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[The clinical significance of MIBG myocardial scintigraphy in Parkinson disease].
Brain Nerve. 2012 Apr; 64(4):403-12.BN

Abstract

Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy can assess postganglionic presynaptic cardiac sympathetic nerve endings. Reduced cardiac MIBG uptake on MIBG myocardial scintigraphy has been reported in patients with Parkinson disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and familial PD linked to SNCA duplication. This imaging procedure is a sensitive diagnostic tool that might differentiate PD and DLB from other movement disorders from Alzheimer disease (AD). We recently reported cardiac sympathetic denervation in PD, DLB, PAF, and familial PD linked to SNCA duplication which accounts for the reduced cardiac MIBG uptake in these disorders. The patients with PD, DLB, PAF and familial PD linked to SNCA duplication have Lewy bodies in the nervous system, whereas patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration, AD, and parkin-associated PD do not. However, in patients with MSA or PSP, cardiac sympathetic denervation was associated with the presence of Lewy bodies in the nervous system. Therefore, cardiac sympathetic denervation is closely related to the presence of Lewy bodies in the wide range of neurodegenerative processes. Thus, we conclude that reduced cardiac MIBG uptake is a potential biomarker for the presence of Lewy bodies in the nervous system. We infer that MIBG myocardial scintigraphy is a noninvasive tool for detecting Lewy bodies during life.

Authors+Show Affiliations

Department of Neurology, Kanto Central Hospital, Setagaya-ku, Tokyo, Japan.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

jpn

PubMed ID

22481513

Citation

Orimo, Satoshi. "[The Clinical Significance of MIBG Myocardial Scintigraphy in Parkinson Disease]." Brain and Nerve = Shinkei Kenkyu No Shinpo, vol. 64, no. 4, 2012, pp. 403-12.
Orimo S. [The clinical significance of MIBG myocardial scintigraphy in Parkinson disease]. Brain Nerve. 2012;64(4):403-12.
Orimo, S. (2012). [The clinical significance of MIBG myocardial scintigraphy in Parkinson disease]. Brain and Nerve = Shinkei Kenkyu No Shinpo, 64(4), 403-12.
Orimo S. [The Clinical Significance of MIBG Myocardial Scintigraphy in Parkinson Disease]. Brain Nerve. 2012;64(4):403-12. PubMed PMID: 22481513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical significance of MIBG myocardial scintigraphy in Parkinson disease]. A1 - Orimo,Satoshi, PY - 2012/4/7/entrez PY - 2012/4/7/pubmed PY - 2012/6/22/medline SP - 403 EP - 12 JF - Brain and nerve = Shinkei kenkyu no shinpo JO - Brain Nerve VL - 64 IS - 4 N2 - Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy can assess postganglionic presynaptic cardiac sympathetic nerve endings. Reduced cardiac MIBG uptake on MIBG myocardial scintigraphy has been reported in patients with Parkinson disease (PD), dementia with Lewy bodies (DLB), pure autonomic failure (PAF), and familial PD linked to SNCA duplication. This imaging procedure is a sensitive diagnostic tool that might differentiate PD and DLB from other movement disorders from Alzheimer disease (AD). We recently reported cardiac sympathetic denervation in PD, DLB, PAF, and familial PD linked to SNCA duplication which accounts for the reduced cardiac MIBG uptake in these disorders. The patients with PD, DLB, PAF and familial PD linked to SNCA duplication have Lewy bodies in the nervous system, whereas patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration, AD, and parkin-associated PD do not. However, in patients with MSA or PSP, cardiac sympathetic denervation was associated with the presence of Lewy bodies in the nervous system. Therefore, cardiac sympathetic denervation is closely related to the presence of Lewy bodies in the wide range of neurodegenerative processes. Thus, we conclude that reduced cardiac MIBG uptake is a potential biomarker for the presence of Lewy bodies in the nervous system. We infer that MIBG myocardial scintigraphy is a noninvasive tool for detecting Lewy bodies during life. SN - 1881-6096 UR - https://www.unboundmedicine.com/medline/citation/22481513/[The_clinical_significance_of_MIBG_myocardial_scintigraphy_in_Parkinson_disease]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=1881-6096&rft.volume=64&rft.issue=4&rft.spage=403 DB - PRIME DP - Unbound Medicine ER -