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Chemical composition and biological activity of essential oil from Pulicaria undulata from Yemen.
Nat Prod Commun. 2012 Feb; 7(2):257-60.NP

Abstract

The chemical composition of the essential oil obtained from the leaves of Pulicaria undulata Gamal Ed Din (syn P. orientalis sensu Schwartz and P. jaubertii Gamal Ed Din) was analyzed by GC-MS. Major compounds of P. undulata oil were the oxygenated monoterpenenes, carvotanacetone (91.4%) and 2,5-dimethoxy-p-cymene (2.6.%). The antimicrobial activity of the essential oil was evaluated against six microorganisms, Escherichia coli Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Candida albicans, using disc diffusion and broth microdilution methods. The oil showed the strongest bactericidal activity against Staphylococcus aureus and methicillin-resistant S. aureus, as well as Candida albicans. The essential oil showed moderate cytotoxic activity against MCF-7 breast tumor cells, with an IC50 of 64.6 +/- 13.7 microg/mL. Bioautographic assays were used to evaluate the acetylcholinesterase inhibitory effect as well as antifungal activity of the oil against Cladosporium cucumerinum.

Authors+Show Affiliations

Pharmacognosy Department, Faculty of Pharmacy, Sana'a University, P. O. Box 13150, Sana'a, Yemen. alinasser9678@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22474974

Citation

Ali, Nasser A Awadh, et al. "Chemical Composition and Biological Activity of Essential Oil From Pulicaria Undulata From Yemen." Natural Product Communications, vol. 7, no. 2, 2012, pp. 257-60.
Ali NA, Sharopov FS, Alhaj M, et al. Chemical composition and biological activity of essential oil from Pulicaria undulata from Yemen. Nat Prod Commun. 2012;7(2):257-60.
Ali, N. A., Sharopov, F. S., Alhaj, M., Hill, G. M., Porzel, A., Arnold, N., Setzer, W. N., Schmidt, J., & Wessjohann, L. (2012). Chemical composition and biological activity of essential oil from Pulicaria undulata from Yemen. Natural Product Communications, 7(2), 257-60.
Ali NA, et al. Chemical Composition and Biological Activity of Essential Oil From Pulicaria Undulata From Yemen. Nat Prod Commun. 2012;7(2):257-60. PubMed PMID: 22474974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and biological activity of essential oil from Pulicaria undulata from Yemen. AU - Ali,Nasser A Awadh, AU - Sharopov,Farukh S, AU - Alhaj,Mehdi, AU - Hill,Gabrielle M, AU - Porzel,Andrea, AU - Arnold,Norbert, AU - Setzer,William N, AU - Schmidt,Jürgen, AU - Wessjohann,Ludger, PY - 2012/4/6/entrez PY - 2012/4/6/pubmed PY - 2012/4/25/medline SP - 257 EP - 60 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 2 N2 - The chemical composition of the essential oil obtained from the leaves of Pulicaria undulata Gamal Ed Din (syn P. orientalis sensu Schwartz and P. jaubertii Gamal Ed Din) was analyzed by GC-MS. Major compounds of P. undulata oil were the oxygenated monoterpenenes, carvotanacetone (91.4%) and 2,5-dimethoxy-p-cymene (2.6.%). The antimicrobial activity of the essential oil was evaluated against six microorganisms, Escherichia coli Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant S. aureus, Bacillus subtilis, and Candida albicans, using disc diffusion and broth microdilution methods. The oil showed the strongest bactericidal activity against Staphylococcus aureus and methicillin-resistant S. aureus, as well as Candida albicans. The essential oil showed moderate cytotoxic activity against MCF-7 breast tumor cells, with an IC50 of 64.6 +/- 13.7 microg/mL. Bioautographic assays were used to evaluate the acetylcholinesterase inhibitory effect as well as antifungal activity of the oil against Cladosporium cucumerinum. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22474974/Chemical_composition_and_biological_activity_of_essential_oil_from_Pulicaria_undulata_from_Yemen_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -