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Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL.

Abstract

Alterations in gray matter density as well as cognitive impairments are commonly described in patients with schizophrenia (SCH patients). Both gray matter deficits and cognitive impairments have recently been discussed to represent vulnerability markers of schizophrenia. The counterintuitive finding of better cognitive performance in patients with schizophrenia and cannabis use (SCH+CAN patients) compared to cannabis naïve patients is discussed as a reflection of lower vulnerability for schizophrenia in at least one subgroup of SCH+CAN patients. We hypothesized that SCH+CAN patients would display fewer gray matter deficits compared to SCH patients reflecting their presumed lower vulnerability. We therefore compared gray matter density in 30 first episode SCH+CAN and 24 first episode SCH patients using a fast diffeomorphic registration algorithm (DARTEL) and voxel-based morphometry (VBM). We found less severe cognitive impairments and middle frontal gray matter deficits in the SCH+CAN patients. In the pooled sample gray matter density was positively associated with cognitive functioning. Results may support the hypothesis of a lower biological vulnerability in at least one subgroup of SCH+CAN patients.

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  • Authors+Show Affiliations

    ,

    Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany.

    , , ,

    Source

    Schizophrenia research 138:2-3 2012 Jul pg 183-7

    MeSH

    Adult
    Case-Control Studies
    Cognition
    Cognition Disorders
    Female
    Humans
    Magnetic Resonance Imaging
    Male
    Marijuana Smoking
    Nerve Fibers, Unmyelinated
    Neuropsychological Tests
    Organ Size
    Schizophrenia

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22475382

    Citation

    Schnell, Thomas, et al. "Increased Gray Matter Density in Patients With Schizophrenia and Cannabis Use: a Voxel-based Morphometric Study Using DARTEL." Schizophrenia Research, vol. 138, no. 2-3, 2012, pp. 183-7.
    Schnell T, Kleiman A, Gouzoulis-Mayfrank E, et al. Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. Schizophr Res. 2012;138(2-3):183-7.
    Schnell, T., Kleiman, A., Gouzoulis-Mayfrank, E., Daumann, J., & Becker, B. (2012). Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. Schizophrenia Research, 138(2-3), pp. 183-7. doi:10.1016/j.schres.2012.03.021.
    Schnell T, et al. Increased Gray Matter Density in Patients With Schizophrenia and Cannabis Use: a Voxel-based Morphometric Study Using DARTEL. Schizophr Res. 2012;138(2-3):183-7. PubMed PMID: 22475382.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. AU - Schnell,Thomas, AU - Kleiman,Alexandra, AU - Gouzoulis-Mayfrank,Euphrosyne, AU - Daumann,Jörg, AU - Becker,Benjamin, Y1 - 2012/04/03/ PY - 2011/12/31/received PY - 2012/03/03/revised PY - 2012/03/12/accepted PY - 2012/4/6/entrez PY - 2012/4/6/pubmed PY - 2012/10/25/medline SP - 183 EP - 7 JF - Schizophrenia research JO - Schizophr. Res. VL - 138 IS - 2-3 N2 - Alterations in gray matter density as well as cognitive impairments are commonly described in patients with schizophrenia (SCH patients). Both gray matter deficits and cognitive impairments have recently been discussed to represent vulnerability markers of schizophrenia. The counterintuitive finding of better cognitive performance in patients with schizophrenia and cannabis use (SCH+CAN patients) compared to cannabis naïve patients is discussed as a reflection of lower vulnerability for schizophrenia in at least one subgroup of SCH+CAN patients. We hypothesized that SCH+CAN patients would display fewer gray matter deficits compared to SCH patients reflecting their presumed lower vulnerability. We therefore compared gray matter density in 30 first episode SCH+CAN and 24 first episode SCH patients using a fast diffeomorphic registration algorithm (DARTEL) and voxel-based morphometry (VBM). We found less severe cognitive impairments and middle frontal gray matter deficits in the SCH+CAN patients. In the pooled sample gray matter density was positively associated with cognitive functioning. Results may support the hypothesis of a lower biological vulnerability in at least one subgroup of SCH+CAN patients. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/22475382/Increased_gray_matter_density_in_patients_with_schizophrenia_and_cannabis_use:_a_voxel_based_morphometric_study_using_DARTEL_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(12)00174-0 DB - PRIME DP - Unbound Medicine ER -