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Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study after a longer follow-up.

Abstract

In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a subsample was used to correct for dietary measurement errors. When comparing the highest vs. lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk [hazard ratio (HR) 0.77; 95% confidence interval (CI) 0.57-1.04; p for trend 0.02], between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.36-0.97; p for trend 0.03) and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.38-1.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations, none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC, respectively.

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  • Authors+Show Affiliations

    ,

    Unit of Nutrition, Environment and Cancer, Programme of Epidemiological Research, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. cagonzalez@iconcologia.net

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 131:12 2012 Dec 15 pg 2910-9

    MeSH

    Adenocarcinoma
    Adult
    Aged
    Calibration
    Diet
    Europe
    Female
    Follow-Up Studies
    Fruit
    Humans
    Life Style
    Male
    Middle Aged
    Risk Factors
    Stomach Neoplasms
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22473701

    Citation

    Gonzalez, Carlos A., et al. "Fruit and Vegetable Intake and the Risk of Gastric Adenocarcinoma: a Reanalysis of the European Prospective Investigation Into Cancer and Nutrition (EPIC-EURGAST) Study After a Longer Follow-up." International Journal of Cancer, vol. 131, no. 12, 2012, pp. 2910-9.
    Gonzalez CA, Lujan-Barroso L, Bueno-de-Mesquita HB, et al. Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study after a longer follow-up. Int J Cancer. 2012;131(12):2910-9.
    Gonzalez, C. A., Lujan-Barroso, L., Bueno-de-Mesquita, H. B., Jenab, M., Duell, E. J., Agudo, A., ... Riboli, E. (2012). Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study after a longer follow-up. International Journal of Cancer, 131(12), pp. 2910-9. doi:10.1002/ijc.27565.
    Gonzalez CA, et al. Fruit and Vegetable Intake and the Risk of Gastric Adenocarcinoma: a Reanalysis of the European Prospective Investigation Into Cancer and Nutrition (EPIC-EURGAST) Study After a Longer Follow-up. Int J Cancer. 2012 Dec 15;131(12):2910-9. PubMed PMID: 22473701.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study after a longer follow-up. AU - Gonzalez,Carlos A, AU - Lujan-Barroso,Leila, AU - Bueno-de-Mesquita,H B, AU - Jenab,Mazda, AU - Duell,Eric J, AU - Agudo,Antonio, AU - Tjønneland,Anne, AU - Boutron-Ruault,Marie Christine, AU - Clavel-Chapelon,Françoise, AU - Touillaud,Marina, AU - Teucher,Birgit, AU - Kaaks,Rudolf, AU - Boeing,Heiner, AU - Steffen,Annika, AU - Trichopoulou,Antonia, AU - Roukos,Dimitrios, AU - Karapetyan,Tina, AU - Palli,Domenico, AU - Tagliabue,Giovanna, AU - Mattiello,Amalia, AU - Tumino,Rosario, AU - Ricceri,Fulvio, AU - Siersema,Peter D, AU - Numans,Mattijs E, AU - Peeters,Petra P H, AU - Parr,Christine L, AU - Skeie,Guri, AU - Lund,Eiliv, AU - Quirós,J Ramón, AU - Sánchez-Cantalejo,Emilio, AU - Navarro,Carmen, AU - Barricarte,Aurelio, AU - Dorronsoro,Miren, AU - Ehrnström,Roy, AU - Regner,Sara, AU - Khaw,Kay-Tee, AU - Wareham,Nick, AU - Key,Timothy J, AU - Crowe,Francesca L, AU - Blaker,Hendrik, AU - Romieu,Isabelle, AU - Riboli,Elio, Y1 - 2012/04/26/ PY - 2011/10/17/received PY - 2012/01/05/accepted PY - 2012/4/5/entrez PY - 2012/4/5/pubmed PY - 2012/12/27/medline SP - 2910 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 131 IS - 12 N2 - In a previous European prospective investigation into cancer and nutrition (EPIC) analysis, we found an inverse association between total intake of vegetables, onion and garlic, and risk of intestinal gastric cancer (GC) and between citrus fruit and risk of cardia GC. The aim of this study is to reanalyze the effect of fruit and vegetables (F&V), based on a longer follow-up and twice the number of GC cases. Subjects are 477,312 men and women mostly aged 35 to 70 years participating in the EPIC cohort, including 683 gastric adenocarcinomas with 11 years of follow-up. Information on diet and lifestyle was collected at baseline. A calibration study in a subsample was used to correct for dietary measurement errors. When comparing the highest vs. lowest quintile of intake, we found an inverse association between total intake of V&F and GC risk [hazard ratio (HR) 0.77; 95% confidence interval (CI) 0.57-1.04; p for trend 0.02], between fresh fruit and risk of the diffuse type (HR 0.59; 95% CI 0.36-0.97; p for trend 0.03) and an inverse association between citrus fruit and risk of cardia cancer (HR 0.61; 95% CI 0.38-1.00, p for trend 0.01). Although calibration revealed somewhat stronger inverse associations, none of the risks reached statistical significance. There was no association between total or specific vegetables intake and GC risk. The inverse association between fresh fruit and citrus fruits and risk of GC seems to be restricted to smokers and the Northern European countries. Fresh fruit and citrus fruit consumption may protect against diffuse and cardia GC, respectively. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/22473701/Fruit_and_vegetable_intake_and_the_risk_of_gastric_adenocarcinoma:_a_reanalysis_of_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC_EURGAST__study_after_a_longer_follow_up_ L2 - https://doi.org/10.1002/ijc.27565 DB - PRIME DP - Unbound Medicine ER -