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Cochrane review on 'Statins for the treatment of dementia'.
Int J Geriatr Psychiatry. 2013 Feb; 28(2):119-26.IJ

Abstract

OBJECTIVES

This review aimed to assess the clinical efficacy and tolerability of statins in the treatment of dementia.

METHODS

We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS, as well as many trials registries and grey literature sources (27 October 2008). Double-blind, randomized controlled trials of statins given for at least 6 months in people with a diagnosis of dementia were included. Two independent authors extracted and assessed data independently against the inclusion criteria. Data were pooled where appropriate and entered into a meta-analysis.

RESULTS

Three studies were identified (748 participants, age range 50-90 years). All patients had a diagnosis of probable or possible Alzheimer's disease according to standard criteria, and most patients were established on a cholinesterase inhibitor. Change in Alzheimer's Disease Assessment Scale cognitive subscale from baseline was a primary outcome in three studies; when data were pooled, statins did not provide any beneficial effect in this cognitive measure (mean difference -1.12; 95% confidence interval -3.99, 1.75; p = 0.44). All studies provided a change in Mini-Mental State Examination from baseline; there was no significant benefit from statins in this cognitive measure when the data were pooled (mean difference -1.53; 95% confidence interval -3.28; 0.21, p = 0.08). There were no studies identified assessing the role of statins in treatment of vascular dementia. There was no evidence that statins were detrimental to cognition.

CONCLUSIONS

There is insufficient evidence to recommend statins for the treatment of dementia.

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Authors+Show Affiliations

McGuinness B
School of Medicine, National University of Ireland, Galway, Ireland. bernadette.mcguinness@nuigalway.ie
O'Hare J
No affiliation info available
Craig D
No affiliation info available
Bullock R
No affiliation info available
Malouf R
No affiliation info available
Passmore P
No affiliation info available

MeSH

AgedCholesterolDementiaHumansHydroxymethylglutaryl-CoA Reductase InhibitorsRandomized Controlled Trials as Topic

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

22473869

Citation

McGuinness, Bernadette, et al. "Cochrane Review On 'Statins for the Treatment of Dementia'." International Journal of Geriatric Psychiatry, vol. 28, no. 2, 2013, pp. 119-26.
McGuinness B, O'Hare J, Craig D, et al. Cochrane review on 'Statins for the treatment of dementia'. Int J Geriatr Psychiatry. 2013;28(2):119-26.
McGuinness, B., O'Hare, J., Craig, D., Bullock, R., Malouf, R., & Passmore, P. (2013). Cochrane review on 'Statins for the treatment of dementia'. International Journal of Geriatric Psychiatry, 28(2), 119-26. https://doi.org/10.1002/gps.3797
McGuinness B, et al. Cochrane Review On 'Statins for the Treatment of Dementia'. Int J Geriatr Psychiatry. 2013;28(2):119-26. PubMed PMID: 22473869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cochrane review on 'Statins for the treatment of dementia'. AU - McGuinness,Bernadette, AU - O'Hare,John, AU - Craig,David, AU - Bullock,Roger, AU - Malouf,Reem, AU - Passmore,Peter, Y1 - 2012/04/02/ PY - 2011/05/23/received PY - 2012/02/16/accepted PY - 2012/4/5/entrez PY - 2012/4/5/pubmed PY - 2013/7/9/medline SP - 119 EP - 26 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 28 IS - 2 N2 - OBJECTIVES: This review aimed to assess the clinical efficacy and tolerability of statins in the treatment of dementia. METHODS: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS, as well as many trials registries and grey literature sources (27 October 2008). Double-blind, randomized controlled trials of statins given for at least 6 months in people with a diagnosis of dementia were included. Two independent authors extracted and assessed data independently against the inclusion criteria. Data were pooled where appropriate and entered into a meta-analysis. RESULTS: Three studies were identified (748 participants, age range 50-90 years). All patients had a diagnosis of probable or possible Alzheimer's disease according to standard criteria, and most patients were established on a cholinesterase inhibitor. Change in Alzheimer's Disease Assessment Scale cognitive subscale from baseline was a primary outcome in three studies; when data were pooled, statins did not provide any beneficial effect in this cognitive measure (mean difference -1.12; 95% confidence interval -3.99, 1.75; p = 0.44). All studies provided a change in Mini-Mental State Examination from baseline; there was no significant benefit from statins in this cognitive measure when the data were pooled (mean difference -1.53; 95% confidence interval -3.28; 0.21, p = 0.08). There were no studies identified assessing the role of statins in treatment of vascular dementia. There was no evidence that statins were detrimental to cognition. CONCLUSIONS: There is insufficient evidence to recommend statins for the treatment of dementia. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/22473869/Cochrane_review_on_'Statins_for_the_treatment_of_dementia'_ L2 - https://doi.org/10.1002/gps.3797 DB - PRIME DP - Unbound Medicine ER -