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Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL.
Schizophr Res 2012; 138(2-3):183-7SR

Abstract

Alterations in gray matter density as well as cognitive impairments are commonly described in patients with schizophrenia (SCH patients). Both gray matter deficits and cognitive impairments have recently been discussed to represent vulnerability markers of schizophrenia. The counterintuitive finding of better cognitive performance in patients with schizophrenia and cannabis use (SCH+CAN patients) compared to cannabis naïve patients is discussed as a reflection of lower vulnerability for schizophrenia in at least one subgroup of SCH+CAN patients. We hypothesized that SCH+CAN patients would display fewer gray matter deficits compared to SCH patients reflecting their presumed lower vulnerability. We therefore compared gray matter density in 30 first episode SCH+CAN and 24 first episode SCH patients using a fast diffeomorphic registration algorithm (DARTEL) and voxel-based morphometry (VBM). We found less severe cognitive impairments and middle frontal gray matter deficits in the SCH+CAN patients. In the pooled sample gray matter density was positively associated with cognitive functioning. Results may support the hypothesis of a lower biological vulnerability in at least one subgroup of SCH+CAN patients.

Authors+Show Affiliations

Medical School Hamburg, Am Kaiserkai 1, 20457 Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22475382

Citation

Schnell, Thomas, et al. "Increased Gray Matter Density in Patients With Schizophrenia and Cannabis Use: a Voxel-based Morphometric Study Using DARTEL." Schizophrenia Research, vol. 138, no. 2-3, 2012, pp. 183-7.
Schnell T, Kleiman A, Gouzoulis-Mayfrank E, et al. Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. Schizophr Res. 2012;138(2-3):183-7.
Schnell, T., Kleiman, A., Gouzoulis-Mayfrank, E., Daumann, J., & Becker, B. (2012). Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. Schizophrenia Research, 138(2-3), pp. 183-7. doi:10.1016/j.schres.2012.03.021.
Schnell T, et al. Increased Gray Matter Density in Patients With Schizophrenia and Cannabis Use: a Voxel-based Morphometric Study Using DARTEL. Schizophr Res. 2012;138(2-3):183-7. PubMed PMID: 22475382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased gray matter density in patients with schizophrenia and cannabis use: a voxel-based morphometric study using DARTEL. AU - Schnell,Thomas, AU - Kleiman,Alexandra, AU - Gouzoulis-Mayfrank,Euphrosyne, AU - Daumann,Jörg, AU - Becker,Benjamin, Y1 - 2012/04/03/ PY - 2011/12/31/received PY - 2012/03/03/revised PY - 2012/03/12/accepted PY - 2012/4/6/entrez PY - 2012/4/6/pubmed PY - 2012/10/25/medline SP - 183 EP - 7 JF - Schizophrenia research JO - Schizophr. Res. VL - 138 IS - 2-3 N2 - Alterations in gray matter density as well as cognitive impairments are commonly described in patients with schizophrenia (SCH patients). Both gray matter deficits and cognitive impairments have recently been discussed to represent vulnerability markers of schizophrenia. The counterintuitive finding of better cognitive performance in patients with schizophrenia and cannabis use (SCH+CAN patients) compared to cannabis naïve patients is discussed as a reflection of lower vulnerability for schizophrenia in at least one subgroup of SCH+CAN patients. We hypothesized that SCH+CAN patients would display fewer gray matter deficits compared to SCH patients reflecting their presumed lower vulnerability. We therefore compared gray matter density in 30 first episode SCH+CAN and 24 first episode SCH patients using a fast diffeomorphic registration algorithm (DARTEL) and voxel-based morphometry (VBM). We found less severe cognitive impairments and middle frontal gray matter deficits in the SCH+CAN patients. In the pooled sample gray matter density was positively associated with cognitive functioning. Results may support the hypothesis of a lower biological vulnerability in at least one subgroup of SCH+CAN patients. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/22475382/Increased_gray_matter_density_in_patients_with_schizophrenia_and_cannabis_use:_a_voxel_based_morphometric_study_using_DARTEL_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(12)00174-0 DB - PRIME DP - Unbound Medicine ER -