(2):134-8. PubMed PMID: 22471437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light-chain deposition disease of the kidney: a case report. AU - Darouich,Sihem, AU - Goucha,Rym, AU - Jaafoura,Mohamed Habib, AU - Zekri,Semy, AU - Kheder,Adel, AU - Maiz,Hedi Ben, PY - 2012/4/5/entrez PY - 2012/4/5/pubmed PY - 2012/8/10/medline SP - 134 EP - 8 JF - Ultrastructural pathology JO - Ultrastruct Pathol VL - 36 IS - 2 N2 - A 41-year-old man was admitted for evaluation of nephrotic syndrome associated with microhematuria, hypertension, and moderate renal failure. In serum and urine samples, monoclonal IgG-lambda was detected. Bone marrow examination showed normal representation of all cell lines with normal range of plasma cells. Renal biopsy demonstrated diabetes-like nodular glomerulosclerosis. Immunofluorescence failed to demonstrate the presence of kappa or lambda light chains in the kidney. Electron microcopy showed granular electron-dense deposits along the glomerular basement membranes and in the mesangial nodules. The patient was diagnosed as having light-chain deposition disease (LCDD) without evidence of plasma cell dyscrasia. This report was designed to stress the significant challenges that remain in the diagnosis of LCDD-related glomerulopathy. The salient morphological features that help in making an accurate diagnosis are discussed. SN - 1521-0758 UR - https://www.unboundmedicine.com/medline/citation/22471437/Light_chain_deposition_disease_of_the_kidney:_a_case_report_ L2 - http://www.tandfonline.com/doi/full/10.3109/01913123.2011.642464 DB - PRIME DP - Unbound Medicine ER -