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[Relationship of sperm morphology with reproductive hormone levels in infertile men].
Zhonghua Nan Ke Xue. 2012 Mar; 18(3):243-7.ZN

Abstract

OBJECTIVE

To investigate the relationship of sperm morphology with reproductive hormones in infertile men and the pathogenesis of teratozoospermia.

METHODS

This study included 90 infertile men aged 25 - 40 years. We measured their testis volumes using the Prader orchidometer, conducted routine semen analyses according to the WHO laboratory standard, and determined the concentrations of reproductive hormones and sex hormone-binding globulin (SHBG) by chemiluminescence and the levels of free testosterone (FT) and bioavailable testosterone (BioT).

RESULTS

All the subjects showed normal sperm concentration. Based on the results of semen morphology analysis, the 90 infertile men were equally divided into groups 1 (morphologically normal sperm <4%), 2 (morphologically normal sperm > or = 4% and <10%), and 3 (morphologically normal sperm > or = 10%), with no significant differences in age among the three groups (P>0.05). The volumes of the left testis were (14.27 +/- 3.65) ml, (16.90 +/- 3.57) ml and (14.57 +/- 3.57) ml, respectively (P = 0.006 group 1 vs group 2, P = 0.741 group 1 vs group 3, P = 0.014 group 2 vs group 3), and those of the right testis were (14.60 +/- 3.70) ml, (16.60 +/- 3.35) ml and (14.67 +/- 3.54) ml, respectively (P = 0.050). There were no significant differences among the three groups in prolactin, follicle-stimulating hormone, luteinising hormone, estradiol, total testosterone and SHBG, (P>0.05). The levels of serum FT were (0.25 +/- 0.07) nmol/L, (0.29 +/- 0.07) nmol/L and (0.31 +/- 0.13) nmol/L (P = 0.086 group 1 vs group 2, P= 0.010 group 1 vs group 3, P= 0.364 group 2 vs group 3), and those of BioT were (5.81 +/- 1.58) nmol/L, (6.78 +/- 1.55) nmol/L and (7.29 +/- 3.02) nmol/L, respectively (P = 0.086 group 1 vs group 2, P = 0.010 group 1 vs group 3, P = 0.364 group 2 vs group 3). The percentage of morphologically normal sperm was positively correlated with the levels of serum FT and BioT (P<0.05).

CONCLUSION

The higher the levels of serum FT and BioT, the higher the percentage of morphologically normal sperm, which suggests that serum FT and BioT might be involved in the pathogenesis of teratozoospermia.

Authors+Show Affiliations

Department of Urology, Center of Reproductive Medicine, Beijing University Third Hospital, Beijing 10019, China. tangwenhao9696@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

22474991

Citation

Tang, Wen-Hao, et al. "[Relationship of Sperm Morphology With Reproductive Hormone Levels in Infertile Men]." Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 18, no. 3, 2012, pp. 243-7.
Tang WH, Jiang H, Ma LL, et al. [Relationship of sperm morphology with reproductive hormone levels in infertile men]. Zhonghua Nan Ke Xue. 2012;18(3):243-7.
Tang, W. H., Jiang, H., Ma, L. L., Hong, K., Zhong, Q., Yang, C. S., Zhao, L. M., Liu, D. F., Mao, J. M., Yang, Y., Chen, Q., Yuan, R. P., Zhang, X., Li, B., & Wei, N. (2012). [Relationship of sperm morphology with reproductive hormone levels in infertile men]. Zhonghua Nan Ke Xue = National Journal of Andrology, 18(3), 243-7.
Tang WH, et al. [Relationship of Sperm Morphology With Reproductive Hormone Levels in Infertile Men]. Zhonghua Nan Ke Xue. 2012;18(3):243-7. PubMed PMID: 22474991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship of sperm morphology with reproductive hormone levels in infertile men]. AU - Tang,Wen-Hao, AU - Jiang,Hui, AU - Ma,Lu-Lin, AU - Hong,Kai, AU - Zhong,Qun, AU - Yang,Chi-Sun, AU - Zhao,Lian-Ming, AU - Liu,De-Feng, AU - Mao,Jia-Ming, AU - Yang,Yi, AU - Chen,Qian, AU - Yuan,Ren-Pei, AU - Zhang,Xin, AU - Li,Bin, AU - Wei,Nan, PY - 2012/4/6/entrez PY - 2012/4/6/pubmed PY - 2013/1/25/medline SP - 243 EP - 7 JF - Zhonghua nan ke xue = National journal of andrology JO - Zhonghua Nan Ke Xue VL - 18 IS - 3 N2 - OBJECTIVE: To investigate the relationship of sperm morphology with reproductive hormones in infertile men and the pathogenesis of teratozoospermia. METHODS: This study included 90 infertile men aged 25 - 40 years. We measured their testis volumes using the Prader orchidometer, conducted routine semen analyses according to the WHO laboratory standard, and determined the concentrations of reproductive hormones and sex hormone-binding globulin (SHBG) by chemiluminescence and the levels of free testosterone (FT) and bioavailable testosterone (BioT). RESULTS: All the subjects showed normal sperm concentration. Based on the results of semen morphology analysis, the 90 infertile men were equally divided into groups 1 (morphologically normal sperm <4%), 2 (morphologically normal sperm > or = 4% and <10%), and 3 (morphologically normal sperm > or = 10%), with no significant differences in age among the three groups (P>0.05). The volumes of the left testis were (14.27 +/- 3.65) ml, (16.90 +/- 3.57) ml and (14.57 +/- 3.57) ml, respectively (P = 0.006 group 1 vs group 2, P = 0.741 group 1 vs group 3, P = 0.014 group 2 vs group 3), and those of the right testis were (14.60 +/- 3.70) ml, (16.60 +/- 3.35) ml and (14.67 +/- 3.54) ml, respectively (P = 0.050). There were no significant differences among the three groups in prolactin, follicle-stimulating hormone, luteinising hormone, estradiol, total testosterone and SHBG, (P>0.05). The levels of serum FT were (0.25 +/- 0.07) nmol/L, (0.29 +/- 0.07) nmol/L and (0.31 +/- 0.13) nmol/L (P = 0.086 group 1 vs group 2, P= 0.010 group 1 vs group 3, P= 0.364 group 2 vs group 3), and those of BioT were (5.81 +/- 1.58) nmol/L, (6.78 +/- 1.55) nmol/L and (7.29 +/- 3.02) nmol/L, respectively (P = 0.086 group 1 vs group 2, P = 0.010 group 1 vs group 3, P = 0.364 group 2 vs group 3). The percentage of morphologically normal sperm was positively correlated with the levels of serum FT and BioT (P<0.05). CONCLUSION: The higher the levels of serum FT and BioT, the higher the percentage of morphologically normal sperm, which suggests that serum FT and BioT might be involved in the pathogenesis of teratozoospermia. SN - 1009-3591 UR - https://www.unboundmedicine.com/medline/citation/22474991/[Relationship_of_sperm_morphology_with_reproductive_hormone_levels_in_infertile_men]_ L2 - https://medlineplus.gov/maleinfertility.html DB - PRIME DP - Unbound Medicine ER -