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Cytoskeleton as an emerging target of anthrax toxins.

Abstract

Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.

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  • Authors+Show Affiliations

    ,

    Unité Interactions Hôte-Agents pathogènes, Institut de Recherche Biomédicale des Armées, Centre de Recherche du Service de Santé des Armées, BP 87, 24 avenue des Maquis du Grésivaudan 38702 La Tronche Cedex, France. yannick.trescos@yahoo.fr

    Source

    Toxins 4:2 2012 Feb pg 83-97

    MeSH

    Antigens, Bacterial
    Bacillus anthracis
    Bacterial Toxins
    Cytoskeleton
    Extracellular Matrix
    Host-Pathogen Interactions
    Humans
    Neoplasm Proteins
    Protein Binding
    Receptors, Cell Surface

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22474568